Discover and read the best of Twitter Threads about #autoimmune

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✨ We're delighted to present a new Special Issue on Human #Bcells!

Guest edited by @BemarkMats, @JoSpencerLab & @Thomas_J_Tull, this collection explores the complexity of #Bcell development & function

Explore the articles below 🧵 & read for free ➡️
As well as #Bcell subtypes in health & inflammatory diseases, this collection also examines aspects of B cell diversity depending on #immunoglobulin isotype & in a microanatomical context

Our guest editors introduce the series in this Editorial 👇 2/10…
Rebekah Velounias & @Thomas_J_Tull @KCLImmunoMicro kick off the series papers with a discussion of B cell subset classification & their changes in #inflammatory disease 3/10…
Read 10 tweets
In a Debate:

#Ayurveda scriptures don’t hv any MODERN MEDICINE TERM like #Psoriasis, #autoimmune diseases & u claim that u treat it??

#Ayurveda scriptures also don’t hv any term like MAN - tomorrow you’ll say how m I treating a man?
It’s ur problem that you think
that SCIENCE can be discussed only in ENGLISH language, but SCIENCE was actually discussed in #Sanskrit centuries ago.

Ok, then where is Psoriasis & it’s treatment discussed in #Ayurveda.

Under the topic KUSHTHA(कुष्ठ)

So u do the LEPROSY treatment 4 #psoriasis 😂
When did I say this?

U said na KUSHTHA, KUSHTHA means LEPROSY, that’s it…


Then what is KUSHTHA as per Ayurveda ??

As per Ayurveda, KUSHTHA means:
“कुष्णाति वपुः इति कुष्ठम!”

I don’t understand it, explain
Read 10 tweets
It's probably worth people learning about Epstein-Barr virus (human herpes virus 4).
It's a virus that pretty much everyone gets, the one that causes glandular fever, also known as #mononucleosis. 🧵
For many it's a simple cold, but for others it causes hepatitis, immunosuppression, autoimmune disease, and sometimes, several decades later, the neurodegenerative condition known as #MultipleSclerosis...…
It's worth talking about because it could easily be blown off as just a cold or a flu-like illness. Just like covid.
It infects white blood cells, lymphocytes, just like covid.
And it can cause a litany of acute and chronic medical problems, just like covid...
Read 12 tweets
Autonomic Nervous System (#ANS) Impairment
#Thread #midjourneyartwork #MedEd
#Dysautonomia is a condition that affects the ANS, which controls involuntary bodily functions, such as heart rate, blood pressure, digestion, and breathing. It can be caused by various factors, including #autoimmune diseases & viral infections like #COVID19.
The symptoms of #dysautonomia can vary depending on the underlying cause and can include lightheadedness, dizziness, syncope, rapid or irregular heartbeat, low blood pressure, gastrointestinal issues, difficulty breathing, and fatigue.
Read 13 tweets
Interstitial lung disease in rheumatic diseases
Dr. Vanessa Smith
#ILD #autoimmune 🫁🚨🩻
#25TenTopicsBCN #TenTopics
1⃣ Need for a multidisciplinary team
2⃣ Awareness in peers
Progressive pulmonary #fibrosis
#ILD #autoimmune 🫁🚨🩻
#25TenTopicsBCN #TenTopics
Risk factors in ILD
- #SSc-ILD
#ILD #autoimmune 🫁🚨🩻
#25TenTopicsBCN #TenTopics
Read 5 tweets
Just read the @NYMag piece about #longcovid and I've got a lot of critiques of it - as a journalist, as an editor, &, of course, as a person living with complex chronic illness. Briefly, here are some of the issues I see, ones I think turn up in a lot of magazine pieces:🧵
First, the piece conflates patients with #longCOVID and #POTS who might be helped by exercise rehab (done right--itself hard to find) with those who will be harmed by exercise. There are different groups. Important to make fine distinctions as a science writer.
I am a patient with #longcovid and #pots who has benefitted from exercise, but for the first months of #longcovid my dysautonomia was so bad that exercise led to days-long crashes. This is not complicated to grasp/understand/message--backed up by research; see @PutrinoLab etc.
Read 16 tweets
The lies 2020:

