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What is a dysregulated nervous system?
Dr. Robert Sapolsky spent 30 years studying stress in primates and humans.
His conclusion: "The stress response is more dangerous than the stressors themselves."
Few understand what this means for their body.
Here's the short version: 🧵
Dr. Robert Sapolsky spent 30 years studying stress in primates and humans.
His conclusion: "The stress response is more dangerous than the stressors themselves."
Few understand what this means for their body.
Here's the short version: 🧵
Your body is supposed to spend roughly 90% of its time in homeostasis. Calm. Recovering. Rebuilding tissue. Clearing inflammation. Filing memories properly.
For most people with chronic pain, fatigue, IBS, or brain fog, that ratio is inverted.
Their nervous system runs in threat mode almost constantly. Not because they're in danger. Because the brain got conditioned to treat normal life as a threat — and the conditioning stuck.
For most people with chronic pain, fatigue, IBS, or brain fog, that ratio is inverted.
Their nervous system runs in threat mode almost constantly. Not because they're in danger. Because the brain got conditioned to treat normal life as a threat — and the conditioning stuck.
This is how it happens:
A period of stress, illness, injury, or emotional overwhelm activates the brain's danger response. That's normal. The problem starts when the stressor lasts long enough — weeks, months — for the brain to start treating the stress response itself as the new default.
The limbic system, which controls threat detection, physically rewires. Neural pathways that fire together wire together. The alarm circuit gets stronger with every repetition. Eventually it runs on autopilot.
Neuroscientists call this central sensitization. Your threat detector recalibrated itself to "high" and lost the off switch.
A period of stress, illness, injury, or emotional overwhelm activates the brain's danger response. That's normal. The problem starts when the stressor lasts long enough — weeks, months — for the brain to start treating the stress response itself as the new default.
The limbic system, which controls threat detection, physically rewires. Neural pathways that fire together wire together. The alarm circuit gets stronger with every repetition. Eventually it runs on autopilot.
Neuroscientists call this central sensitization. Your threat detector recalibrated itself to "high" and lost the off switch.
The World Order:
Empires don’t announce intentions. The rearrange the world quietly and call it necessity. We are not watching separate wars, Ukraine, Iran, trade disputes, energy shocks, each unfolding in isolation, each with its own beginning and end. They are connected.
Empires don’t announce intentions. The rearrange the world quietly and call it necessity. We are not watching separate wars, Ukraine, Iran, trade disputes, energy shocks, each unfolding in isolation, each with its own beginning and end. They are connected.
They are the same conflict, fought at a distance so that the final war never has to be fought at all. This is how the Cold War, stayed cold. There is a language capable of describing it, Realism,the kind practiced by Kissinger, Zhao Enlai, Lee Kuan Yew, and all great statesman.
Power is control over what others cannot live without. that thing is oil, but now it is also gas, electricity, and the silent architecture of compute. Energy, money, compute and whoever governs that axis does not merely influence the world, they shape its boundaries.
1/ The Ukraine war is a "dead end" which "could last for a hundred years", according to a gloomy Russian commentary. The transparency of the battlefield and its domination by drones has made large offensives "downright impossible" and is causing vast numbers of casualties. ⬇️
2/ 'Voenkor Kotenok' has written a long and detailed analysis of the situation at the front lines, following similarly gloomy outlooks by other warbloggers (see the thread below).
3/ "I have repeatedly pointed out that the front in the Ukrainian theatre of military operations is in a stalemate. This situation took shape last year, marked by the Battle of Pokrovsk.
A leading neuroscientist just confirmed a “wild conspiracy theory” about incandescent lights and LED bulbs.
Dr. Andrew Huberman told Bill Maher that the long wavelengths in incandescents can improve your vision and “charge your mitochondria.”
Conversely, LED bulbs are “causing disruptions in mitochondrial function.”
DR. ANDREW HUBERMAN: “Your mitochondria function better, you increase ATP production, your metabolism increases in the presence of red light, long wavelength light to the skin.”
“Shine long wavelength light on somebody, watch blood glucose levels in a blood glucose test, and it’s blunted.”
“Now, the LED lights that are commonly used now… that short wavelength light, in the absence of long wavelength light, has been shown to damage the mitochondria.”
