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Recent
Anti cancer progress
Researchers have turned a common food-borne bacterium into a microscopic courier that delivers cancer killing toxins directly inside colorectal cancer cells.
They engineered Listeria monocytogenes, a bacterium known for causing food poisoning, to carry saporin, a ribosome inactivating toxin that kills cells by shutting down protein production.
Normally saporin cannot enter cells easily. But Listeria naturally invades host cells and escapes into the cytoplasm, allowing it to smuggle the toxin inside tumor cells.
The researchers chemically attached saporin to the bacterial surface, creating a living drug delivery system that releases the toxin once inside cancer cells.
Why this matters?
In experiments with human colorectal cancer cells and mouse tumor models, the bacteria delivered toxin caused strong cancer cell death and significantly reduced tumor growth, while also triggering immune cell infiltration into tumors.
If future human studies succeed, this approach could lead to bacteria based cancer therapies that deliver powerful drugs directly into tumor cells instead of damaging healthy tissue with traditional chemotherapy.
Researchers have turned a common food-borne bacterium into a microscopic courier that delivers cancer killing toxins directly inside colorectal cancer cells.
They engineered Listeria monocytogenes, a bacterium known for causing food poisoning, to carry saporin, a ribosome inactivating toxin that kills cells by shutting down protein production.
Normally saporin cannot enter cells easily. But Listeria naturally invades host cells and escapes into the cytoplasm, allowing it to smuggle the toxin inside tumor cells.
The researchers chemically attached saporin to the bacterial surface, creating a living drug delivery system that releases the toxin once inside cancer cells.
Why this matters?
In experiments with human colorectal cancer cells and mouse tumor models, the bacteria delivered toxin caused strong cancer cell death and significantly reduced tumor growth, while also triggering immune cell infiltration into tumors.
If future human studies succeed, this approach could lead to bacteria based cancer therapies that deliver powerful drugs directly into tumor cells instead of damaging healthy tissue with traditional chemotherapy.
Cancer is more evil than you thought. 🚨🤨!
BREAKING: AI can now diagnose diseases like a Harvard doctor (for free).
Here are 10 insane Perplexity prompts that replace $500/hour medical consultations:
(Save for later)
Here are 10 insane Perplexity prompts that replace $500/hour medical consultations:
(Save for later)
1/ The Complete Symptom Analyzer
Stop Googling your symptoms and reading WebMD horror stories. Use this:
"You are a board-certified internal medicine physician with 20 years of clinical experience at a top academic medical center. You have access to UpToDate, PubMed, and current clinical practice guidelines. Cite medical literature where relevant. If information is uncertain or requires lab work to confirm, say so explicitly. Do not diagnose -- provide a clinical reasoning framework.
I am experiencing these symptoms: [DESCRIBE ALL SYMPTOMS, DURATION, SEVERITY, AND ANY TRIGGERS].
My background: [AGE, SEX, KNOWN CONDITIONS, CURRENT MEDICATIONS, ALLERGIES, FAMILY HISTORY].
Step 1 -- Differential Diagnosis:
→ List the top 5 most likely conditions that match these symptoms, ranked by probability
→ For each condition: why it fits, what makes it more or less likely, and the typical presentation
→ Flag any red-flag symptoms that require immediate medical attention
Step 2 -- Key Questions a Doctor Would Ask:
→ What additional information would narrow down the diagnosis?
→ What symptoms should I monitor for that would change the urgency?
Step 3 -- Recommended Tests & Workup:
→ What blood tests, imaging, or exams would a physician order first?
→ What is each test looking for specifically?
→ Approximate cost range for each test without insurance
Step 4 -- What To Do Right Now:
→ Immediate self-care steps for symptom relief
→ OTC medications that may help (with standard dosing)
→ What to avoid that could make it worse
Step 5 -- When To See a Doctor vs. ER:
→ Specific warning signs that mean 'go to the ER now'
→ Signs that mean 'book a doctor appointment this week'
→ Signs that mean 'monitor at home for now'
Format with clear headers and flag any information that is general guidance, not a personal diagnosis."
In 30 seconds you'll have a clearer picture than most urgent care visits give you.
