✨ We're delighted to present a new Special Issue on Human #Bcells!

Guest edited by @BemarkMats, @JoSpencerLab & @Thomas_J_Tull, this collection explores the complexity of #Bcell development & function

Explore the articles below 🧵 & read for free ➡️bit.ly/40O6Onh
As well as #Bcell subtypes in health & inflammatory diseases, this collection also examines aspects of B cell diversity depending on #immunoglobulin isotype & in a microanatomical context

Our guest editors introduce the series in this Editorial 👇 2/10
Rebekah Velounias & @Thomas_J_Tull @KCLImmunoMicro kick off the series papers with a discussion of B cell subset classification & their changes in #inflammatory disease 3/10
Next, Gjertsson et al. @goteborgsuni provide a close-up on the expanding landscape of CD21–/low #Bcells in humans 4/10
Our attention then shifts to B cell #immunoglobulin isotypes, as @louisakjames @blizard_inst looks at how #immunity is regulated by human #antibody subclasses at the cellular level 5/10
From @JoSpencerLab, Lucia Montorsi & @JQ_Siu @KCLImmunoMicro examine the spatial structure of #lymphoid tissues & the localisation of B cell subsets including marginal zone B cells 6/10
Nina M de Gruijter, Bethany Jebson & @bcells_rosser @UCL_RheumAYA then explore the array of #cytokines secreted by #Bcell subsets & their roles in health & #autoimmune diseases 7/10
Kristine Oleinika @Kristine_PhD et al. @bcells_rosser @UCL_RheumAYA @RSUinfo review the alteration of #Bcell subset composition in cases of #obesity & the factors that drive this 8/10
Here, Bjarnarson & Brynjólfsson @Landspitali review the induction of long-lasting #ImmuneResponses & how the availability & retention of antigen is necessary for a long-lasting #antibody response, with focus on #SARSCoV2 #vaccine responses 9/10
Finally, Ola Grimsholm @MedUni_Wien looks at new discoveries on #CD27 human memory #Bcells in health & disease, describing how Ig sequencing can be used as a tool to decipher the evolutionary pathways of these cells 10/10

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