Discover and read the best of Twitter Threads about #lipid

Most recents (8)

1) Welcome to @cardiomet_CE's new series on #lipid management! This is a 10-#tweetorial program, all #accredited, that will cover it all. Our first expert author is Paul Thompson MD @PaulDThompsonMD, esteemed #cardiologist from @hartfordhosp @UConn Med & now @MGHHeartHealth ! Image
2) This #tweetorial, accredited for #CME/CE and intended for #physicians #physicianassociates #nurses #nursepractitioners #pharmacists is supported by an educational grant from Esperion Therapeutics. See faculty disclosures at cardiometabolic-ce.com/disclosures/.
3) @PaulDThompsonMD took on education re mechanisms & use of ezetimibe & bempedoic acid. He proposes a case: 45 ♂️ w/history of inferior wall #MI treated with primary angioplasty.
Read 57 tweets
1) Welcome to @cardiomet_CE's series on #lipid management! This is a 10-#tweetorial program, all #accredited, that will cover IT ALL. The expert author for this module is Robert Giugliano MD @ @rgiugliano, renowned #cardiologist from @BrighamWomens & @harvardmed ! Image
2) This #tweetorial, accredited for #CME/CE and intended for #physicians #physicianassociates #nurses #nursepractitioners #pharmacists is supported by an educational grant from Esperion Therapeutics. See faculty disclosures at cardiometabolic-ce.com/disclosures/.
3) @rgiugliano is going to discuss care of patients taking #statins who still have residual atherosclerotic cardiovascular disease #ASCVD risk.
Read 48 tweets
#WeekendLecture
Intracranial Atherosclerotic Disease #ICAD

#ICAD leads to changes ranging from minor wall thickening to #hemodynamically significant luminal stenosis and is one of the most #common causes of #stroke worldwide
ahajournals.org/doi/10.1161/CI…

🧵 Image
#WeekendLecture
#ICAD

✅10% of stroke, based on autopsy studies
bit.ly/3v6Lhrd
✅More prevalent in #African Americans, #Hispanics, and #Asians as compared with whites
bit.ly/3AuSiDt

Other risk factors in table Image
#WeekendLecture
#ICAD

In postmortem studies
👉degree of luminal #stenosis
👉% of the plaques containing >40% #lipid area
👉prevalence of intraplaque #hemorrhage, #neovasculature and #thrombus,
were higher in those #plaques associated with #infarct
🔹karger.com/Article/Abstra… Image
Read 13 tweets
1/ Initial #Lipid thoughts...

(@KevinH_PhD's new study - osf.io/preprints/nutr…)

Of course, the panels follow the pattern I'd speculate given the Lipid Energy Model (see CholesterolCode.com/model), but per the model, body fat/metb status is very relevant context, so note bf%...
2/ This isn't a critique on their study design or its population. But I'd bet if this same study were performed on average or leaner/athletic types, we'd see a more pronounced shift in lipid values for each diet. (ie. See Volek and Phinney typical study population for comparison)
3/ Now, what I *do* want to highlight is the Free Fatty Acids going up much more with ABLC Diet vs the PBLF diet
Baseline 328±48
ABLC 760±48
PBLF 508±48

Yet Triglycerides fell for ABLC, increased for PBLF
Baseline 75±4.5
ABLC 63.4±4.5
PBLF 93.3±4.5

Why is this so important?...
Read 11 tweets
Study finds a “striking buildup of lipid droplets in microglia w/ aging in mouse/human #brains.” The cells, called ‘lipid-droplet-accumulating #microglia (LDAM), are defective in phagocytosis, produce high levels of ROS + secrete proinflammatory cytokines: nature.com/articles/s4159… ImageImage
2/ Worth noting that persistent #viruses target #lipid signaling, synthesis + metabolism to remodel host cells like microglia into an environment optimal for their replication 👉 Indeed viral infection of LDAM cells cld explain ROS + proinflammatory state: ncbi.nlm.nih.gov/pmc/articles/P… ImageImage
3/ Or since LPS induced lipid formation in the study, cld bacterial infection be involved? (ncbi.nlm.nih.gov/pmc/articles/P…) 👉 Especially w/ more teams reporting bacteria inside astrocytes/glia in the brain? (sciencemag.org/news/2018/11/d…) Any thoughts @wysscoray @CarolynBertozzi?
Read 3 tweets
Check out our latest paper on @biorxivpreprint!

Phosphorylation of the overlooked #tyrosine 310 regulates the structure, #aggregation, and #microtubule- and #lipid-binding properties of #Tau

biorxiv.org/content/10.110…

Short #thread!

#AcademicTwitter #biochemistry #threadstory
Tau misfolding and aggregation are implicated in tauopathies such as #Alzheimers and #PSP. Tau is extensively post-translationally modified and aberrant pattern of PTMs are found in disease. Tyrosine PTMs have received the least attention, especially Y310.
Tau has 5 tyrosines, and Y310 is in the crucial position within the aggregation-prone MT- and lipid-binding repeat domain. It compacts and folds into beta-sheet structure. We asked:

How would addition of bulky negatively charged phosphogroups to tyrosines impact Tau properties?
Read 14 tweets
Our latest paper fresh out in @ATHjournal! We asked: "If we used an #AI algorithm to group individuals based on similar blood profile of 44 #lipid measurements, could we improve coronary #heartdisease risk prediction?" Turns out: no.

Thread! 🚨 (1/13)

atherosclerosis-journal.com/article/S0021-…
We looked to see if we could detect subgroups in the population that would have a) similar blood profiles across 14 lipoprotein subclasses and b) possible differences in CHD risk. The algorithm we use is called a self-organising map (SOM)

See: academic.oup.com/ije/article-ab… (2/13)
SOM is a tool for multivariate subgrouping. Essentially the user puts in variables and the algorithm groups individuals based on similarity of these inputs. Here's a rough emoji-schematic of how this applies to population cohorts (3/13)
Read 13 tweets
😮! These findings significantly expand on a central mechanism by which persistent #pathogens drive chronic disease 👉 Namely, the ability of intracellular pathogens to dysregulate host receptor actvity in a manner that alters downstream pathway signaling: stke.sciencemag.org/content/12/599… ImageImage
2/ Specifically they found that a “vast number” of intracellular pathogens can bind (or create #proteins that bind) #receptor tyrosine kinases (RTKs) on the surface of host cells 👉 This facilitates their entry into the host cell + dysregulates cell signaling in numerous ways. Image
3/ Look at the figure below, which lists dozens + dozens of human #viruses with this capacity 👉 These viruses can dysregulate RTK activity to facilitate their entry into host cells by clustering in #lipid rafts, adjusting cytoskeletal dynamics, modulating endocytosis etc etc Image
Read 4 tweets

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