1/
Is it ethical to interrupt a #RCT early because the treatment group is doing too well?

In my opinion NO

Here is a practical example
2/
Adding #pyridostigmine to standard care reduced mortality among patients hospitalized for severe #COVID19

in Mexico a small study of 94 patients per group performed in hospitalized, severe (on oxygen, but not intubated) #covid19 patients

molmed.biomedcentral.com/articles/10.11…
3/
The magnitude of the effect apoparently is >glucorticoids >tocilizumab >paxlovid

And much much more than all the minor things which still excite covidiots (eg #ivermectin #hydroxychloroquine … )
4/
Unfortunately this effect is most likely a bias of small studies
pubmed.ncbi.nlm.nih.gov/30394068/

What will happen now?
Nobody will use #pyridostigmine for #covid19 anywhere in the world

It was really a pity that this beautiful RCT was interrupted early!

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More from @giovannilandoni

Jan 1
in 1932 #oxygen was delivered subcutaneously!
with non-negligible success

#ARDS #ecmo
1/

physoc.onlinelibrary.wiley.com/doi/epdf/10.11…
In 1933 #oxygen wad delivered through the peritoneal cavity and stomach
with non-negligible success

#ARDS #ecmo
2/

physoc.onlinelibrary.wiley.com/doi/pdf/10.111…
In 1935 #oxygen was delivered intravenously
with non-negligible success

#ARDS #ecmo
3/

physoc.onlinelibrary.wiley.com/doi/pdf/10.111…
Read 5 tweets
Jun 12, 2021
We identified all sudden cardiac death occurring in Italian youngster (1-35y) and reported by media 2010-2015 under the leadership of @sozi81
pubmed.ncbi.nlm.nih.gov/33638776/
#Eriksen @IntensiveBot
1/ Image
Autopsy data were available in 100/132 (75.8%) cases: an extra cardiac cause was identified in 20 (20%). Among the 61 cases with a cardiac diagnosis, 21 (34%) had hypertrophic cardiomyopathy.
2/
Among the 19 (19%) victims without structural abnormalities, molecular autopsy identified pathogenic variants for channelopathies in 9 cases. Ten (10%) victims had no identifiable cause
3/
Read 7 tweets
Jul 27, 2020
1/
I want to thank all my colleagues for the wonderful #COVID19 research they published during these months: >200 PubMed-indexed articles from @SanRaffaeleMI @SRAnesthesiaICU @MyUniSR @azangrillo
I’ll summarize few of them in this thread.
2/
In February, before the start of #COVID19 in Europe, we suggested the use of helmet to deliver #CPAP #NIV in emergency departments. This can be a key issue to prevent future spread of respiratory pandemics in emergency departments.
thelancet.com/journals/lance…
3/
As soon as #COVID19 spread in Lombardy we helped other centers to manage their worst patients: 39 patients from other centers were admitted in our ICUs. The H was reshaped to cope with the new situation. The manusc cited 38 times in the first 4 months.
Read 19 tweets

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