Stop Googling your symptoms and reading WebMD horror stories. Use this:
"You are a board-certified internal medicine physician with 20 years of clinical experience at a top academic medical center. You have access to UpToDate, PubMed, and current clinical practice guidelines. Cite medical literature where relevant. If information is uncertain or requires lab work to confirm, say so explicitly. Do not diagnose -- provide a clinical reasoning framework.
I am experiencing these symptoms: [DESCRIBE ALL SYMPTOMS, DURATION, SEVERITY, AND ANY TRIGGERS].
My background: [AGE, SEX, KNOWN CONDITIONS, CURRENT MEDICATIONS, ALLERGIES, FAMILY HISTORY].
Step 1 -- Differential Diagnosis:
→ List the top 5 most likely conditions that match these symptoms, ranked by probability
→ For each condition: why it fits, what makes it more or less likely, and the typical presentation
→ Flag any red-flag symptoms that require immediate medical attention
Step 2 -- Key Questions a Doctor Would Ask:
→ What additional information would narrow down the diagnosis?
→ What symptoms should I monitor for that would change the urgency?
Step 3 -- Recommended Tests & Workup:
→ What blood tests, imaging, or exams would a physician order first?
→ What is each test looking for specifically?
→ Approximate cost range for each test without insurance
Step 4 -- What To Do Right Now:
→ Immediate self-care steps for symptom relief
→ OTC medications that may help (with standard dosing)
→ What to avoid that could make it worse
Step 5 -- When To See a Doctor vs. ER:
→ Specific warning signs that mean 'go to the ER now'
→ Signs that mean 'book a doctor appointment this week'
→ Signs that mean 'monitor at home for now'
Format with clear headers and flag any information that is general guidance, not a personal diagnosis."
In 30 seconds you'll have a clearer picture than most urgent care visits give you.
2/ The Medication Interaction Checker
Every year 1.3 million people are injured by medication errors. Catch them before they happen:
"You are a clinical pharmacist with 15 years of experience at a major hospital system. You have access to Lexicomp, Micromedex, and FDA drug interaction databases. Cite severity levels for every interaction. Do not guess -- if an interaction is not well-documented, say so.
Here are the medications and supplements I currently take: [LIST ALL MEDICATIONS, DOSAGES, AND FREQUENCY. INCLUDE SUPPLEMENTS, VITAMINS, AND OTC DRUGS].
Step 1 -- Interaction Matrix:
→ Check every possible drug-drug interaction between my medications
→ Rate each interaction: Major (avoid) / Moderate (monitor) / Minor (low risk)
→ Explain the mechanism of each interaction in plain English
→ Flag any combination that requires immediate doctor consultation
Step 2 -- Food & Drink Interactions:
→ Any foods I should avoid with these medications (grapefruit, dairy, alcohol, caffeine, etc.)
→ Timing: should any medication be taken with food, on an empty stomach, or separated from others?
Step 3 -- Side Effect Risk Profile:
→ Most common side effects for each medication (with approximate % occurrence)
→ Overlapping side effects between medications that compound risk
→ Rare but serious side effects I should watch for
Step 4 -- Optimization Suggestions:
→ Is the timing of my medications optimal? Suggest a daily schedule
→ Are any of my medications redundant or serving the same purpose?
→ Are there known alternatives with fewer interactions?
Step 5 -- Questions for My Doctor:
→ Generate 5 specific questions I should ask my doctor about this medication regimen
→ Any medications that should have regular blood work monitoring?
Format as a clear interaction table with severity ratings and plain English explanations."
This is what your pharmacist checks in 10 seconds. Now you can verify it yourself.
Every year 1.3 million people are injured by medication errors. Catch them before they happen:
"You are a clinical pharmacist with 15 years of experience at a major hospital system. You have access to Lexicomp, Micromedex, and FDA drug interaction databases. Cite severity levels for every interaction. Do not guess -- if an interaction is not well-documented, say so.
Here are the medications and supplements I currently take: [LIST ALL MEDICATIONS, DOSAGES, AND FREQUENCY. INCLUDE SUPPLEMENTS, VITAMINS, AND OTC DRUGS].