“This used to be considered crazy. This was like chemtrail crazy, right?”
“But now we’re starting to see from animal studies and human studies, from Glenn Jeffreys and others, that people’s vision gets better when they get in front of an incandescent bulb once a day.”
“If they get sunlight, which also has long-wavelength light, your vision improves because of improvements in mitochondria.”
Scientific data backs Huberman up: thefocalpoints.com/p/new-study-su…
The Biden administration quietly pushed incandescents out of the market through aggressive energy regulations.
But you can still find them online today if you look hard enough.
If something as simple as your light bulb can disrupt your mitochondria, what else is quietly keeping your cells stuck in survival mode?
Once you understand how this works, the root cause of chronic disease starts to look very different. 🧵
Dr. Andrew Huberman told Bill Maher that the long wavelengths in incandescents can improve your vision and “charge your mitochondria.”
Conversely, LED bulbs are “causing disruptions in mitochondrial function.”
DR. ANDREW HUBERMAN: “Your mitochondria function better, you increase ATP production, your metabolism increases in the presence of red light, long wavelength light to the skin.”
“Shine long wavelength light on somebody, watch blood glucose levels in a blood glucose test, and it’s blunted.”
“Now, the LED lights that are commonly used now… that short wavelength light, in the absence of long wavelength light, has been shown to damage the mitochondria.”
“This used to be considered crazy. This was like chemtrail crazy, right?”
“But now we’re starting to see from animal studies and human studies, from Glenn Jeffreys and others, that people’s vision gets better when they get in front of an incandescent bulb once a day.”
“If they get sunlight, which also has long-wavelength light, your vision improves because of improvements in mitochondria.”
Scientific data backs Huberman up: thefocalpoints.com/p/new-study-su…
The Biden administration quietly pushed incandescents out of the market through aggressive energy regulations.
But you can still find them online today if you look hard enough.
If something as simple as your light bulb can disrupt your mitochondria, what else is quietly keeping your cells stuck in survival mode?
Once you understand how this works, the root cause of chronic disease starts to look very different. 🧵
Most chronic illnesses are still treated as isolated problems.
A hormone imbalance.
An autoimmune condition.
A neurological disorder.
But a pattern is emerging across all of them: Cells stop functioning normally, and they never switch back.
Once you understand this, the entire model of chronic disease looks a whole lot different.
A hormone imbalance.
An autoimmune condition.
A neurological disorder.
But a pattern is emerging across all of them: Cells stop functioning normally, and they never switch back.
Once you understand this, the entire model of chronic disease looks a whole lot different.
Every cell in your body has two core modes: Normal function and survival.
When a threat is detected—whether from infection, toxins, injury, or prolonged stress—mitochondria shift away from energy production and toward defense, reducing cellular output to prioritize survival.
It’s important to understand that this is not dysfunction.
It’s an adaptive response designed to keep the cell alive under stress.
When a threat is detected—whether from infection, toxins, injury, or prolonged stress—mitochondria shift away from energy production and toward defense, reducing cellular output to prioritize survival.
It’s important to understand that this is not dysfunction.
It’s an adaptive response designed to keep the cell alive under stress.
Gems of UPA. A Mega Thread🧵
Trust Pakistan ✅
Why take action when assurance is all you need ☺️
51% of window tinting reviews go completely unanswered. Over half. Your future customers are reading those ignored complaints right now and calling someone else 🧵👇
I analyzed 736 reviews across 5 real window tinting businesses in Houston. Here are the 5 Google Profile fixes that take about 30 minutes total.
20% use 'Auto glass shop' as their primary category — triggering windshield repair searches instead of tinting. The average description uses 417 of 750 characters. Top shops average 159 photos.
CPO (Co-Packaged Optics) testing is critical because the cost of failure is enormous. Once an optical engine is attached to the switch package, a defect can jeopardize the entire assembly rather than a replaceable module. The CPO test flow follows four sequential phases, each with distinct technical challenges, equipment requirements, and vendor ecosystems. (1/5)
Phase 1 — Wafer-Level Single-Die Test: The EIC and PIC are tested separately at the wafer level before bonding. The EIC is standard CMOS wafer sort (no new equipment). The PIC requires novel double-sided electro-optical probing — this is where all the new equipment spend goes. (2/5)
Phase 2 — Double Side Wafer-Level Test (EIC + PIC): After the EIC and PIC are bonded together (via hybrid bonding, wire bonding, or flip-chip), the combined wafer is tested as an integrated E/O unit before dicing. (3/5)
1/ Four years after Russia’s full-scale invasion, Ukraine has become a “steel porcupine” — making it impossible for Russia to digest.
