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Our latest paper describing #universal #CoV vaccine that can protect against #MERSCoV and #SARSCoV is now out in #preprint @YaleMed
Short thread 👇🏼
“Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice” biorxiv.org/content/10.110…
Short thread 👇🏼
“Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice” biorxiv.org/content/10.110…
We were interested in developing vaccination strategies against highly pathogenic human #coronaviruses with epidemic potential. Our previous studies, and those of others, defined the #RBD as a major target of neutralizing antibodies.
We therefore looked to #ferritin nanoparticles as a scaffold to display genetically divergent RBDs from both Group 2c merbecoviruses (#MERSCoV) and Group 2b sarbecoviruses (#SARSCoV , #SARSlike viruses, and #SARSCoV2). Our vaccines elicited broad binding antibodies in mice.
In addition, our #trivalent #nanoparticle vaccine also elicited high levels of neutralizing antibodies against #SARSCoV , #SARSCoV2 variants, and #MERSCoV using live viruses. Our vaccine also protected in lethal #MERSCoV and #SARSCoV mouse models.
We hope this type of next-generation universal vaccine will be useful in preventing or slowing down future CoV outbreaks. Great collaboration with @aschaefe29 @TheDHVI @Baric_Lab and @YaleIBIO
In short, we demonstrate proof-of-concept for a single pan-betacoronavirus vaccine to protect against three highly pathogenic human coronaviruses spanning two betacoronavirus subgenera.
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