1/
Is it ethical to interrupt a #RCT early because the treatment group is doing too well?
In my opinion NO
Here is a practical example
Is it ethical to interrupt a #RCT early because the treatment group is doing too well?
In my opinion NO
Here is a practical example
2/
Adding #pyridostigmine to standard care reduced mortality among patients hospitalized for severe #COVID19
in Mexico a small study of 94 patients per group performed in hospitalized, severe (on oxygen, but not intubated) #covid19 patients
molmed.biomedcentral.com/articles/10.11…
Adding #pyridostigmine to standard care reduced mortality among patients hospitalized for severe #COVID19
in Mexico a small study of 94 patients per group performed in hospitalized, severe (on oxygen, but not intubated) #covid19 patients
molmed.biomedcentral.com/articles/10.11…
3/
The magnitude of the effect apoparently is >glucorticoids >tocilizumab >paxlovid
And much much more than all the minor things which still excite covidiots (eg #ivermectin #hydroxychloroquine … )
The magnitude of the effect apoparently is >glucorticoids >tocilizumab >paxlovid
And much much more than all the minor things which still excite covidiots (eg #ivermectin #hydroxychloroquine … )
4/
Unfortunately this effect is most likely a bias of small studies
pubmed.ncbi.nlm.nih.gov/30394068/
What will happen now?
Nobody will use #pyridostigmine for #covid19 anywhere in the world
It was really a pity that this beautiful RCT was interrupted early!
Unfortunately this effect is most likely a bias of small studies
pubmed.ncbi.nlm.nih.gov/30394068/
What will happen now?
Nobody will use #pyridostigmine for #covid19 anywhere in the world
It was really a pity that this beautiful RCT was interrupted early!
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