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A break from #SARSCoV2 to another challenge—very early diagnosis of #cancer. Just released @ScienceMagazine is a study of 10,000 women using a blood test (#genomics, proteins) and PET imaging w/ very high specificity of diagnosis (and low sensitivity)
science.sciencemag.org/content/early/…
As far as I know, this is the 1st prospective study to show very early diagnosis of #cancer in healthy people w/o symptoms and curative potential. For that it is groundbreaking. The authors acknowledge many limitations and the further work to be done
While a blood test + PET for very early #cancer detection in a large cohort healthy women was a highlight of the day, a hard look at the numbers are warranted. Especially false positives. @jocelynkaiser @ScienceMagazine reviews the caveats here sciencemag.org/news/2020/04/b…
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Eric Topol
@EricTopol
Best, up-to-date (May 2nd) graph to show the US plateau of ~2,000 deaths per day for the past 3 weeks, continuing
The US also has company with India, Brazil and Russia as the only major countries not improving.
Besides the US, the hardest hit ones (UK, France Spain, Italy) are all, fortunately, on the descent.
4 hard-hit states now showing reduction of hospitalized patients, which is very encouraging after all what they have been through
Read 5 tweets
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Eric Topol
@EricTopol
There were 2 important #COVID19 tracing reports this week:
China 391 cases, 1,286 contacts
Taiwan 1st 100 cases, 2,761 contacts
thelancet.com/journals/lanin… @TheLancetInfDis
jamanetwork.com/journals/jamai… @JAMAInternalMed
What can we learn from them? 1/x
While the median case incubation period was 4-5 days in both studies, there was a considerable range 2/x
"Attack rates were similar across all age categories of
infected contacts"
"Notably, the rate of infection in children younger than 10 years (7·4%) was similar to the population
average (6·6%)." 3/x
Read 5 tweets
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Eric Topol
@EricTopol
Another significant advance on the structural biology front for #SARSCoV2 today: cryo-EM for its polymerase (RdRp) complex along w/ that of remdesivir w/ RNA bound RdRp, the mechanism for its inhibition of replication
@ScienceMagazine science.sciencemag.org/content/early/… via @hholdenthorp
This is the 6th structural biology (SB) #SARSCoV2 (virus & antibody)paper @ScienceMagazine in < 2 months. Elucidation of these structures are pivotal to smart design of a drug, monoclonal Ab & vaccine, no less understanding of the 1 drug w/ efficacy so far.
SB is rockin' it!
You can say that again:
"We do know the cause of COVID-19. Down to the atoms."
—@hholdenthorp
The prior 5 #SARSCoV2 structural biology papers
@ScienceMagazine: spike protein, ACE2 receptor, main viral protease, an antibody, & its polymerase
blogs.sciencemag.org/editors-blog/2…
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