BQ.1.1, XBB.1.5 & XBB.1 are the top circulating lineages in FL
22/n
XBB.1.5* still maintains a strong growth advantage over BQ.1*/BQ.1.1* lineages in USA
23/n
Special thanks to the specimen collection, sequencing and submitting labs, @CDCgov, @NIH/@NCBI, @GISAID Initiative, @PangoNetwork, Variant Trackers and Science enthusiasts!
24/n
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A total of 1886 sequences were submitted with specimen collection dates on or after 04/04/2024 (of which 373 (~19.8%) were collected via airport surveillance)
2/n
Predicted #ImmuneEscape vs ACE2 Binding Scores (Relative to BA.2)
Common theme among H5N1 clade 2.3.4.4b infected Cats:
- Present multiple symptoms almost immediately
- Neurologic, Respiratory, rapid decline leading to death
(or compassionate euthanasia)
- Pick PB2 mammalian adaptations
1/n
French Cat (2022)
Phylogenetic analysis linked the infection closely to virus circulating in the neighboring duck farm, with minor genetic differences.
Key mutations: PB2 E627K & NS: E26G
Again, rapid selection of mammalian adaptation mutation
2/n
Polish Cats (2023)
First widespread H5N1 clade 2.3.4.4b infection across a wide geographic area within a country
A total of 1509 sequences were submitted with specimen collection dates on or after 03/16/2024 (of which 69 (~4.6%) were collected via airport surveillance)
2/n
It's getting difficult to separate GBW airport vs baseline screening
#30DayTrends GBW uploaded 275 sequences
out of which 69 airport seqs & 206 baseline surveillance seqs
Here is a detailed account of their surveillance efforts