Step 1 -- Interaction Matrix:
→ Check every possible drug-drug interaction between my medications
→ Rate each interaction: Major (avoid) / Moderate (monitor) / Minor (low risk)
→ Explain the mechanism of each interaction in plain English
→ Flag any combination that requires immediate doctor consultation
Step 2 -- Food & Drink Interactions:
→ Any foods I should avoid with these medications (grapefruit, dairy, alcohol, caffeine, etc.)
→ Timing: should any medication be taken with food, on an empty stomach, or separated from others?
Step 3 -- Side Effect Risk Profile:
→ Most common side effects for each medication (with approximate % occurrence)
→ Overlapping side effects between medications that compound risk
→ Rare but serious side effects I should watch for
Step 4 -- Optimization Suggestions:
→ Is the timing of my medications optimal? Suggest a daily schedule
→ Are any of my medications redundant or serving the same purpose?
→ Are there known alternatives with fewer interactions?
Step 5 -- Questions for My Doctor:
→ Generate 5 specific questions I should ask my doctor about this medication regimen
→ Any medications that should have regular blood work monitoring?
Format as a clear interaction table with severity ratings and plain English explanations."
This is what your pharmacist checks in 10 seconds. Now you can verify it yourself.
Cheltenham Friday 🐐🧵
Awful day for me yesterday lads!
Other than Woodhoh - not one return!
Did anyone have a good day?
My thoughts on each race today:
Other than Woodhoh - not one return!
Did anyone have a good day?
My thoughts on each race today:
13:20) Triumph Hurdle
2m1f juvenile hurdle (for 4 year olds).
What a race this is. All of the future superstars going at eachother. A star is normally born here after big name winners in recent years like Tiger Roll, Defi Du Seuil and Lossiemouth to name just a handful.
Willie has won this the last 4 years (and 5 of the last 6) and it’s no shock to see him have the two market leaders here.
Selma De Vary to me looks like she’s got proper yard tax on here mind at 7/2. Seems far too short. She didn’t look great in France and was comfortably beaten Narciso Has (the antepost favourite for this race) on stable debut. Looks to me that she could be easily beaten by a stronger progressive horse and I don’t think a 7lb claim will be enough to help her in the field. Watch her romp home haha.
Stablemate Proactif looks the better of the two IMO. Stronger form lines in France and won nicely on yard debut beating some bloody good horses. I’m surprised this one is drifting and isn’t favourite out of the two… but again, 4/1 even seems too short to me.
Anyway for me it’s all about Minella Study. Absolutely romped home for me here in December and what a spectacle that was. Beat One Horse Town (who was on a 5timer) by 10L and absolutely shot up the hill to go away and beat Winston Junior (who has since won at Ascot and come 2nd in Fred Winter here in Tuesday) by over 6L. Looks to be improving and with that course form on side I’m loving 6/1 for a nice each way bet. Of course these juvenile races are full of unexposed horses and you can never really know - but I would be shocked if he comes out of the top4.
I think Maestro Conti or Highland Crystal may even follow him home in second you know.
Maestro Conti also has course for after romping home here in January, although One Horse Town was a lot closer than Minella Study’s demolition job. Strong from race though nonetheless with Minella Yoga, Tenter Le Tout and La Luna Artista all being denied a hattrick (the latter has since followed up too). Skelton’s best chance to win this for the first time and should go very close.
Highland Crystal is an unbeaten 3-3 and has looked a rocket. Strong form lines too. Beat Saratoga LTO who won the Fred Winter on Tuesday. Looks ground versatile and should again go very close.
Would it be absolutely mental to put on a quid on Minella Study to win and Maestro Conti and Highland Crystal to both come top3 at 180/1? I think there’s a small chance of that happening you know.
Who really knows though eh? So many unexposed horses in this field who could be absolute rockets. Look at Poniros last year winning at 100/1. Madness.
Macho Man looked good on debut in France but lost to Proactif on yard debut and looks third string to me here at 9/1 looks too short.
Minella Academy looked good on debut but that was a poor race and the form hasn’t been franked. 16/1 for a reason
Kai Lung was ahead of Saratoga, Lynches Knock and Mon Creuset on yard/jumps debut and that is strong form. First one in the race so far that I think is overpriced at 28/1. Maybe even massively overpriced. I won’t be getting on myself but could easily see why someone would have a go on it.