Don’t Panic, we go for #herdimmunity, #children can’t spread it and won’t be harmed

What was really
And use #schools as a tap for controlled spread. No transparency, no testing no mask

Lets spread the lie that mask simply don’t work

Here #polarisation starts driven by misinformation and intransparancy by your government. Everybody could see that the measures were nog in line with urgency.

What were they hiding? Why no #zerorisk #zerocovid with borders closed. It could be done

2020: wait we know this will
Lead to many many deaths but the #vaccin is almost here, working hard, we know the #SPIKE is a big thing, hold on #Hopium being built.

Meanwhile lets keep up the lie of children not important to monitor😢 we know from SARS they build less #antibodies lets presume they just not
Read 31 tweets
This week I spoke to @JamesTGallagher at @BBCRadio4 about what it is like to be #immunocompromised and #shielding from covid for nearly 1000 days.👇…

Here's a 🧵 about why I told my family's story. 1/15 @LUPUSUK @RAIRDA_org #evusheld #Forgotten500k
I am one of 500k people in the uk who is still #shielding nearly 3 years into the pandemic. We are all #immunocompromised due to #autoimmune diseases, transplants and blood cancers 2/15 @bloodcancer_uk @kidneycareuk @LUPUSUK @RAIRDA_org #Forgotten500k @evusheld4theuk Image
Like thousands of others, I am not only more vulnerable to severe illness from covid due to my illness #lupus, but I am completely unprotected despite vaccination. As a result I need alternative treatments like #evusheld 3/15 @DHSCgovuk @RobertJenrick @evusheld4theuk Image
Read 15 tweets
Interesting. I wish my brain worked, brainfog is thick atm.
#bipolar #EBV #autoimmune
Hypothesis: bipolar disorder is an Epstein–Barr virus‐driven chronic autoimmune disease – implications for immunotherapy…
The high anti‐EBV antibody titres in BD might reflect a high number of EBV‐infected cells. It is interesting to note that clozapine, an atypical antipsychotic drug used to treat BD, inhibits EBV reactivation.
If BD is an EBV‐induced chronic autoimmune disease, there are two ways to control EBV infection specifically and therefore treat BD: (1) treatment with antiviral drugs; and (2) improving immunity to EBV.
Read 6 tweets
Thread 🧵👇:
After so many years of work and as a post Epstein-Barr virus infection #MECFS sufferer it makes me really happy that they have put our article on the cover of the August issue of Pathogens journal 👉
Until recently nobody talked about post-viral syndromes (actually they should be called chronic infectious syndromes) and they left all of us patients isolated both at a health and social level. Unfortunately it took another virus like #SARSCoV2 to show us how viruses are ...(2/)
...capable of developing chronic diseases like #LongCovid . It is curious that for bacterial infections we use antibiotics but for viral infections we leave it to our immune system to manage to control it. This must change. (3/)
Read 15 tweets
A long thread 👇🏼:
I would like to share with you my latest review article. The Epstein-Barr virus (EBV) has long been known to be behind the development of autoimmune diseases, cancer and is even suspected to be behind the development of Chronic Fatigue Syndrome/… (1)
…Myalgic Encephalomyelitis and Long COVID. But it is still unclear what pathways it uses.

