Discover and read the best of Twitter Threads about #antibody

Most recents (22)

Have you heard the story about 'The #epidemic that wasn't'? These bizarre events took place in 2007, is a hospital in New Hampshire. Some things might sound familiar, living through the strange times today. It started when 1 of the doctors, had bad cough that lasted for weeks.
A colleague, specialized in infectious disease wondered if it was the start of whooping cough epidemic. When other health workers got the same severe cough, the idea of an epidemic was taken serious. If true containment measures are urgent as it is dangerous to babies and weak
patients. For months everyone was convinced the #epidemic was happening. Almost 1000 initial tests were done and 142 were diagnosed positive. All were given antibiotics and a vaccine. Eight months later the staff was informed it was false alarm. Not a single case was confirmed
Read 8 tweets
1/ The next hot-button issue in #COVID19 debates: the relative importance of #antibodies versus T cells in #COVID_19 immune response.

(If you're thinking this should be an obscure, wonky, data-driven debate, I have one word for you: hydroxychloroquine.)
2/ Some background. Antibodies are not the only possible source of #COVID19 immunity.

Or as this interesting @NatGeo article puts it, "antibodies might not be telling the whole story when it comes to #Covid_19 immunity."

on.natgeo.com/2DpoH6V #COVID
3/ Dr. Soo Aleman of Sweden tested patients who previously tested positive for #COVID19, as well as their close contacts. She found that hospitalized patients had strong antibody and T cell responses to #COVID_19 -- no surprise there.

#COVID #coronavirus
Read 18 tweets
Lots of talk about “skipping the phase III” trials of #COVID19 #vaccines and going straight to widespread vaccination.

Here’s a not-so-brief thread on why that’s a terrible idea.
1/
Ethical considerations aside, there are several reasons we *need* phase 3 trials as part of a developing COVID vaccines:
* Prove Efficacy
* Ensure Safety
* Conserve Limited resources
* Preserve Public confidence
2/
Efficacy
Despite efforts to develop vaccines against other coronaviruses (SARS, MERS) we haven’t yet succeeded

Against SARS-CoV2 we are trying a myriad of strategies: mRNA, recombinant, viral vectors, inactivated, etc. We hope one will succeed, but we don’t yet know which one
3/ Table of vaccine approaches...
Read 15 tweets
🤔#CostaRica & #China| From an expat|

"Health minister & president are all China 🇨🇳bought, look @ all the trade agreements with China.... China even has plastic boat factories just outside central America's under/over international waters

USA looking to move China out...

1/
#NEWS ..@SecPompeo discusses U.S.-Costa Rica relations in call with Foreign Minister #RodolfoSolanoQuirós

In a phone call, the duo “discussed the state of bilateral relations & analyzed prospects for strategic cooperation between #CostaRica & the US."

ticotimes.net/2020/07/28/mik…
...@SecPompeo again warned Costa Rica about “the People’s Republic of China’s empty promises to Central America,” the State Department’s summary of the phone call describes.

state.gov/secretary-pomp…
Read 5 tweets
(01/31) The late film critic @ebertchicago was not a huge fan of @rolandemmerich’s “Independence Day”. His review of the larger-than-life, schmaltzy blockbuster noted that it was little other than “silly summer fun”, which was reluctant to “slow down for the small details”.
(02/31) ‘Not slowing down’ is very much part of the modus operandi of blogger, hat model and occasional-#PrimeMinister Dominic Cummings. Particularly when maximising the fuel efficiency of the vehicle transporting his symptomatic family to medical facilities in Northern England.
(03/31) Cummings favours haste, brevity and a broad-brush approach over ‘the small details’. This is perhaps best demonstrated by his relentless promotion of catchy-yet-meaningless slogans, such as #StayAlert, #GetBrexitDone and #ConsiderTheMatterClosed.
Read 32 tweets
Been hearing some #COVIDmyths lately.
Here are facts about #COVID #antibodytesting from @CDCgov:

-Don’t use antibody tests to determine a person’s immune status until evidence confirms that antibodies provide protection;how much antibody is protective;&how long protection lasts
Antibody tests can support clinical assessment of COVID illness for people tested 9 to 14 days after illness onset, in addition to recommended virus detection methods such as PCR. This maximizes sensitivity. 2/
Antibody testing can help establish a clinical picture when patients have late complications of COVID-19 illness, such as multisystem inflammatory syndrome in children.3/
Read 8 tweets
Daily Bookmarks to GAVNet 6/18/2020-2

greeneracresvaluenetwork.wordpress.com/2020/06/18/dai…

Decision-Making in a Time of Crisis – O’Reilly

oreilly.com/radar/decision…

#DecisionMaking #crisis
Impacts of multiple stressors on freshwater biota across spatial scales and ecosystems | Nature Ecology & Evolution

