Discover and read the best of Twitter Threads about #cytokines

Most recents (13)

✨ We're delighted to present a new Special Issue on Human #Bcells!

Guest edited by @BemarkMats, @JoSpencerLab & @Thomas_J_Tull, this collection explores the complexity of #Bcell development & function

Explore the articles below 🧵 & read for free ➡️
As well as #Bcell subtypes in health & inflammatory diseases, this collection also examines aspects of B cell diversity depending on #immunoglobulin isotype & in a microanatomical context

Our guest editors introduce the series in this Editorial 👇 2/10…
Rebekah Velounias & @Thomas_J_Tull @KCLImmunoMicro kick off the series papers with a discussion of B cell subset classification & their changes in #inflammatory disease 3/10…
Read 10 tweets
A new publication by Simmaron!

“Potential molecular mechanisms of chronic fatigue in #LongCOVID and other viral diseases”
A hypothesis-driven review article demonstrates a diverse range of inflammatory & metabolic pathways responsible for fatigue of viral origin. 1/5 Image
These 5 viruses (#HHV6, #Powassan, #EBV, #HIV, #SARS-CoV2) trigger unique immunological reactions, yet lead to similar inflammation + muscle fatigue. Examining these pathways can bring light to possible treatments for #mecfs #longcovid. 2/5
Immunosuppression, autoimmune reaction (IgM abs), microglial activation and production of #cytokines, Amyloid-beta, OPC immuration, demyelination 3/5
Read 5 tweets
For anyone doing #flowcytometry, would you like to have a new protocol that reduces your #antibody costs by ~10-fold and also gives you higher quality data, with better signal-to-noise ratio?

Yes? Then read work by @olivertburton and @CarlyEWhyte. 1/6

…… Image
Bottom-line-up-front: stain overnight. Antibody staining is sensitive to both dilution and time, so a titration that gives crummy staining in 30' can actually give beautiful staining overnight. The best part is, that lower dilution gives less background, for better separation 2/6 Image
You can see this quite clearly with even tricky staining, like #Foxp3 and #cytokines. The overnight stain gives a stronger positive signal without increasing the background at all. Plus your cells are ready in the morning, when the cytometer is free, rather than 8pm at night! 3/6 Image
Read 6 tweets
"We evolved to be physically active. But most of us avoid physical activity."

The Active Grandparents Hypothesis

Daniel Lieberman, @Harvard

SFI Colloquium, streaming now:
"We evolved from #apes and apes are couch potatoes."

Daniel Lieberman, @Harvard

SFI Colloquium, streaming now:

#evolution #hominin #anthropology #physiology
"Your average hunter-gatherer walks from New York to LA every year."

Daniel Lieberman, @Harvard

SFI Colloquium, streaming now:
Read 24 tweets
Really chuffed to share our latest work from Sanjana Lab out in @nature today (…).

We tested >12,000 genes to find positive regulators of T cell proliferation to be used for next-gen #immunotherapies.

A thread...
(2/28) T cell therapies have shown the potential to cure patients from #cancer – but even in B cell cancers, relapses outnumber cures… One of the problems is limited T cell persistence. #celltherapy #CARTcell
(3/28) We wanted to find new genes (including genes never expressed in T cells) that could improve T cell persistence. Now, the question was: should we use #crispr activation or directly deliver target genes on a #lentivirus?
Read 30 tweets
01/ Vous voulez savoir :
- comment se protéger d’une #COVID sévère sans médicaments sur ordonnance ?
- pourquoi elle touche certaines personnes et pas d'autres ?
- ce qui cause les #EffetsSecondaires des #vaccins ?

#COVID_19 #covid19 #covid #coronavirus #vaccination

02/ Jean-Marc Sabatier (@SabatierJeanMa1), Directeur de Recherche au CNRS depuis 32 ans, PhD/HDR en Biochimie et Microbiologie, nous explique tout cela dans une vidéo ( dont je résume les 42 premières minutes dans ce #thread.
03/ Le virus #SARS-CoV-2 s’attaque au #SRA (le système rénine-angiotensine), un de nos systèmes de régulation les plus importants, responsable des fonctions autonomes rénales, pulmonaires, cardiovasculaires, de l’#immunité innée et du #microbiote intestinal.
Read 48 tweets
#Coronavirus #Covid19

