Discover and read the best of Twitter Threads about #RBD

Most recents (9)

Our latest paper describing #universal #CoV vaccine that can protect against #MERSCoV and #SARSCoV is now out⁩ in #preprint@YaleMed⁩ ⁦

Short thread 👇🏼

“Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice”…
We were interested in developing vaccination strategies against highly pathogenic human #coronaviruses with epidemic potential. Our previous studies, and those of others, defined the #RBD as a major target of neutralizing antibodies.
We therefore looked to #ferritin nanoparticles as a scaffold to display genetically divergent RBDs from both Group 2c merbecoviruses (#MERSCoV) and Group 2b sarbecoviruses (#SARSCoV , #SARSlike viruses, and #SARSCoV2). Our vaccines elicited broad binding antibodies in mice.
Read 6 tweets
REM Sleep Behavior Disorder (RBD): what Miguel de Cervantes and Cinderella taught us. 😴😴💤🧠🧠👸✍️

A brief tweetorial.

#Neuro #NeuroTwitter #EndNeurophobia #Teaching #NeuroEducation #Sleep #RBD

The following thread has the objective to describe (in a general way) the main features of RBD, for more details, feel free to check the sources that I will add at the end of the tweetorial.

🥇What is REM sleep?
Sleep is divided in 4 phases, each of them is repeated during the 🌕in a cycle.

N1: vertex waves
N2: sleep spindles, k complexes
N3: slow-wave-sleep (restorative phase)
REM: rapid horizontal eye movement occurs, we dream and there is no muscle tone

Read 22 tweets
#Omicron features 50 mutations, with 15 mutations in the #RBD of the spike protein, which binds to the human #ACE2 for viral entry. However, it is not completely understood how these mutations alter the interaction and binding strength between the Omicron RBD and ACE2 1/
A new study by adopting a combined steered molecular dynamics (SMD) simulation and experimental microscale thermophoresis (MST) approach tried to quantify the interaction between Omicron RBD & ACE2. 2/
And what did they find?

Omicron brings an enhanced RBD-ACE2 interface through N501Y, Q493K/R, & T478K mutations; the changes further lead to unique interaction patterns, reminiscing the features of previously dominated variants, Alpha (N501Y) & Delta (L452R and T478K). 3/
Read 5 tweets
La #variante"Nu" B.1.1.529: segue un thread con le poche info che abbiamo. Ma non c'è da andare nel panico, ve lo spiego. Iniziamo. 1/21
Le autorità sudafricane sono allarmate per la rapida diffusione di una nuova #variante che in tre settimane è passata dall'1 al 30% di casi, soppiantando la #Delta (attualmente predominante nel mondo). Vediamo di cosa si tratta. 2/21
Si tratta di una variante di #SARSCoV2 emersa per la prima volta l’11 novembre 2021 a seguito di tre rilevamenti in #Botswana. 3/21
Read 21 tweets
01/ Vous voulez savoir :
- comment se protéger d’une #COVID sévère sans médicaments sur ordonnance ?
- pourquoi elle touche certaines personnes et pas d'autres ?
- ce qui cause les #EffetsSecondaires des #vaccins ?

#COVID_19 #covid19 #covid #coronavirus #vaccination

02/ Jean-Marc Sabatier (@SabatierJeanMa1), Directeur de Recherche au CNRS depuis 32 ans, PhD/HDR en Biochimie et Microbiologie, nous explique tout cela dans une vidéo ( dont je résume les 42 premières minutes dans ce #thread.
03/ Le virus #SARS-CoV-2 s’attaque au #SRA (le système rénine-angiotensine), un de nos systèmes de régulation les plus importants, responsable des fonctions autonomes rénales, pulmonaires, cardiovasculaires, de l’#immunité innée et du #microbiote intestinal.
Read 48 tweets
#Spike protein’ is the major target of #NAbs in infected/vaccinated people. The prefusion conformation of the Spike represents the most relevant target because Abs can successfully interfere w/ infection only if they prevent binding to target cells or prevent fusion itself 1/
Various approaches are adopted to express ‘#Spike’ protein in vivo, such as nucleic acid structures & virus vectors. Alternatively, other vaccine platforms like recombinant protein particles & inactivated vaccines can directly deliver this protein 2/
Most structural studies of the wild-type spike protein exhibited one #RBD in the 'open' conformation. By contrast, 2 or 3 RBDs were observed in the open conformation in the more infective #D614G mutant--the RBD #conformation plays a vital role in the infectivity of SARSCoV2 3/
Read 16 tweets
As a team of scientists from @scrippsresearch @karolinskainst @UniBonn @UniklinikBonn @IIIBonn @uni_tue @Illinois_Alma, we identified four potent neutralizing camelid nanobodies ...
Solved the #Xray structure of all four #nanobodies in complex with #SARSCoV2 spike #RBD @wchnihcholas and Ian Wilson ...
Used #CryoEM to determine that VHH E stabilizes the 3-up conformation of trimeric #SARSCoV2 spike @BMartinHallberg ...
Read 10 tweets

"We must move on from Neoliberalism in the post-COVID era. The 'Great Reset' offers an opportunity to re-evaluate sacred cows, defining the pre-pandemic era: the coming #Industry40 and the digitization of countless economic activities."…

"The #COVID19 crisis is going to accelerate a number of changes and transformations in human society. Notably, the pandemic is expected to significantly accelerate the Fourth Industrial Revolution."…
Read 26 tweets
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..." ImageImageImage
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964 ImageImageImageImage
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily. ImageImageImageImage
Read 68 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!