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WesElyMD Profile picture
@WesElyMD
May 30 • 3 tweets • 2 min read Twitter logo Read on Twitter
1/🧵 Long COVID’s “Disability Roulette”

🔺No longer a mass Death event…
🔺COVID-19 is an ongoing mass #Disability event
🔺You & I might get #LongCOVID
🔺But society is yawning

This thread unpacks science, policy & hope.

No Paywall Boston Globe link:
bit.ly/3OGfSb1 Image
Friends, this was my second attempt to send a full 20 tweet thread 🧵 uploading here (links, PDF images, etc etc -

but it’s stuck in twitter world.

I apologize for the glitch here. Oy!
See full thread here:

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More from @WesElyMD

WesElyMD Profile picture
May 31
Living w Disability

🔹I don’t know what you’re going through
🔹Is every day a struggle?
🔹Greg suffers #DownSyndrome, Alz Dz, Depression, Catatonia
🔹 Yet today he said, “Sunday’s donut day, but let’s have ‘chockle’ anyway & I’ll be ok.”

Be inspired‼️

(pic w perm)
#Recovery Image
#DownSyndrome #NothingDownAboutIt #UpSyndrome #MoreAlikeThanDifferent #DifferentNotLess #TheLuckyFew #ExtraChromosomeExtraCute #DownSyndromeLove #AdvocateLikeAMother #AdvocateLikeAFather #FindYourTribe #Tribe321 #DownSyndromeAwareness #Trisomy21 #T21 #SeeTheAbili
#ShoutTheirWorth #DontLimitMe #DownRightPerfect #LoveDoesntCountChromosomes #WouldntChangeAThing #DesignerGenes #LifeIsBetterWithYou #HomieWithAnExtraChromie #ChromosomallyEnhanced #NotSpecialNeedsJustHumanNeeds #Inclusion
Read 4 tweets
WesElyMD Profile picture
May 30
2/ The heartbreak we see has scientists working to discover answers💔

Drs. @VirusesImmunity & @PutrinoLab explore hypotheses

📍viral persistence
📍vital reactivation
📍autoimmunity
📍inflammation

Testing antivirals, immune modulators, blood thinners. bit.ly/45E1F4v Image
3/ Data from 223 unvaxxed Mild/Mod COVID survivors

✔️ Show abnormal MRI 🧠 white matter inflammation at 9 mo vs matched controls
✔️Prolonged cellular changes occur & we don’t yet know the significance
✔️Clinical outcomes vary strikingly across studies

bit.ly/43f0vL2 ImageImage
4/ Brain inflammation in other types of #Dementia…

🔸Is often present YEARS before memory & executive dysfunction deficits appear
🔸Don’t be complacent or assume #LongCOVID is safe for peoples’ brains
🔸It’s precarious!
🔸 I covered this haunting brain science in 🧵👇
Read 19 tweets
WesElyMD Profile picture
May 30
1/🧵 Long COVID’s “Disability Roulette”

🔺No longer a mass Death event…
🔺COVID-19 is an ongoing mass #Disability event
🔺You & I might get #LongCOVID
🔺But society is yawning

This thread unpacks science, policy & hope.

No Paywall Boston Globe link:
bit.ly/3OGfSb1 Image
Friends, I have an entire 20 tweet thread 🧵 uploading here (links, PDF images, etc etc -

but it’s stuck in twitter world.

I apologize for the glitch here. Oy!
2/ The heartbreak we see has scientists working to discover answers💔

Drs. @VirusesImmunity & @PutrinoLab explore hypotheses

📍viral persistence
📍vital reactivation
📍autoimmunity
📍inflammation

Testing antivirals, immune modulators, blood thinners. bit.ly/45E1F4v Image
Read 12 tweets
WesElyMD Profile picture
Feb 16
1/🧵The Haunting Brain Science of Long COVID
 
📍Here I use science to raise awareness of a growing public health nightmare hiding in plain sight
📍Matt & Barbara tell their stories
📍20 relevant medical articles
📍See 🧵unpacking science in Tweet #2
 
bit.ly/3ItiANv
2/🧵👇Here’s the science I included in the above @statnews piece

…one medical article after another, with take home messages about neuro #LongCOVID you can digest to keep yourself safe, find hope & teach other people what we’ve learned…
3/ Matt Fitzgerald’s story shakes me - a young engineer now disabled by #LongCOVID
 
“I feel like I’m underwater. When you talk to me, I can hear you, but my 🧠 doesn’t understand words. I can’t comprehend what you’re saying. I have no intellectual capacity to digest data.”
Read 8 tweets
WesElyMD Profile picture
Feb 6
1/🧵Your brain “on COVID”🧠
 
Let’s integrate >20 studies on #LongCOVID neuropathology
 
My 24 y/o patient explained: “I don’t have a future because I can’t think anymore.”
 
Let’s talk:
Autopsy Studies
Viral persistence
Brain Size & Disability
Recovery & Hope

H/T pic 👁️ tw 13 Image
2/ Autopsy Data 🧠

Despite initial improvement from COVID, these (N=27) pts got progressively sicker & died

From their autopsies, the authors found “SARS-Cov-2 infection persisted significantly longer than suggested by standard PCR-negative tests.”

bit.ly/3JrcX3l ImageImage
3/ Brain donation from 1st wave COVID patients (N=9) shows widespread endothelial activation, microclots & platelet aggregation supporting COVID as a vascular disease that yields real brain pathology.

IMAGE👇shows microglial nodules & neuronal injury

bit.ly/3kVCW8M ImageImageImage
Read 29 tweets
WesElyMD Profile picture
Feb 1
Simulation in ICU - #Empathy👇

A doctor volunteer trying to understand what it’s like to be tied down & sedated.

More & more we must dive down into what we do to others to understand their experiences

To improve our care…#A2Fbundle
Asking:

“What is causing their agitation? How can you respond to it? Do they have contraindications to mobility? How do you start?”
She @DaytonICU gives complex scenarios & walks us through the process of asking, “What is their RASS? Why are we concerned about delirium? What are their risk factors for ICUAW? Why are we concerned about ICUAW? Do they have an indication for sedation?”

“Now what do you do⁉️”
Read 4 tweets

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