As warfare becomes cheaper and more technological, Ukraine's advantages will grow.
🧵
As warfare becomes cheaper and more technological, Ukraine's advantages will grow.
🧵
2/ Many in the West thought Kyiv would fall in days or weeks in 2022.
That did not happen.
Ukraine survived by adapting fast and building a war effort around drones and other low-cost technologies.
That did not happen.
Ukraine survived by adapting fast and building a war effort around drones and other low-cost technologies.
3/ This war is not just about territory for Ukraine.
It is an existential fight for survival, which is why Kyiv keeps investing in its own defense industry instead of waiting for others to save it.
It is an existential fight for survival, which is why Kyiv keeps investing in its own defense industry instead of waiting for others to save it.
U.S. CBDC on a centralized Blockchain has been stated goal for a long time. No conspiracy theory. AI and the Bioeconomy
CBDC 🧵
MARCH 09, 2022 Executive Order on Ensuring Responsible Development of Digital Assets (Documents below were written to support this Executive Order)
“Section 1. Policy. Advances in digital and distributed ledger technology for financial services have led to dramatic growth in markets for digital assets, with profound implications for the protection of consumers, investors, and businesses, including data privacy and security; financial stability and systemic risk; crime; national security; the ability to exercise human rights; financial inclusion and equity; and energy demand and climate change. In November 2021, non‑state issued digital assets reached a combined market capitalization of $3 trillion, up from approximately $14 billion in early November 2016. Monetary authorities globally are also exploring, and in some cases introducing, central bank digital currencies (CBDCs).”
“We must take strong steps to reduce the risks that digital assets could pose to consumers, investors, and business protections; financial stability and financial system integrity; combating and preventing crime and illicit finance; national security; the ability to exercise human rights; financial inclusion and equity; and climate change and pollution.”
“Cybersecurity and market failures at major digital asset exchanges and trading platforms have resulted in billions of dollars in losses. The United States should ensure that safeguards are in place and promote the responsible development of digital assets to protect consumers, investors, and businesses; maintain privacy; and shield against arbitrary or unlawful surveillance, which can contribute to human rights abuses.”
Sec. 4. Policy and Actions Related to United States Central Bank Digital Currencies. (a) The policy of my Administration on a United States CBDC is as follows:
(i) Sovereign money is at the core of a well-functioning financial system, macroeconomic stabilization policies, and economic growth. My Administration places the highest urgency on research and development efforts into the potential design and deployment options of a United States CBDC.
CBDC 🧵
MARCH 09, 2022 Executive Order on Ensuring Responsible Development of Digital Assets (Documents below were written to support this Executive Order)
“Section 1. Policy. Advances in digital and distributed ledger technology for financial services have led to dramatic growth in markets for digital assets, with profound implications for the protection of consumers, investors, and businesses, including data privacy and security; financial stability and systemic risk; crime; national security; the ability to exercise human rights; financial inclusion and equity; and energy demand and climate change. In November 2021, non‑state issued digital assets reached a combined market capitalization of $3 trillion, up from approximately $14 billion in early November 2016. Monetary authorities globally are also exploring, and in some cases introducing, central bank digital currencies (CBDCs).”
“We must take strong steps to reduce the risks that digital assets could pose to consumers, investors, and business protections; financial stability and financial system integrity; combating and preventing crime and illicit finance; national security; the ability to exercise human rights; financial inclusion and equity; and climate change and pollution.”
“Cybersecurity and market failures at major digital asset exchanges and trading platforms have resulted in billions of dollars in losses. The United States should ensure that safeguards are in place and promote the responsible development of digital assets to protect consumers, investors, and businesses; maintain privacy; and shield against arbitrary or unlawful surveillance, which can contribute to human rights abuses.”
