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Franz Wiesbauer, MD MPH Profile picture
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Apr 17, 2020 • 6 tweets • 5 min read
THREAD: This is incredibly interesting and important. Harvard scientists found that air pollution can worsen death rats from COVID-19 four to five-fold. The paper is currently available as preprint: projects.iq.harvard.edu/files/covid-pm…

#Covid_19 #COVID19 #COVIDー19 #coronavirus
#SARSCoV2
2: Particulate matter < 2.5 μm in size also called PM2.5 was used to measure pollution: "...a county with PM2.5 levels of 15 μg/m3 (highly polluted) would have approximately 4.5 times higher COVID-19 death rate than a county with PM2.5 levels of 5 μg/m3 (low pollution)" Image
3: These are the PM2.5 trends for the USA until 2018 from epa.gov/air-trends/par… Image
4: Here's what the "Urban PM2.5 Atlas: Air Quality in European cities" has to say about air quality in Europe. Can you spot any outliers? I'd say Lombardy looks pretty bad.
ec.europa.eu/jrc/en/publica… Image
5: Thanks to @linseymarr for bringing this to my attention. Would be interested to hear what @mlipsitch @ScottGottliebMD @EricTopol @Don_Milton think about this?
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Franz Wiesbauer, MD MPH Profile picture
Jun 8, 2021
How a former Secretary of Defense will turn your kid into a genius problem-solver.

Thread 🧵 (1/11)
(2/11) In a 2002 news briefing about the lack of evidence linking [[Iraq]] to the supply of [[weapons of mass destruction]] to terrorist groups, former secretary of defense, [[Donald Rumsfeld]], coined a famous expression...
(3/11) Here's what he said: {{[[video]]: }}
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Franz Wiesbauer, MD MPH Profile picture
Apr 29, 2021
Nr 1 REASON Why most teams fail as they scale from a small group of 3-5 to a large company of >50 employees.

Secret from inside Amazon 🤫

THREAD (1/10)

Via @cbryar's book "Working Backwars" amazon.de/Working-Backwa… #Communication #Teams #Collaboration
(2/10) Large projects often have many dependencies

Managing dependencies btw teams requires coordination.

Coordination requires meetings, emails and other forms of communication.

Most organizations spend too much time coordinating and not enough time building.
(3/10) While the growth in employees (nodes in a network) is linear, the number of their possible lines of communication grows exponentially.

Potential connections in a network can be calculated as follows. source: the-vital-edge.com/what-is-networ…
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Franz Wiesbauer, MD MPH Profile picture
Jun 12, 2020
Great review in the @NEJM about epidemiologic models and their pitfalls. nejm.org/doi/full/10.10…

Pitfall #1: We don‘t know how many people have been truly infected. [1/4]
Pitfall #2: We remain uncertain about the extent of protective immunity, which greatly impacts the course of the epidemic.

Pitfall #3: What’s the extent of transmission and immunity among ppl with no or minimal symptoms (and children) [2/4]
Pitfall #4: It‘s very hard to measure and model contact rates between susceptible and infectious ppl nodt only under phys distancing but also in various reopening scenarios. [3/4]
Read 5 tweets
Franz Wiesbauer, MD MPH Profile picture
Jun 12, 2020
New meta-analyisis estimates: (1) proportion of truly asymptomatic #COVID19 cases and (2) proportion of #SARS_CoV_2 transmission from asymptomatic or pre-symptomatic individuals [1/3] medrxiv.org/content/10.110…
Overall, proportion of people who become infected with #SARS_CoV_2 and remain asymptomatic through the course of infection estimated to be 15% [2/3]
40-60% of #SARS_CoV_2 infections are the result of transmission from pre-symptomatic individuals. The contribution from asymptomatic individuals seems to be much smaller estimated at around 6% (but wide confidence intervals). [3/3]
Read 4 tweets
Franz Wiesbauer, MD MPH Profile picture
Jun 4, 2020
@JohnsHopkinsSPH measured the prevalence of serious psychological distress in 1468 adults aged 18 years or older in Apr 2020 & compared it with an identical measure from the 2018 National Health Interview Survey (NHIS). Thread (1/6)

jamanetwork.com/journals/jama/…
In April 2020, 13.6% of US adults reported symptoms of serious psychological distress, relative to 3.9% in 2018. That’s a 3.5-fold increase. (2/6)
Age: symptoms of psychological distress were highest among young adults aged 18 to 29 years. Distress decreased with increasing age in 2020. Previously, no effect of age on distress. (3/6)
Read 7 tweets
Franz Wiesbauer, MD MPH Profile picture
Jun 2, 2020
Short THREAD on chloroquine:

Mar 17: French doctor Didier Raoult et al publish a paper suggesting that hydroxychloroquine and antibiotic azithromycin could be effective against the disease. (1/6)

medrxiv.org/content/10.110… Image
Several public figures like @elonmusk jumped on the bandwagon promoting the drug based on results from basic research (not randomized trials, not even observational studies). (2/6) Image
And, obviously, the President also chimed in...(3/6) Image
Read 7 tweets

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