The rest of the field surely don’t stand a chance? The only one that I think could be overpriced is Indian River (at 100/1) who is 3-3 unbeaten over hurdles. He beat absolutely nothing though and couldn’t get in to the Fred Winter though so surely doesn’t have a chance here.
So yeah I’m pretty set on Minella Study. Will have in an each way single and in a couple each way multis at 6/1.
On this race I may play a couple of build a bets too for extra fun:
Minella Study to win and Maestro Conti / Highland Crystal to both come top3 at 180/1
Minella Study top 3 and Maestro Conti / Highland Crystal to both come top5 at 14/1
Who is everyone else going for in this?
Anyone with me on Minella Study? Or really against me?
2m1f juvenile hurdle (for 4 year olds).
What a race this is. All of the future superstars going at eachother. A star is normally born here after big name winners in recent years like Tiger Roll, Defi Du Seuil and Lossiemouth to name just a handful.
Willie has won this the last 4 years (and 5 of the last 6) and it’s no shock to see him have the two market leaders here.
Selma De Vary to me looks like she’s got proper yard tax on here mind at 7/2. Seems far too short. She didn’t look great in France and was comfortably beaten Narciso Has (the antepost favourite for this race) on stable debut. Looks to me that she could be easily beaten by a stronger progressive horse and I don’t think a 7lb claim will be enough to help her in the field. Watch her romp home haha.
Stablemate Proactif looks the better of the two IMO. Stronger form lines in France and won nicely on yard debut beating some bloody good horses. I’m surprised this one is drifting and isn’t favourite out of the two… but again, 4/1 even seems too short to me.
Anyway for me it’s all about Minella Study. Absolutely romped home for me here in December and what a spectacle that was. Beat One Horse Town (who was on a 5timer) by 10L and absolutely shot up the hill to go away and beat Winston Junior (who has since won at Ascot and come 2nd in Fred Winter here in Tuesday) by over 6L. Looks to be improving and with that course form on side I’m loving 6/1 for a nice each way bet. Of course these juvenile races are full of unexposed horses and you can never really know - but I would be shocked if he comes out of the top4.
I think Maestro Conti or Highland Crystal may even follow him home in second you know.
Maestro Conti also has course for after romping home here in January, although One Horse Town was a lot closer than Minella Study’s demolition job. Strong from race though nonetheless with Minella Yoga, Tenter Le Tout and La Luna Artista all being denied a hattrick (the latter has since followed up too). Skelton’s best chance to win this for the first time and should go very close.
Highland Crystal is an unbeaten 3-3 and has looked a rocket. Strong form lines too. Beat Saratoga LTO who won the Fred Winter on Tuesday. Looks ground versatile and should again go very close.
Would it be absolutely mental to put on a quid on Minella Study to win and Maestro Conti and Highland Crystal to both come top3 at 180/1? I think there’s a small chance of that happening you know.
Who really knows though eh? So many unexposed horses in this field who could be absolute rockets. Look at Poniros last year winning at 100/1. Madness.
Macho Man looked good on debut in France but lost to Proactif on yard debut and looks third string to me here at 9/1 looks too short.
Minella Academy looked good on debut but that was a poor race and the form hasn’t been franked. 16/1 for a reason
Kai Lung was ahead of Saratoga, Lynches Knock and Mon Creuset on yard/jumps debut and that is strong form. First one in the race so far that I think is overpriced at 28/1. Maybe even massively overpriced. I won’t be getting on myself but could easily see why someone would have a go on it.
The rest of the field surely don’t stand a chance? The only one that I think could be overpriced is Indian River (at 100/1) who is 3-3 unbeaten over hurdles. He beat absolutely nothing though and couldn’t get in to the Fred Winter though so surely doesn’t have a chance here.
So yeah I’m pretty set on Minella Study. Will have in an each way single and in a couple each way multis at 6/1.
On this race I may play a couple of build a bets too for extra fun:
Minella Study to win and Maestro Conti / Highland Crystal to both come top3 at 180/1
Minella Study top 3 and Maestro Conti / Highland Crystal to both come top5 at 14/1
Who is everyone else going for in this?
Anyone with me on Minella Study? Or really against me?
