Thread by @nick_krontiris

This one suggests that a small ventricle is a key factor that contributes to low midlife cardiorespiratory fitness in women, which may explain the predisposition of some women to functional impairment, exertional breathlessness, and heart failure with preserved ejection fraction.

- In this study, in healthy women free of overt cardiovascular disease and a mean age of 51 years, ventricular size was found associated with cardiorespiratory fitness and cardiac reserve, suggesting that small ventricle is a key factor that contributes to low midlife CRF:

A strong positive relationship between ventricular size and cardiorespiratory fitness was observed.

Diminished augmentation of cardiac function during exercise in women with small cardiac size was also observed.

- "Therefore, we submit that low CRF in this cohort could be partly explained by a “double hit” in which a smaller heart has a lesser capacity at rest and a lesser ability to augment function during exercise"

- These findings may suggest that this may be a possible mechanism explaining the predisposition of some women to functional impairment, exertional breathlessness, and heart failure with preserved ejection fraction later in life.

Too Little of a Good Thing: Strong Associations Between Cardiac Size and Fitness Among Women

doi.org/10.1016/j.jcmg…

#exercise #fitness #fit #FitFam #FitLife #FitnessAddict #Workout #TrainHard #GymLife #GymTime #muscle #strength #lift #GetStrong #cardio #hiit