Thread by @KetoCounselor

The blood-brain barrier (BBB) is a crucial defense mechanism for the brain, regulating the exchange of molecules between the bloodstream and the brain. When the BBB is disrupted, it can have severe consequences for brain health. (1/12)

Alzheimer's disease is one example of a condition that is exacerbated by BBB disruption. When the BBB is compromised, amyloid beta-peptide deposits can accumulate, leading to #inflammation and disruption of neuronal function. (2/12)

A disrupted BBB in #Alzheimers means astrocyte and microglia inflammation, disruption of synaptic transmission, and myelin destruction. (3/12)

#Parkinsons disease is another condition that is worsened by BBB disruption. When the BBB is compromised, α-synuclein aggregation can occur, leading to Lewy body disease and movement disorders. (4/12)

Ischemic #stroke is a neurological condition where BBB disruption can have severe consequences. It can cause and exacerbate cytotoxic edema, vasogenic edema, and hemorrhagic transformation, impairing neuronal function and leading to ischemic cerebral infarction. (5/12)

Amyotrophic lateral sclerosis #ALS is another condition where BBB disruption can cause significant harm. Neurotoxic substances and pathogens can enter the brain and trigger inflammatory responses, leading to muscle atrophy, paralysis, and respiratory failure. (6/12)

Huntington's disease is a condition where BBB disruption leads to the accumulation of fibrin deposits outside the cerebral vasculature. This can result in a range of physical, cognitive, psychiatric, and #metabolic abnormalities. (7/12)

Traumatic brain injury #TBI is another condition where #BBB disruption can have severe consequences. It can exacerbate brain edema, raise intracranial pressure, and lead to nerve damage, resulting in dyskinesia, cognitive disorder, disability, and death in severe cases. (8/12)

Do you know what is absolutely amazing for BBB health? Ketogenic diets. Don't believe me? Keep reading! I don't want you to think I just make this stuff up! (9/12) 🤷

A review published in Neuroscience & Biobehavioral Reviews suggested that ketone bodies may have protective effects on the BBB by reducing oxidative stress, inflammation, and excitotoxicity, all of which can contribute to BBB dysfunction: ncbi.nlm.nih.gov/pmc/articles/P… (10/12)

One of my fav books has a whole chapter devoted to the amazing effects of the ketogenic diet on BBB permeability. Thanks to @MasinoSusan for editing! (11/12)
academic.oup.com/book/40143/cha…

@MasinoSusan Your neurologist may not be helping you make these connections and helping you understand what this could mean for your recovery. So I share this because I want you to know all the ways you can feel better! (12/12) #neurology #ketones