#VitamineD | #FerLibre | #MicrobesDormants | #InflammationsChroniques | #Cytokines | #Hypercoagulation

📌 Hypothèse de la dérégulation du fer et des microbes dormants pour les maladies inflammatoires chroniques:
Les maladies les plus répandues actuellement sont de nature chronique et progressive, et s'accompagnent toutes d'une inflammation.
Ces maladies comprennent des maladies:
- neurodégénératives (par exemple, la maladie d'Alzheimer, la maladie de Parkinson)
- vasculaires (par exemple, l'athérosclérose, la pré-éclampsie, le diabète de type 2)
Read 33 tweets
Congratulations, Agnieszka @BartenschlagLab! We actually began working on this during the last pandemic threat (#Zikavirus) and the way through editor and reviewer offices was not exactly aided by the current pandemic. But now it’s finally out!…
Through TLR3, ZIKV induces proinflammatory #cytokines (IL-6, IL-10), which trigger STAT3 signaling, which in turn dampen #interferon responses. As #RIGI and #MDA5 sense ZIKV and induce IFN production, this antagonism eventually aids viral replication as we can show.
This is all so weirdly complex– a lot of work ahead to understand the details of innate immune regulation in virus infection. Ha, saying that– if you made it all the way to here in this thread, consider contributing to this special issue on exactly this topic ⬇️
Read 4 tweets
How does the immune system work? Will there be #COVID19 vaccines? @BioRender & I put together ‘immunology 101 tweetorial for non-immunologists’. @jerryguartist, @shizaoki, @JungHeeSciViz also made this accompanying video. Please share widely! (1/n)

The immune system protects the host from invading pathogens through 2 layers: the innate and adaptive immunity. Innate immunity acts within minutes to remove the pathogen. Adaptive immunity takes days/wks but is specific & long lived, and is the basis for #vaccines. (2/n)
Innate immunity starts by triggering sensors that detect unusual molecules or activities, known as pattern recognition. Once microbial patterns are detected by these sensors (#PRR), they trigger immediate alarm through secretion of #cytokines and #interferons. (3/n)
Read 13 tweets
THREAD from the new #bradykinin research (pre-print) from 🇳🇱:

"We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on #endothelial cells in the lungs."

#COVID19 #kinins…
➡️"the B1 receptor on endothelial cells is upregulated by proinflammatory #cytokines

➡️ Without #ACE2 acting as a guardian to inactivate the ligands of B1, the lung environment is prone for local vascular leakage leading to #angioedema"


#bradykinin #COVID19
➡️"... and might explain the typical #CTscans and the feeling of people that they drown.

➡️In some pt., this is followed by a clinical worsening of disease around day 9 due to the formation antibodies directed against the spike (S)-antigen of #SARSCoV2 that binds to #ACE2"
Read 12 tweets

#MECFS patients face disbelief that they are sick

Many #MECFS patients are told that they are simply tired, stressed, anxious, depressed, lazy or malingering

How can #pwME respond to such disbelief and lack of understanding??????

See thread below:
2. Below are 7 evidence-based scientifically supported findings that you can use to inform those who dont understand that #MECFS is a multi-organ, systemic and severely debilitating illness

From a lovely review by @HarvardAskDrK in @JAMA_current
3. #pwME have deficiencies in 3 organs important for the body's hormonal balances called the hypothalamic-pituitary-adrenal axis

Importantly, the deficiencies observed in #MECFS patients are quite different to that seen in #depression
Read 10 tweets
A new paper in @sciencemagazine from #Belkaid lab at #NIH described an #alternative differentiation #pathway for #commensal-specific T cells in presence of inflammation. Do the data presented support conclusions? Let's dive in.…
1. #Commnesal S. epidermidis–specific -#MIIINA:H2-M3+ CD8+ T cells ordinarily differentiate into Tc1 or Tc17 subsets. However, when co-exposed to chitin or sand fly (source of #inflammation), Tc17 subset also produce type II cytokines.
2. In such condition, type II #cytokines such as IL-5 or IL-13 are produced by CCR6+ Tc17 cells (out of which 30% are IL-17+). However, there is no overlap between IL-17+ and IL-5+/IL-13+ CD8+ T cells. So, the authors conclusion about "paradoxical phenotype" is unsubstantiated.
Read 10 tweets

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