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Dr Asad Khan FRCP FRACP 🇵🇸🇳🇿🇮🇳🇬🇧#pwLC Profile picture
@doctorasadkhan
Mar 24 • 7 tweets • 7 min read Twitter logo Read on Twitter
Sneak peek at our latest #LongCovid preprint about microclot detection using imaging flow cytometry

By Simone Turner, Jaco Laubscher, @resiapretorius & @dbkell

These are 1st results from the instrument YOU funded by donating to @givewithkernls

#TeamClots

1/n
Grey columns are using brightfield microscopy; black are using Thioflavin T

See the difference in size between #LongCovid & control microclots

There were statistically significant differences in mean size, number & other variables

More in the paper!

2/n Image
Why is this important?
Because flow cytometry is already accessible in clinical settings, unlike fluorescence microscopy which is mainly a research tool.

Big thanks to @gezmedinger @HarryLeeming @fearnley_k @Geraint6Jones @clarejdaly @loscharlos @ShaneyWright @j_b_kennedy 3/n
For helping raise the $161,000 needed to purchase the instrument!
Gratitude also to @VitalikButerin & Balvi for matching donations!
But most of all to the #chronicillness community for your support & generosity
#MECFS #Lyme #POTS #MCAS #EDS #Fibromyalgia #vaccineinjuries 4/n
Forgot to mention- I’m one of the authors as well…5/n
Huge thanks to @polybioRF @microbeminded2 for leading the fundraising effort!!!!
6/n
Link to flow cytometry preprint is live now! #TeamClots #TreatLongCovid

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More from @doctorasadkhan

Dr Asad Khan FRCP FRACP 🇵🇸🇳🇿🇮🇳🇬🇧#pwLC Profile picture
Mar 21
Our preprint about treatment of 91 #LongCovid patients with triple anticoagulant therapy is out! By Dr Jaco Laubscher, @resiapretorius @dbkell @JanPretorius98 & myself...
#ResearchLongCovid
#TreatLongCovid
#MECFS
#TeamClots
#MedTwitter
#MedEd 1/n
@resiapretorius @dbkell @JanPretorius98 Here is the study protocol
Symptoms by age 3/n
Read 14 tweets
Dr Asad Khan FRCP FRACP 🇵🇸🇳🇿🇮🇳🇬🇧#pwLC Profile picture
Feb 5
To those intent on psychologising #LongCovid & #MECFS because ‘there is no biomarker’- let me tell you something as a senior Dr. Many diseases don’t have biomarkers & diagnosis is clinical. Take asthma for example. Symptoms vary between patients. 1/n
Many patients have abnormal exhaled nitric oxide (FeNO) & histamine challenge tests- some don’t. Yet if the patient’s symptoms & signs fit with asthma, we have no hesitation in making the diagnosis. 2/n
There is the well-known example of multiple sclerosis. Many deemed it psychogenic because there was no lab or radiology test that was diagnostic. Until of course the MR scan was invented. 3/n
Read 8 tweets
Dr Asad Khan FRCP FRACP 🇵🇸🇳🇿🇮🇳🇬🇧#pwLC Profile picture
Nov 28, 2022
Treating hospital discharges for 14 days with half a dose of one anticoagulant does NOT mean that ‘anticoagulants are ineffective in #LongCovid’ (HEAL-COVID study) 1/n
-this is a different population to the vast majority of #LongCovid
-the role of the hyperactivated platelet has been totally disregarded
-treatment dose apixaban is 5mg bd, not 2.5mg
-even if the correct population & drugs were used, #LongCovid does not get better in 14 days 2/n
The ramifications of this could be catastrophic. It could shut the door on funding for properly designed anticoagulant trials. And millions will continue to endure agony. I cannot emphasise enough what a serious own-goal this is.
Read 5 tweets
Dr Asad Khan FRCP FRACP 🇵🇸🇳🇿🇮🇳🇬🇧#pwLC Profile picture
Oct 14, 2022
Latest #TeamClots preprint on clotting abnormalities in #LongCovid. We demonstrated that the average levels of 6 inflammatory procoagulatory molecules were significantly higher in the soluble fraction of blood in #LongCovid when compared to controls medrxiv.org/content/10.110… 1/n
These werealpha-2-antiplasmin (A2AP), serum amyloid A (SAA), platelet factor 4 (PF4), E-selectin, von Willebrand Factor (VWF) & platelet endothelial cell adhesion molecule-1 (PECAM-1). The mean A2AP level exceeded the upper limit of the lab reference range in #LongCovid 2/n
Considering that large quantities of these molecules have already been detected inside microclots using proteomics, the elevation in plasma/serum means that total levels of these inflammatory mediators are indeed alarming in #LongCovid 3/n
Read 8 tweets
Dr Asad Khan FRCP FRACP 🇵🇸🇳🇿🇮🇳🇬🇧#pwLC Profile picture
Sep 23, 2022
Now with English subtitles- #LongCovid documentary featuring myself, @BrockAnnaDr, @BeateJaegerMD, @C_Scheibenbogen amongst others. rumble.com/v1kzjhz-h.e.l.…
Also dives into #MECFS interviewing @pausedME
@slpglondon @GiacomoMingardo also make an appearance
Read 4 tweets
Dr Asad Khan FRCP FRACP 🇵🇸🇳🇿🇮🇳🇬🇧#pwLC Profile picture
Aug 7, 2022
A thread on my experience with @Vedicinals_9 for my #LongCovid. Please note that this is information & not advice. Also, I have paid for @Vedicinals_9 & have not been asked to promote the product by the vendor #LongCovid #MECFS #PoTS #MCAS 1/n
Background- I experienced significant benefit from HELP apheresis & anticoagulation between Sep & Dec 2021, to the point of being able to self-care & take short walks. Unfortunately omicron x 3 more or less undid those gains & I was barely managing bed to bathroom by May 2022 2/n
I was aware of others who had reliably reported great success with @Vedicinals_9 so decided to give it a go. My physician agreed. The vendor was extremely responsive to questions & gave specific instructions on dosing & administration (this is crucial) 3/n
Read 18 tweets

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