Thread by @RajlabN

Tracking #SARSCoV2 #Lineages - Globally

Top lineages -#20DayTrends (#G20):

BQ.1.1 (18.9%)
XBB.1.5 (18.7%)👀^
CH.1.1 (5.3%)👀
BQ.1 (3.7%)
XBB.1 (2.7%)
BA.5.2.48 (2.3%)
XBF (1.7%)

^more sequences from USA in this period

Tracker: public.tableau.com/app/profile/ra…

Updated 02/02/2023

Granular details #Global #20DayTrends

This analysis includes all designated #SARSCoV2 sequences submitted to GISAID with sample collection dates on or after 01/12/2023

USA has submitted a lion's share of sequences with sample collection dates on or after 01/12/2023 ...followed by #Canada, #UnitedKingdom, #Austria, #Japan, #Denmark, #Germany, #France, #China, #Australia, #Italy

In Silico Immune escape and ACE2 receptor binding scores (relative to BA.2)*

Data is intended to prioritize select lineages to generate rapid laboratory experiments to gauge immune escape and ACE2 binding affinity.

[Credits in the legend]

* Only Spike RBD mutations considered

#SARSCoV2 lineages DS.1^^ (BN.1.3.1.1), XBB.1.5*, XBF, BN.1*, DN.1.1^^, XBB.6.1^^, XBB.1.9.1^^, CJ.1^^, CP.1.3^^, XBL^^, XBK^^ are in the zone of concern (red box) - Predicted to have high immune escape and tight ACE2 binding affinity!

DS.1* stands out!

^^ low sequence count

What to expect in the next few weeks?

github.com/neherlab/SARS-…

Excellent SARSCoV2 Variant report
H/T @richardneher, @CorneliusRoemer

Global variant landscape without sequences from USA (for context)

Top circulating lineages in #UnitedKingdom #20DayTrends

18% CH.1.1,
15.4% BQ.1.1,
11.6% XBB.1.5
7.6% CH.1.1.1
4% BQ.1.1.2
2.2% CH.1.1.2
2.1% XBF

public.tableau.com/app/profile/ra…