Sec. 4. Policy and Actions Related to United States Central Bank Digital Currencies. (a) The policy of my Administration on a United States CBDC is as follows:
(i) Sovereign money is at the core of a well-functioning financial system, macroeconomic stabilization policies, and economic growth. My Administration places the highest urgency on research and development efforts into the potential design and deployment options of a United States CBDC.
Part 2
September 2022 The Future of Money and Payments Report Pursuant to Section 4(b) of Executive Order 14067 home.treasury.gov/system/files/1…
“Environmental sustainability The United States has set overarching environmental priorities, including cutting U.S. greenhouse gas pollution by 50-52 percent by 2030 and transitioning to a net-zero emissions economy by 2050.112 A new payments system or improvements to existing payment systems should be compatible with these priorities and seek to minimize energy use, resources, greenhouse gas emissions, and other pollution, and improve environmental performance relative to the status quo of the existing payments system. Reflecting these priorities, forms of money and payment need to be environmentally sustainable. If based on a blockchain, a U.S. CBDC would likely use a permissioned blockchain, which consumes relatively less energy than a permissionless implementation, as the majority of the energy use from permissionless blockchains derives from the consensus mechanism.113 In addition, policymakers could require energy efficiency as a key tenet of the development of a U.S. CBDC technology. This technology could form the basis of environmentally sustainable technologies for other financial markets, promoting public welfare.” In part because they would not be based on a permissionless blockchain, instant payments do not raise the same questions of environmental sustainability and are likely to be consistent with the Administration’s climate goals. The proof-of-work consensus mechanism associated with certain blockchains uses more energy than some countries do.114 Therefore, stablecoins that rely on proof-of-work blockchains likely represent the least efficient option from a sustainability perspective. Although technologies are under development that could lessen energy use, a permissioned blockchain or instant payments would be more sustainable options with current technology.”
September 2022 The Future of Money and Payments Report Pursuant to Section 4(b) of Executive Order 14067 home.treasury.gov/system/files/1…
“Environmental sustainability The United States has set overarching environmental priorities, including cutting U.S. greenhouse gas pollution by 50-52 percent by 2030 and transitioning to a net-zero emissions economy by 2050.112 A new payments system or improvements to existing payment systems should be compatible with these priorities and seek to minimize energy use, resources, greenhouse gas emissions, and other pollution, and improve environmental performance relative to the status quo of the existing payments system. Reflecting these priorities, forms of money and payment need to be environmentally sustainable. If based on a blockchain, a U.S. CBDC would likely use a permissioned blockchain, which consumes relatively less energy than a permissionless implementation, as the majority of the energy use from permissionless blockchains derives from the consensus mechanism.113 In addition, policymakers could require energy efficiency as a key tenet of the development of a U.S. CBDC technology. This technology could form the basis of environmentally sustainable technologies for other financial markets, promoting public welfare.” In part because they would not be based on a permissionless blockchain, instant payments do not raise the same questions of environmental sustainability and are likely to be consistent with the Administration’s climate goals. The proof-of-work consensus mechanism associated with certain blockchains uses more energy than some countries do.114 Therefore, stablecoins that rely on proof-of-work blockchains likely represent the least efficient option from a sustainability perspective. Although technologies are under development that could lessen energy use, a permissioned blockchain or instant payments would be more sustainable options with current technology.”
Part 3
September 2022: White House Office of Science and Technology Policy, Climate and Energy Implications of Crypto-Assets in the United States (Referenced in document #7 Treasury) whitehouse.gov/wp-content/upl…
“At the same, the use of digital assets based on distributed ledger technology is expanding. Digital assets are a form of value, represented digitally. As an emerging technological innovation, digital assets have provided some benefits and value for some U.S. residents and businesses, and have the potential for future benefits with emerging uses. Crypto-assets are digital assets that are implemented using cryptographic techniques, and have a total current global market capitalization of nearly $1 trillion. However, some crypto-asset technologies currently require a considerable amount of electricity for asset generation, ownership, and exchange. Electricity usage from digital assets is contributing to GHG emissions, additional pollution, noise, and other local impacts, depending on markets, policies, and local electricity sources. Depending on the energy intensity of the technology used, crypto-assets could hinder broader efforts to achieve net-zero carbon pollution consistent with U.S. climate commitments and goals.”
