1/ 2023 Association for Research in Vision and Ophthalmology Annual Meeting. arvo.org/annual-meeting/. Accepted abstracts from Ophthalmic Biophysics Center about its Rose Bengal Photodynamic Antimicrobial Therapy (RB PDAT). #ARVO23 #ARVO2023. @BascomPalmerEye @UMiamiHealth. A… twitter.com/i/web/status/1…
2/ Abstract Number: 606 - B0243. Echeverri Tribin F et al. Inhibition of Multidrug-Resistant Pseudomonas aeruginosa with Rose Bengal Photodynamic Antimicrobial Therapy: In vitro. Conclusions: MDR Pseudomonas aeruginosa can be inhibited by rose bengal eppro02.ativ.me/web/page.php?p…twitter.com/i/web/status/1…
3/ Abstract Number: 609 - B0246. Krishna et al. In vitro Inhibition of Aspergillus and Fusarium Species with Erythrosin B, Eosin Y, and Rose Bengal Photodynamic Antimicrobial Therapy. Conclusions: EB, EY, and RB with light were effective against both F. eppro02.ativ.me/web/page.php?p…twitter.com/i/web/status/1…
4/ Abstract Number: 3294. Rocchetti et al. Action of Rose Bengal photoactivated by green light associated or not to Propamidine Isethionate and/or Polyhexamethyl Biguanide on Acanthamoeba trophozoites cells – in vitro study. Conclusions: This in vitro eppro02.ativ.me/web/page.php?p…twitter.com/i/web/status/1…
5/ Abstract Number: 4027 - B0344. Chen et al. Rose Bengal Penetration Depth with Iontophoresis in Human Cornea Tissue. Conclusions: Corneal penetration of RB disodium is significantly improved by utilizing iontophoresis. These findings support the eppro02.ativ.me/web/page.php?p…twitter.com/i/web/status/1…
6/ THREAD END.
7/ @threadreaderapp unroll

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More from @ProvectusBio

Mar 25
1/ $PVCT’s Modernized #SmallMolecule #RoseBengal: A #DrugSubstance, and #ActivePharmaceuticalIngredient for 21st Century #DrugDevelopment. A THREAD.
2/ “Everyone” seems to know or understand #RoseBengal, but do they (you) really?
3/ #RoseBengal is a small molecule (i.e., <1,000 Daltons*), but a “heavy” one at 973.67 Da or g/mol. It is heavy because of its four iodides, which comprise 52% of its molecular weight.
Read 12 tweets
Mar 22
1/ “Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy.” $PVCT thoughts: there’s no free lunch. A THREAD.
2/ 20Mar23: Endpoints: “BioNTech to pay $200M upfront in CTLA-4 antibody development, commercialization deal.” endpts.com/biontech-to-pa….
3/ The CTLA-4 asset BioNTech acquired is ONC-392. See here from #SITC21: jitc.bmj.com/content/jitc/9….
Read 17 tweets
Mar 8
$PVCT-related medical journal article: DePalo DK, Zager JS. Advances in Intralesional Therapy for Locoregionally Advanced and Metastatic Melanoma: Five Years of Progress. Cancers. 2023; 15(5):1404. doi.org/10.3390/cancer…. @MoffittNews @USFHealthMed. Intralesional agent PV-10… twitter.com/i/web/status/1… DePalo DK, Zager JS. Advances in Intralesional Therapy for L
Other $PVCT work by Dr. Zager (and Moffitt Cancer Center) as a principal investigator for us: PV-10 (#RoseBengalSodium) + #Keytruda (#pembrolizumab) for immune checkpoint blockade-naïve Stage III cutaneous melanoma © 2023, Provectus Biopharmaceuticals, Inc. https://www.prov
Other $PVCT work by Dr. Zager (and Moffitt Cancer Center) as a principal investigator for us: PV-10 (#RoseBengalSodium) + #Keytruda (#pembrolizumab) for immune checkpoint blockade-refractory advanced melanoma © 2023, Provectus Biopharmaceuticals, Inc. https://www.prov
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Mar 6
1/ $PVCT’s PV-10 (#RoseBengalSodium) Immuno-Oncology Cycle & PD-1-Combination Mechanism. A #THREAD. #InduceAndBoost.
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Read 18 tweets
Feb 17
1/ The impact of #Covid on $PVCT’s R&D, #DrugDiscovery, and clinical development of our #HalogenatedXanthene (#HX) medical science platform and #RoseBengalSodium (#RBS) investigational drug & drug formulation pipeline. A #THREAD.
2/ This $PVCT #thread will be an ongoing one for some time. Please check back to read it again (and again), and learn more about our medical scientific history and our lead molecule #RoseBengalSodium’s journey to becoming a multi-disease, broad-spectrum, therapeutic compound.
3/ #Covid has been a deeply painful experience, to say the least, for the U.S. and the world. It also marked a turning point in the advancement and expansion of our #HX medical science platform, as well as our lead molecule #RoseBengalSodium and the investigational drugs and drug… twitter.com/i/web/status/1…
Read 63 tweets
Jan 27
1/ A $PVCT THREAD: (3) Potential 2023 read outs of preclinical data from sponsored research programs (#SRAs) in different diseases. #research. #oncology #hematology #dermatology #InfectiousDiseases #ophthalmology #WoundHealing #TissueRegeneration. #rosebengal #rosebengalsodium.
2/ $PVCT 2023 Stockholder Letter (released January 9th). . #rosebengal #rosebengalsodium.
3/ In 2023, $PVCT expects research collaborators at different academic medical institutions to read out data from their preclinical research work under newly established and existing #SRAs. #research. #rosebengal #rosebengalsodium.
Read 60 tweets

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