NEW: My deep dive into how top DC strategist Juleanna Glover corresponded with Jeffrey Epstein on centrist politics, Tesla and Steve Bannon during a 15-month period shortly before his death in 2019. She says it was all in service of tanking Trump. politico.com/news/2026/03/1…
Glover took a stab at helping reintroduce Epstein to parts of mainstream society and made a brief attempt to fashion him into a champion of democracy, arranging a meeting with the head of the nonprofit group Freedom House in 2017. (The group never accepted money from him.)
Glover’s and Epstein’s relationship encompassed several dozen emails, two in-person meetings and a number of calls, according to a POLITICO review of the Epstein files released by DOJ. Her name returns 191 results in the files, although many mentions are duplicates.
@CreepnCat Good God, are they still going on about pups and pup hoods? Pup Play "officially" began at IML 1986, 3 years before the first ConFurEnce, and they are not in conflict; they draw from and enrich and sustain each other, and each is now practiced by millions around the world. 1/
@CreepnCat Many of us participate in both practices and are fully invested in both communities. This natural unity and harmony is key to our affinity for the activity, and we're puzzled by the recurring hateful discourse, the calls for separation and worse - 2/
@CreepnCat Pup Play and the Furry Fandom are here for our enjoyment, gifts to us really, a small vacation from our daily grind, and as we play and rest and become a new creature for a time, we deepen and enrich our lives in a meaningful way, even profound at times - 3/
1/ In recent weeks, an entire genre has sprung up on Telegram of Russian bloggers suddenly realising that they live in a repressive dictatorship. They complain bitterly that they were "fools", they are being "enslaved", and forced to endure a "cultural counter-revolution". ⬇️
2/ The forthcoming ban on Telegram – likely to be announced on 1 April – appears to have woken up many Russian bloggers to the way the Russian government is systematically attacking free speech. 'Under the ice' predicts catastrophe:
3/ "In general, the desire to confine all citizens of the country to a sterile information bubble, eliminating the use of inappropriate social networks, books, music, and films, will have the most devastating consequences for the state itself.
In 2023, Chelsea FC gave players 7–8 year contracts.
Fans thought it was RECKLESS.
In reality, it was a clever accounting strategy to stretch €1 BILLION in transfers.
Here's how the trick worked (and why UEFA HAD TO CHANGE the rules).
🧵 - A thread by @OfficesideFC
Fans thought it was RECKLESS.
In reality, it was a clever accounting strategy to stretch €1 BILLION in transfers.
Here's how the trick worked (and why UEFA HAD TO CHANGE the rules).
🧵 - A thread by @OfficesideFC
1/10 🧵
After Todd Boehly bought Chelsea in 2022, the club spent over €1B on players in 18 months.
Everyone asked: "How is this allowed under Financial Fair Play?"
Pundits called it reckless gambling.
The reality was more interesting — it was a smart accounting strategy.
After Todd Boehly bought Chelsea in 2022, the club spent over €1B on players in 18 months.
Everyone asked: "How is this allowed under Financial Fair Play?"
Pundits called it reckless gambling.
The reality was more interesting — it was a smart accounting strategy.
2/10 🧵
In football finance, transfer fees aren’t recorded immediately.
They're amortized over the length of the contract.
Example: A €100M transfer on a 5-year deal.
Accounting cost per year: €100M ÷ 5 = €20M
In football finance, transfer fees aren’t recorded immediately.
They're amortized over the length of the contract.
Example: A €100M transfer on a 5-year deal.
Accounting cost per year: €100M ÷ 5 = €20M
GOODBYE, FUND MANAGERS. GOODBYE, BLOOMBERG TERMINAL.
No more $24,000/year subscriptions.
Claude just turned my laptop into a private quant analyst.
Here are 07 prompts to build your own hedge fund at home ↓
No more $24,000/year subscriptions.
Claude just turned my laptop into a private quant analyst.
Here are 07 prompts to build your own hedge fund at home ↓
1. Portfolio Hedging Strategy
Prompt:
“My portfolio is exposed to [SECTOR/MARKET]. Using current options data and available inverse ETFs, design an efficient hedge: recommended instrument, hedge size (% of portfolio), annualized cost, scenario to activate it, and sources for volatility data.”
Prompt:
“My portfolio is exposed to [SECTOR/MARKET]. Using current options data and available inverse ETFs, design an efficient hedge: recommended instrument, hedge size (% of portfolio), annualized cost, scenario to activate it, and sources for volatility data.”
