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(1) The seroprevalence among children and young adults in the Geneva study is really a bit puzzling. It's counter to what many others have described.



#COVID19 #SARSCoV2
(2) Zhang et al have shown that kids are less likely to get it.

science.sciencemag.org/content/early/…
(3) Lavezzo et al showed that in Vo, Italy, kids were less likely to get it.

medrxiv.org/content/10.110…
(4) Gudbjartsson et al showed that in Iceland, kids were less likely to get it.

nejm.org/doi/full/10.10…
(5) One potential problem with the Geneva data: who takes their kids to a doctor's appointment during a pandemic to have their bloods drawn? Maybe if kids were sick shortly before and parents wanted to know if they had "it"? Would add a potential bias.
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Franz Wiesbauer
@medmastery
1/n: Something that became quite clear to me after reading @JustinLessler et al's Lancet Inf. Dis. paper: if contact tracing should work, we will need to isolate contacts before PCR turns positive.

#COVIDー19 #SARS_COV_2

thelancet.com/journals/lanin…
2/n: Patients who were identified based on symptoms were diagnosed 4.6 days after symptom onset, whereas patients who were identified through contact tracing had a positive PCR test 2.9 days after symptom onset.
3/n: As we've learned from @gmleunghku et al., most infections have already occurred at 4.6 days and 2.9 days after symptom onset. Infectiousness is marked yellow in the attached images.

nature.com/articles/s4159…
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Franz Wiesbauer
@medmastery
1/n New #covid19 contact tracing study from Taiwan. Key findings:

A. Overall secondary attack rate was 18 of 2761, or 0.7%. Family contacts (household and non-household) clearly at increased risk.

jamanetwork.com/journals/jamai…
2/n:

B: No transmissions occurred in people who had contact with index case after day 6 following symptom onset.
3/n:

C: Transmission risk was higher when index case was severely ill. No transmissions occurred in asymptomatic cases.
Read 8 tweets
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Franz Wiesbauer
@medmastery
THREAD: This is incredibly interesting and important. Harvard scientists found that air pollution can worsen death rats from COVID-19 four to five-fold. The paper is currently available as preprint: projects.iq.harvard.edu/files/covid-pm…

#Covid_19 #COVID19 #COVIDー19 #coronavirus
#SARSCoV2
2: Particulate matter < 2.5 μm in size also called PM2.5 was used to measure pollution: "...a county with PM2.5 levels of 15 μg/m3 (highly polluted) would have approximately 4.5 times higher COVID-19 death rate than a county with PM2.5 levels of 5 μg/m3 (low pollution)" Image
3: These are the PM2.5 trends for the USA until 2018 from epa.gov/air-trends/par… Image
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