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@transmum1 @AshKSkeet 1/ Progesterone BP (the real stuff, as in Utrogestan, Cyclogest, Microgest, Prometrium, Progestan) is _essential_ for normal mammary & nipple development, & several other vital functions. Without it tissue is limited, & lumpy. But estrogen alone should precede combined therapy. 
@transmum1 @AshKSkeet 2/ That is because it it is E prevents gonadal activity, & redistributes fat, creating the fat pads on the chest which the mammary tissues requires to be able to grow into, & E causes P receptors to increase. P also limits excessive brain neurone branching E can cause, promotes…
@transmum1 @AshKSkeet 3/…production of lipids in the eyes & skin that prevent excessive dryness, prevents skin & nails becoming too thin, protects the essential mucous in the throat & airways, & is essential for regulation of myelination of nerves. It's metabolites protect from anxiety & depression.
@transmum1 @AshKSkeet 4/ It is as if both E & P, in varying balance, are needed to replace the equivalent effects in 🚺 of T alone in 🚹. This all in revered papers, but it is as if endocrinologists don't read. Many don't know any difference between Provera & Progesterone.