2. Institutional Positioning Analysis
Prompt:
“Using recent 13F data (WhaleWisdom, Dataroma) and news, tell me which sectors/stocks the top 10 hedge funds are accumulating this quarter vs. the previous quarter. Present new entries, full exits, and increased positions, including the fund name and sources.”
Prompt:
“Using recent 13F data (WhaleWisdom, Dataroma) and news, tell me which sectors/stocks the top 10 hedge funds are accumulating this quarter vs. the previous quarter. Present new entries, full exits, and increased positions, including the fund name and sources.”
Supreme Court hears the case regarding mandatory requirement of three years' practice at the Bar as a uniform eligibility condition for entry-level judicial service posts
Sr Adv Sidharth Bhatnagar, Amicus: High Courts are of the view that three years should remain. But for disability ..some accessibility needs to be given. Allahabad HC says it is not capable at the moment it is too early for a view. Delhi HC says three year practice has been reintroduced as in terms of SC judgment. Committee says relaxation for disabled may lead to disparity
Sr Adv Sidharth Bhatnagar, Amicus: High Courts are of the view that three years should remain. But for disability ..some accessibility needs to be given. Allahabad HC says it is not capable at the moment it is too early for a view. Delhi HC says three year practice has been reintroduced as in terms of SC judgment. Committee says relaxation for disabled may lead to disparity
Amicus: Faizan Mustafa for CNLU says no experience needed at all and should be done away with.
Sr Adv Pinky Anand: This practice is not even consistent to their skills of being adjudicators. Thus this is a Roadblock. Average age of aspirant will be 29.
#SupremeCourt to shortly hear review petitions against judgement holding that 3 year practice is mandatory for entering into judicial services.
Bench: CJI Surya Kant, Justice August George Masih and Justice K Vinod Chandran
Bench: CJI Surya Kant, Justice August George Masih and Justice K Vinod Chandran
During the hearing last month, the CJI had orally commented that the three year rule was disproportionately affecting women candidates.
livelaw.in/top-stories/su…
livelaw.in/top-stories/su…
Responding to the Court's call for suggestions, several High Courts have supported retaining the condition while some others have supported relaxing the mandate for specially abled candidates.
livelaw.in/top-stories/se…
livelaw.in/top-stories/se…
Trump opened Pandora’s box, unleashing forces that he & we Americans cannot control.
Instead of forcing Iran’s regime to cry uncle, he’s given its isolated ideologues the chance to grab the global economy by the cojones & twist until we squeal.
Every way out of this looks bad:
Instead of forcing Iran’s regime to cry uncle, he’s given its isolated ideologues the chance to grab the global economy by the cojones & twist until we squeal.
Every way out of this looks bad:
1. The status quo is untenable. Iran cannot be allowed to destroy its neighbours who are actually integral to the global economy, or to strangle the Strait of Hormuz.
2. Breaking its grip on the SoH could require a ground invasion & that will be a bloodbath, slog & quagmire.
2. Breaking its grip on the SoH could require a ground invasion & that will be a bloodbath, slog & quagmire.
Iran’s regime has a low center of gravity & won’t be toppled by airstrikes.
It hasn’t yet activated its regional pinch hitter & geostrategic MVP, the Houthis, to block Bab al-Mandab. But it will in a bind, ensuring that this economic crisis will likely worsen before it improves.
It hasn’t yet activated its regional pinch hitter & geostrategic MVP, the Houthis, to block Bab al-Mandab. But it will in a bind, ensuring that this economic crisis will likely worsen before it improves.
“If you keep on investigating when will charges be heard? For two years you cannot sit when somebody is in jail”: Delhi High Court to Delhi government in bail plea of Aam Aadmi Party (AAP) leader Naresh Balyan in connection with his arrest under Maharashtra Control of Organised Crime Act (MCOCA).
The matter was listed before Justice Swarana Kanta Sharma. The Court today heard arguments on behalf of Balyan. Senior Advocate Rebecca John apeared for Balyan.
John - They took my voice samples. They have not taken voice samples of anybody else. We dont know if it is gangster, they are claiming that it is a gangster. Who is this other person?