nature.com/articles/s4155…

#impacts #scales #ecology #freshwater #ecosystems
Responsible Investment needs a bigger toolbox - Preventable Surprises

preventablesurprises.com/publications/b…

#investment #toolbox
Read 9 tweets
How can GPs help ensure #covid19 #antibody tests are used wisely? 100,000 (or is it 200,000?) tests a day is only useful if we get the right test, for the right patient and the right time. Thread 👇
GPs have been told to offer antibody testing to anyone having their blood taken who wants to know whether they have been infected with covid-19, even if there is ‘not a specific clinical indication’ pulsetoday.co.uk/news/gps-to-pr…
This could cause harm:
Accuracy of these tests needs further evaluation
Won’t change anything for most patients bbc.co.uk/news/health-52…
False positive results could reduce compliance with social distancing in those who assume they are immune
Wasted NHS resource
Wasted GP time
Read 9 tweets
1/30 In two forthcoming pieces, I examine #Japan's response to the #COVID19 #coronavirus #pandemic. I'll summarize the main non-theoretical points here (long thread alert!).
2/30 #Japan’s figures have always looked good compared to many other countries, which initially led to suspicion that the ‘real’ numbers of #COVID19 #coronavirus infections & death were being played down.
3/30 #Tokyo Metropolitan Government at least has now released full #COVID19 figures, including general death rates, seeming to put this argument to rest (but these figures are also now being challenged). japantimes.co.jp/news/2020/05/0…
Read 31 tweets
Coronavirus Showed That America Wasn't Up to the Task - The Atlantic

theatlantic.com/ideas/archive/…
#America
Antibody testing will enhance the power and accuracy of COVID-19-prevention trials | Nature Medicine

nature.com/articles/s4159…
#testing #accuracy #trials #serological #antibody
Read 8 tweets
Daily Bookmarks to GAVNet 5/14/2020

Machine learning platform generates novel COVID-19 antibody sequences for experimental testing

phys.org/news/2020-05-m…
#MachineLearning #antibody
The Gaslighting Has Begun. Resist.

link.medium.com/yaNYXmQqd6
#power #scale #pandemic
Choices for the “New Normal” | Health Disparities | JAMA | JAMA Network

jamanetwork.com/journals/jama/…
#health #coronavirus
Read 8 tweets
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..." ImageImageImage
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964 ImageImageImageImage
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily. ImageImageImageImage
Read 68 tweets
📰🔊This is our analysis of the #COVID19 #testing strategy in #Tunisia🇹🇳, given the potential technical and contextual limitations, and future challenges.

medium.com/@OpenNiqash/co…

Happy to contribute to @OpenNiqash with @Jaber_Bel, @drziedbouslama & @droussamazekri!
Real-time RT-PCR (@WHO gold standard) is complex and requires technical equipment and skilled human resources. Deploying a military mobile lab for temporary missions in the south is a good step, but still, testing capacity remains limited: only 24,406 tests performed as of 02/05.
Antigen and antibody rapid tests provide a less costly and faster delivery of results compared to RT-PCR. However, before these tests can be used, it must be acknowledged that they serve different roles and thus need to be used in different scenarios.
Read 9 tweets
ICYMI back on Feb. 7, 2020, I published: "A Harvester of Sorrow – First Wave of the SARS 2.0 Novel Coronavirus" / #COVID19 #1918Pandemic #Pandemic #Coronavirus #SARS traderstef.wordpress.com/2020/02/12/a-h… Image
San Francisco had the 1918 flu under control. And then it lifted the restrictions #COVID19 #1918Pandemic #Pandemic #Coronavirus #SARS nbcnews.com/politics/polit…
#COVID19 #1918Pandemic #Pandemic #Coronavirus #2ndWave no kidding, use summer as a time to prep just in case, no matter what anyone says, bc a virus is much smarter than any of you...
Read 318 tweets
Some have suggested that detection of #SARSCoV2 antibodies could be a basis for an “immunity passport” / “risk-free certificate” that will enable individuals to return to work. Currently, there is no evidence those who have recovered from #COVID19 are protected from re-infection.
Immunity to a pathogen through natural infection is a multi-step process that usually takes place over 1-2 weeks. The body responds to a viral infection immediately with a non-specific innate response: macrophages, neutrophils, dendritic cells slow the progress of the virus.
This non-specific response is followed by an adaptive response i.e. body makes #antibodies that specifically bind to the #virus. These #antibodies are proteins called #immunoglobulins. The body also makes T-cells that recognize & eliminate other cells infected with the virus.
Read 8 tweets
WARNING: As an ER doc in a rural hospital, I’m seeing the number of #COVID19 cases here *rise* as we start to plateau in NYC, Detroit, etc. Though @realdonaldtrump anticipates fewer new cases in so-called hot spots, I’m more concerned than ever. Here’s why: (1/11)
Rural hospitals run in a resource-limited environment on a daily basis. While we have most of the equipment we need, what we lack most is personnel. We frequently use traveling RNs to fill our needs, and many doctors travel from at least an hour away. (2/11)
At night we have one doctor, often me, in the whole hospital & one respiratory therapist. Normally, we manage just fine with the occasional night that feels like it will never end due to volume and acuity. But a surge in #COVID19 cases could reach crisis mode very quickly. (3/11)
Read 11 tweets
🚨 #Coronavirus Thread Part 3 🚨

Dr. Anthony Fauci announced that "antibody test is coming in a week or so". What does #antibody mean?