In this review I describe how the possession of certain ancestral HLA-II alleles (a system used by our immune system to recognize which proteins are foreign,… (2)
…such as pathogens, and which are not) makes the individual genetically weak to control EBV latent cells, thus developing different diseases. EBV infects B cells through a protein on its surface called gp42, which allows it to bind to HLA-II molecules on the B cell surface. (3)
Read 23 tweets
#Immunosuppressive therapy in virus-negative inflammatory CMP : 20-year follow-up of the #TIMIC trial

Immunosuppressive Tx of virus-negative inflammatory #CMP is associated to a persistent improvement of LV
function and better outcomes during long-term follow-up

#Immunosuppressive Tx promoted an improvement in cardiac function in 88% of the cases compared the placebo group

A persistent ⤴️ in the #LVEF is seen in long -term (up to 20 years) clinical outcomes of the whole cohort of 85 patients originally enrolled in the #TIMIC trial
Recurring virus-negative myocarditis responding to #immunosuppressive therapy

EKG showing LBBB (A) resolving after therapy (B)

(C and D) Echo apical view showing recovery of LV dysfunction from EF -28% ➡️ up to 51%

#HeartFailure #EchoFirst @ESC_Journals…
Read 6 tweets
Thread of anecdotal experiences July 2022
'100% masks damage children’s normal development. When I do 8 week checks the baby will NEVER smile before I take off my mask and smile at them.'
posted by
Read 84 tweets
THABETA protocol

To treatment #COVID vaccine #side_effect

This protocol is designed to detox from the #spike_protein amyloid after the #mRNA vaccine to avoid #long_Covid and to remove triggers for #autoimmune disease after vaccination.
1837 patients with different side effects post COVID mRNA vaccine or suffering from long Covid symptoms have and are using this protocol
Efficacy = 97%
Against: #Myocarditis, #pericarditis , #MS , #Billy's palsy , #insulin_resistance #vasculitis , and other autoimmune conditions
1. N-acetyle cysteine: 2000 mg daily
NAC works as antidote for amyloid spike protein and removes proteins produced from ORF3a embedded in cell surface.
Read 9 tweets
⚠️Potentially dangerous
new 🦠#COVID19 variants🧬
▪️The pandemic won't end until we prevent this phenomenon
❗️Get💉 vaxxed to shield & protect the immunocompromised… #bioinformatics #WomenInSTEM #openscience #snrtg #immunology #genomics #raredisease
. "NOBODY is safe from the virus until
we are ALL safe from the virus"
~Dr. Tedros Ghebreyesus (WHO Director General)
Viruses🦠do strange things when unchallenged for long periods of times in hosts.
Unfortunately mutating🧬is one of those things.
Read 8 tweets
1/As promised & after reading $NTLA latest Q1 2022 financial report here is my analysis regarding @intelliatx latest corporate status. I have focused only on the main issues that I found to be the most interesting & relevant. #CRISPR #GeneEditing #BioTech #FinTwit #Genomics👇
2/NTLA-2001 is the most advanced In-Vivo #CRISPR/#Cas9 #GeneEditing program in $NTLA portfolio & is aimed to treat Transthyretin Amyloidosis - (ATTR). NTLA-2001 could potentially halt & reverse the disease in a “one time” treatment by knocking out the TTR gene with a single dose
3/In February $NTLA has presented an updated clinical data from its Phase 1 study of NTLA-2001 which included 15 patients with ATTR amyloidosis. IMO NTLA-2001 readout looks promising & here is a summary that I wrote shortly after @intelliatx’s presentation of NTLA-2001👇
Read 14 tweets
#LongCovid recovery story is long but short notes here:
#POTS confirmed with heart rate variability test & started on Ivabradine.
#MCAS treated based on clinical symptoms with Desloratadine, Famotadine, Montelukast-Cetrizine
#autoimmune assays done - #rheumatoidarthritis
Started on Methotrexate after all vaccinations. GI motility treated with Prucalopride.
Lung perfusion abnormalities but no cause detected (#microclots in blood) - treated with budesonide + tiatropium inhalers, ipratropium nebuliser & supplemental oxygen. #NEISvoid
Weekly IV infusions with Saline at home. Pulmonary rehabilitation. Eyes checked - connective tissue degeneration- tear film corrected with refresh tears & gel, special glasses & convergence exercises given.
Read 7 tweets
1/ #COVID-19 et #diabete : une contamination #SARScov2 peut-elle être un élément déclencheur ?

