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David Sinclair, PhD Profile picture
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10 Jun 18, 6 tweets, 2 min read
It's #TonyAwards day! And that's got me thinking about all the science-themed musicals that I'm dying to see on Broadway...
"Little Animals," as told through the letters of Antonie van Leeuwenhoek as he tried to convince the Royal Society of London that he wasn’t completely crazy. Starring @TomHolland1996, naturally.
"Oh, Peas," the scandalous tale of the bishop who ordered Gregor Mendel’s to stop watching mice have sex. With @AndrewRannells in a monk frock!
"See? Elegans!" a rollicking nematode adventure, with @sfosternyc as Cynthia Kenyon.
“Snippets,” a transhumanist love story, with @AudraEqualityMc and @Lin_Manuel as star-crossed CRISPR scientists.
But seriously: Broadway has taken on some of the most challenging stories of our world, but science representation in musicals is still quite thin. I'd love to see that change!

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More from @davidasinclair

David Sinclair, PhD Profile picture
15 May
One third of homes have a cat. There are 600M globally. A study @NEJM confirms cats spread #coronavirus to each other & may spread it between family members. I’m concerned it could mix with a fatal cat coronavirus... 1/n
Some say “Well, the virus has not been proven to spread from cat to human.” As @StevenAustad has pointed out, this hasn’t been tested or disproven either. It is like saying in December 2019 that a virus in China hasn’t been proven to spread to the US. 2/n
Is no one but me concerned about viral genetic mixing & a new strain emerging from cats? Cats have their own #coronaviruses. They can cause one of the most fatal cat diseases known by destroying white blood cells (HIV-like). 3/n
Read 10 tweets
David Sinclair, PhD Profile picture
14 May
1/ Let me start by saying that this was a fantastic piece on vaccine development by @stuartathompson at @NYTimes.
2/ Having started a now public company that makes vaccines (thanks to my cofounder Darren Higgins and to @gatesfoundation), I can tell you many people don't appreciate just how long it takes to develop a drug.
3/ Vaccines often take longer. Of every drug that is picked to go into humans, less than 5% will ultimately be approved. Luckily, the outbreaks of SARS and MERS in 2004 and 2012 have given us a head start (SARS and SARS-CoV-2 are ~80 percent identical).
Read 7 tweets
David Sinclair, PhD Profile picture
14 May
Outlook for this decade: POOR
1. 85% of economic impact is caused by fear of the virus not by stay-at-home. 2. WHO says the virus may never leave, like HIV. If true, we are in serious trouble. 1/n
Let’s not ignore the likelihood that survivors “will be left with chronic kidney & heart problems”, something the pro-herd immunity folks don’t consider. If you think spending 17% of US GDP on healthcare is bad now...2/n
We have also seen that leadership matters. NZ & Australia stopped movement, enforced it & tested and traced asymptomatics. They couldn’t even buy a coffee & are now essentially covid-free. US & Britain waited, let people travel & didn’t test & trace. We see the consequences. 3/n
Read 6 tweets
David Sinclair, PhD Profile picture
11 May
Finally had time to carefully read the new preprint that claims to reverse the age of rats by 54%. I spoke to the first author & in this thread ask whether the results are believable and what if it is true? tinyurl.com/yapwdy87 1/n
The result is so literally incredible that even the first author, Prof. Steve Horvath, didn't believe it at first. I suggested he check if the rats were mixed up, but he assured me he checked their genomes. The rats weren't mixed up and the data is the data. 2/n
Being from a commercial operation called Nugenics (sounds like eugenics?) and calling the blood plasma fraction "Elixir" doesn't inspire confidence. But let's dig in...3/n
Read 24 tweets
David Sinclair, PhD Profile picture
10 May
The Festival of Dangerous Ideas live streaming now. Dr. @normanswan and I chat live at 10EST tonight, midday AEST. Free to all. festivalofdangerousideas.com ✌️ #fodi #aging #health
Will check if it’s recorded and report back.
Yep, I’ve confirmed it’s recorded and will be uploaded to YouTube. I will provide the links. Get some sleep 😴
Read 5 tweets
David Sinclair, PhD Profile picture
9 May
Important! Largest study yet on #Covid_19 fatality shows top risks:
1. Age, BY FAR the highest
2. Cancers of the blood
3. Male
4. Obesity
5. Diabetes
I will say it again: Aging is a disease & it is treatable. Yes, treatable. 1/n #healthcare tinyurl.com/yahsd3vq @bengoldacre
Striking finding: smoking makes little difference to #Covid_19 fatality, so it can’t explain bias in male deaths (What can? Hint: males age faster). 2/n
For smoking, error bar on the hazard ratio chart is close to zero, so smoking is probably not protective either, as some have speculated. tinyurl.com/y8l2qpom 3/n
Read 6 tweets

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