Crypto-Assets Can Have Significant Environmental Impacts whitehouse.gov/ostp/news-upda…
Global electricity generation for the crypto-assets with the largest market capitalizations resulted in a combined 140 ± 30 million metric tons of carbon dioxide per year (Mt CO2/y), or about 0.3% of global annual greenhouse gas emissions. Crypto-asset activity in the United States is estimated to result in approximately 25 to 50 Mt CO2/y, which is 0.4% to 0.8% of total U.S. greenhouse gas emissions. This range of emissions is similar to emissions from diesel fuel used in railroads in the United States.
SEPTEMBER 12, 2022 Executive Order on Advancing Biotechnology and Biomanufacturing Innovation for a Sustainable, Safe, and Secure American Bioeconomy
Ties to Bio Surveillance, programming Biology like we do software, One Health GHSA SDGs
“Section 1. Policy. It is the policy of my Administration to coordinate a whole-of-government approach to advance biotechnology and biomanufacturing towards innovative solutions in health, climate change, energy, food security, agriculture, supply chain resilience, and national and economic security. Central to this policy and its outcomes are principles of equity, ethics, safety, and security that enable access to technologies, processes, and products in a manner that benefits all Americans and the global community and that maintains United States technological leadership and economic competitiveness.”
“The economic activity derived from biotechnology and biomanufacturing is referred to as “the bioeconomy.” The COVID-19 pandemic has demonstrated the vital role of biotechnology and biomanufacturing in developing and producing life-saving diagnostics, therapeutics, and vaccines that protect Americans and the world.”
“We need to develop genetic engineering technologies and techniques to be able to write circuitry for cells and predictably program biology in the same way in which we write software and program computers; unlock the power of biological data, including through computing tools and artificial intelligence; and advance the science of scale‑up production while reducing the obstacles for commercialization so that innovative technologies and products can reach markets faster.”
September 2022: White House Office of Science and Technology Policy, Climate and Energy Implications of Crypto-Assets in the United States (Referenced in document #7 Treasury) whitehouse.gov/wp-content/upl…
“At the same, the use of digital assets based on distributed ledger technology is expanding. Digital assets are a form of value, represented digitally. As an emerging technological innovation, digital assets have provided some benefits and value for some U.S. residents and businesses, and have the potential for future benefits with emerging uses. Crypto-assets are digital assets that are implemented using cryptographic techniques, and have a total current global market capitalization of nearly $1 trillion. However, some crypto-asset technologies currently require a considerable amount of electricity for asset generation, ownership, and exchange. Electricity usage from digital assets is contributing to GHG emissions, additional pollution, noise, and other local impacts, depending on markets, policies, and local electricity sources. Depending on the energy intensity of the technology used, crypto-assets could hinder broader efforts to achieve net-zero carbon pollution consistent with U.S. climate commitments and goals.”
Crypto-Assets Can Have Significant Environmental Impacts whitehouse.gov/ostp/news-upda…
Global electricity generation for the crypto-assets with the largest market capitalizations resulted in a combined 140 ± 30 million metric tons of carbon dioxide per year (Mt CO2/y), or about 0.3% of global annual greenhouse gas emissions. Crypto-asset activity in the United States is estimated to result in approximately 25 to 50 Mt CO2/y, which is 0.4% to 0.8% of total U.S. greenhouse gas emissions. This range of emissions is similar to emissions from diesel fuel used in railroads in the United States.
SEPTEMBER 12, 2022 Executive Order on Advancing Biotechnology and Biomanufacturing Innovation for a Sustainable, Safe, and Secure American Bioeconomy
Ties to Bio Surveillance, programming Biology like we do software, One Health GHSA SDGs
“Section 1. Policy. It is the policy of my Administration to coordinate a whole-of-government approach to advance biotechnology and biomanufacturing towards innovative solutions in health, climate change, energy, food security, agriculture, supply chain resilience, and national and economic security. Central to this policy and its outcomes are principles of equity, ethics, safety, and security that enable access to technologies, processes, and products in a manner that benefits all Americans and the global community and that maintains United States technological leadership and economic competitiveness.”
“The economic activity derived from biotechnology and biomanufacturing is referred to as “the bioeconomy.” The COVID-19 pandemic has demonstrated the vital role of biotechnology and biomanufacturing in developing and producing life-saving diagnostics, therapeutics, and vaccines that protect Americans and the world.”
