Thread by @RedefiningMECFS

A new publication by Simmaron!

“Potential molecular mechanisms of chronic fatigue in #LongCOVID and other viral diseases”
A hypothesis-driven review article demonstrates a diverse range of inflammatory & metabolic pathways responsible for fatigue of viral origin. 1/5

These 5 viruses (#HHV6, #Powassan, #EBV, #HIV, #SARS-CoV2) trigger unique immunological reactions, yet lead to similar inflammation + muscle fatigue. Examining these pathways can bring light to possible treatments for #mecfs #longcovid.

rdcu.be/c48cR 2/5

#HHV6
Immunosuppression, autoimmune reaction (IgM abs), microglial activation and production of #cytokines, Amyloid-beta, OPC immuration, demyelination 3/5

#Powassan
Proliferation of Th1 cells, IgM production, microglia-induced inflammation, demyelination in peripheral nerves

#EpsteinBarrVirus
EBV-specific CD8 + ve T cell-induced Muscle cell apoptosis, Reactive gliosis, and demyelination 4/6

#HIV
Mitochondrial permeabilization + depolarization of muscle cells, inflammatory T cell activation, microgliosis, #demyelination

#SARS-CoV2
Mitochondrial permeabilization + depolarization of muscle cells, inflammatory T cell activation, microgliosis, #demyelination 5/5