#Antibodies are proteins in the immune system that are developed after someone gets infected. It is the antibodies that make someone.../1
...immune against getting reinfected. In other words, what doesn't kill you makes you stronger.

It means two things;
1. You were previously infected.
2. You are likely to be protected against the #coronavirus at least for a while. Again, this is a paradox - a herd immunity.../2
sounds lovely and may dampen the 2nd wave of infection in the population but if the virus mutates (change in genetics), then it means a RESET and the entire population is once again at the mercy of the virus.

Why is antibody testing so vital? Why are governments.../3
Read 11 tweets
#Antibody response usually protects against infection/re-infection but #Tcells could protect against clinical signs of disease. #COVID19
The paper from #1990 analyzed the antibody response and clinical symptoms of the common cold #coronavirus #229E. Neutralizing antibody titers declined within 1 year after 1st challenge, and 70% from the "immunized" cohort got re-infected but none showed clinical symptoms.
This most likely explanation is that clinical symptoms were controlled by virus-specific T cells. There is an assumption here that a protective level of antibody would have prevented re-infection in the first plays
Read 11 tweets
👏🏼AWESOME👏🏼

NY health officials will collect “convalescent” plasma (liquid part of blood) from recovered #COVID19 patients & inject the #antibody-rich plasma into sick #coronavirus patients.

This approach was used during the 1918 Spanish Flu #pandemic.

nbcnews.com/health/health-…
Although convalescent plasma is “old school,” it has a good chance of success.

Convalescent plasma decreased the severity of symptoms & shortened hospital stays for #SARS, and preliminary reports from #China suggests it also works for #coronavirus.😃
#COVID19 convalescent plasma first will be given to critically ill #coronavirus patients. Once proven safe & effective (good chance!), it will likely work best if given BEFORE patients get critically ill. It might also be effective in protecting front-line health care workers.🤗
Read 3 tweets
@ntvde @NDR @c_drosten

Gutes Podcast über Herdenimmunität gg #Corona

Jedoch welches Tool würde helfen das von allen Virologen angestrebte Ziel der Grundimmunisierung am schnellsten zu erreichen?

Ein Shutdown evtl von 1 Jahr werden wir schwer meistern.
n-tv.de/mediathek/audi…
Food-for-Thought zu diesem Thema
...sorry etwas lang 😓 💦 (wird via @threadreaderapp zusammen'gerollt')

➡️ *SIND #ANTIBODY TESTS SINNVOLL?*

🔹Prof. Drosten @c_drosten hat im NDR Info, im sehr interessanten #coronavirus Update, kurz auch das Immunisierungsthema angeschnitten.
🔹Bei denjenigen, die eine Infektion überstanden haben wird der Virus sich nicht mehr replizieren können. Eine Ansteckung und Weitergabe ist dann nicht mehr möglich.
Read 11 tweets
THREAD: ANTIBODY GAME CHANGER TESTS AND DIAGNOSTIC REALITY. Most people don’t understand infectious disease and how ‘tests’ work. Like many things in science they’re not simply black and white things. This thread will explain in simple terms the value of #covid19 tests.
Infectious disease like #COVID19 has four phases: exposure, incubation, disease, resolution. Exposure is when you catch it. With COVID19, it involves coughs, droplets, aerosols and infected surfaces. Incubation is when the virus quietly minds its own business. No symptoms...
... and nothing to detect. Then the virus bursts the banks and floods you with new copies of itself- as many as the stars in the sky. From this point you can start detecting the virus. The most effective way is to look for its genome - a method known as PCR. PCR is best class...
Read 29 tweets
I’ve shifted everything to @Windows 10, the Subsystem for Linux #WSL, @WLinuxApp, a lightweight #zsh package manager #Antibody, and @code via a local X server. Windows stuff syncs via #OneDrive. #Linux stuff syncs via a #dotfiles repo.
I’ve been using WSL off-and-on since it came out, and the pace of improvement is really remarkable. The Windows dev team is seriously hustling to make their platform a good foundation for modern open-source development.
One think I really like is the ease of blowing away and rebuilding the entire Linux side of things. It really pairs well with the dotfiles movement to incrementally improve my use tool chain. I’ve automated the build of my stack so I can rebuild over lunch break.
Read 6 tweets

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