“We need to develop genetic engineering technologies and techniques to be able to write circuitry for cells and predictably program biology in the same way in which we write software and program computers; unlock the power of biological data, including through computing tools and artificial intelligence; and advance the science of scale‑up production while reducing the obstacles for commercialization so that innovative technologies and products can reach markets faster.”
GLP-1 drugs are the ultimate validation of the techno-solutionist approach to society's most challenging problems.
The obesity crisis seemed liked it would just get worse and worse forever. Scolding from public health officials didn't work. Proposals to completely overhaul our food systems were dead on arrival.
Instead, we invented a weekly shot (based on Gila monster venom!) that fixes obesity directly.
And now, thanks to the economic incentives in our biomedical industry, we have follow-on drugs that will be cheaper, even more effective, and easier to administer (by taking a pill instead of a shot).
Policymakers should be focused on figuring out how we can get more breakthrough drugs like GLP-1s (and faster). They also should think hard about which slopulist ideas might inadvertently kill the goose that lays the golden eggs.
The obesity crisis seemed liked it would just get worse and worse forever. Scolding from public health officials didn't work. Proposals to completely overhaul our food systems were dead on arrival.
Instead, we invented a weekly shot (based on Gila monster venom!) that fixes obesity directly.
And now, thanks to the economic incentives in our biomedical industry, we have follow-on drugs that will be cheaper, even more effective, and easier to administer (by taking a pill instead of a shot).
Policymakers should be focused on figuring out how we can get more breakthrough drugs like GLP-1s (and faster). They also should think hard about which slopulist ideas might inadvertently kill the goose that lays the golden eggs.
I've always preferred the "techno-solutionist" label instead of "techno-optimist" since reading @jasoncrawford's piece: technologyreview.com/2021/07/13/102…
We can't just sit idly by and believe things will get better in the future because they have in the past (they might not!).
We have to proactively identify problems and engineer targeted solutions to fix them.
We can't just sit idly by and believe things will get better in the future because they have in the past (they might not!).
We have to proactively identify problems and engineer targeted solutions to fix them.
@jasoncrawford We launched the clinical trial abundance movement a year and a half ago because of this opportunity.
We could have so many breakthrough drugs if clinical trials were cheaper, better, and faster.
ifp.org/the-case-for-c…
We could have so many breakthrough drugs if clinical trials were cheaper, better, and faster.
ifp.org/the-case-for-c…
Hungary suspend of gas transit to Ukraine risks a direct breach of the EU-Ukraine Association Agreement. Specifically,Article 273 prohibits any measures that lead to the "interruption or reduction of transit"of energy goods. Budapest is using energy as a political lever. #OOTT
Beyond the AA,Hungary is bound by Article 7 of the Energy Charter Treaty, which mandates freedom of transit. By linking gas flows to oil transit disputes,Hungary violates non-discrimination principles and the DCFTA (Article 35), bans quantitative restrictions on trade #OOTT
Despite ultimatum,Ukraine’s energy position remains stable due to record storage and diversified routes through Poland and Slovakia.Kyiv is now prepared to trigger the Early Warning Mechanism under Annex XXVII to involve the European Commission in the dispute. 🛡️⚡️ #OOTT #Energy
🚨New research from WashU shows that diamond dust, long proposed as an ideal solar geoengineering (#SRM) material for #SAI, may lose much of its cooling potential when real-world chemistry & manufacturing constraints are taken into account.
DETAILS🧵1/11
DETAILS🧵1/11
2/ Solar geoengineering, particularly stratospheric aerosol injection (#SAI), seeks to mimic volcanic cooling by dispersing reflective particles into the upper atmosphere, reducing incoming solar radiation and temporarily offsetting warming.
3/ Sulfate aerosols (from volcano-like approaches) can cool the planet, but they come with risks: acid rain, ozone damage, and health impacts.
So scientists have been searching for safer alternatives like diamond.
agupubs.onlinelibrary.wiley.com/doi/10.1029/20…
So scientists have been searching for safer alternatives like diamond.
agupubs.onlinelibrary.wiley.com/doi/10.1029/20…