Très long (vraiment très long) #thread 🧵 ⤵️
2/ La plupart des personnes qui vivent avec une maladie chronique sont conscientes d’être plus à risque en cas de contamination #COVID. Celles qui vivent avec un #diabete #DT1 #DT2 ou autre, savent aussi qu’une infection, quelle qu'elle soit, peut provoquer une certaine
3/ résistance à l’insuline qui augmente la glycémie, accroit les besoins en #insuline, et peut parfois engendrer une complication potentiellement fatale, le coma acidocétosique. C’est particulièrement vrai en cas de contamination par le #COVID19.
Read 32 tweets
1/🧵 I think Chris Rock wouldn't have made a joke about Jada's illness if more folks were educated about the high prevalence of autoimmune & other chronic disorders.

#chronicillness #Spoonies #autoimmune #Alopecia #women #health #ChronicPain #chronic #illness #SickNotWeak
2/ As a woman who lives with multiple immune-related disorders, when a comedian makes a joke about chronic illness, I feel unseen...not just for me, but for all my fellow #chronicfolks. Does Chris Rock have any idea what Jada goes through to live with alopecia? Probably not.
3/ As a country, we need to create more dialogue around chronic illness, and especially autoimmune diseases. They are so prevalent yet they are usually talked about in whispers....'Oh, she has Crohn's.' Cancer used to be spoken about in hushed words, too.
Read 5 tweets
Thrilled to share our work on fine-mapping of immune-mediated diseases (IMD) using regulatory quantitative trait loci (QTLs) finally out in @NatureGenet…

@SoranzoTeam @sangerinstitute @Cambridge_Uni
#immunediseases #autoimmune #GWAS #QTL
🧵 1/14
Here we extended the evaluation of regulatory QTLs generated as part of the @blueprint_eu project to systematically map molecular mechanisms and causal variants at 12 immune-mediated diseases with publicly-available summary statistics. 2/14
📢 The BLUEPRINT "phase 2" genotype data and regulatory QTL summary statistics are available in the @EGAarchive ( under accession codes EGAD00001005192, EGAD00001005199 and EGAD00001005200.
Read 14 tweets

Deaths WITH #Covid19 age 0-19 yrs as of Nov 12 2021:


Reported #vaccine adverse events age 12-17 yrs as of Nov 12 2021:


"Canada prepares for the largest childhood #vaccination campaign since polio" under "Emergency Use Authorization". There is no emergency.
Deaths WITH covid - vs. reported "Vaccine adverse events"

Deaths WITH #Covid19 age 20-29 yrs as of Nov 12 2021:


Reported #vaccine adverse events age 18-29 yrs as of Nov 12 2021:


[Keep in mind flu has vanished, Most jab injuries go unreported.]

Deaths WITH covid - vs. reported "Vaccine adverse events"

Deaths WITH #Covid19 age 30-39 yrs as of Nov 12 2021:


Reported #vaccine adverse events age 30-39 yrs as of Nov 12 2021:


[Keep in mind the pharmaceutical industry funds Health Canada / 90% or higher]
Read 11 tweets
What happens if we allow #SARS2 to become endemic? What’s going to happen to us & what’s going to happen to the virus?

If we allow it to become endemic—and some would argue that it is already endemic—this does not mean that it is going to attenuate, not whatsoever. 1/
It is not true that more transmissible versions of #SARS2 will be more benign. What we are seeing is more aggressive, more transmissible versions which are creating more severe illness. And the virus is still adapting to our physiology. It’s doing it at a fantastic rate 2/
What we’re going to see is that it will continue to work against our immune systems, meaning become more immune evasive. It’s going to become more chronic as an infection. 3/
Read 14 tweets

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