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LashuelNeuroLab Profile picture
LashuelNeuroLab
@LashuelLab
Working at the interface of Chemistry and Biology to develop novel biomarkers and therapies for neurodegenerative diseases. RT =/= endorsement
Jan 12, 2020 • 14 tweets • 5 min read
Check out our latest paper on @biorxivpreprint!

Phosphorylation of the overlooked #tyrosine 310 regulates the structure, #aggregation, and #microtubule- and #lipid-binding properties of #Tau

biorxiv.org/content/10.110…

Short #thread!

#AcademicTwitter #biochemistry #threadstory Tau misfolding and aggregation are implicated in tauopathies such as #Alzheimers and #PSP. Tau is extensively post-translationally modified and aberrant pattern of PTMs are found in disease. Tyrosine PTMs have received the least attention, especially Y310.