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Audrey Odom John MD PhD Profile picture
@odomjohnlab
Jul 19, 2020 • 31 tweets • 19 min read • Read on X
Day 1 of #idsaracialequitychallenge:
@NPR Shortwave Podcast on understanding unconscious bias:
npr.org/2020/07/14/891…
Day 2 of #IDSARacialEquityChallenge. Today, I’m borrowing these great podcast recs:



@IDSAInfo @PIDSociety #dothework https://t.co/SgPhfwULci
Day 3 of #IDSARacialEquityChallenge.

With fellowship interview season coming up, time to look in the mirror and retake the Harvard Implicit Association Test. Takes <10 min, and IMHO should be required for all academic selection committees:

implicit.harvard.edu/implicit/selec…
D4 #IDSARacialEquityChallenge

Today, I’m thinking about our medical trainees. Powerful essay by @ChristleNwora-

aamc.org/news-insights/…
D5 #IDSARacialEquityChallenge

Still thinking about our trainees and applicants, and how admissions committees talk about candidates with "grit" or "distance traveled" -

D6 #IDSARacialEquityChallenge

Today, a 5 mile run in the rain - while listening to this powerful and personal IDSA podcast episode on racial inequities and #COVID-19:

D7 #ISDARacialEquityChallenge

Today I'm reading and sharing this editorial @ScienceMagazine on systemic racism in science:

D8 #IDSARacialEquityChallenge, part 1

This one is hard, personal, and will take some time to process. I spent some time today confronting the history slave ownership in my own family.

Should this be relevant to you, some resources here: archives.gov/files/calendar…
D8 #IDSARacialEquityChallenge/2

From the 1850 US Census (Slave Schedule), meet Samuel Odom, who enslaved 8 people, mostly children (ages 30, 25, 11, 9, 7, 5, 3, and a baby). 💔 Image
D8 #IDSARacialEquityChallenge/3

I believe this is the same Samuel Odom, in an overtly white supremacist letter back home during the Civil War

I'm going to need to sit with this a bit.

digital.tcl.sc.edu/u?/civilwar,18…
D9 #idsaracialequitychallenge

Today, back to thinking more about efforts to increase URiM faculty in medical sub-specialities, like Peds ID:

D10 #IDSARacialEquityChallenge

Sharing this essay from my former @DukeMedSchool classmate, Damon Tweedy, on racism in medicine:

nytimes.com/2020/07/27/opi…
D11 #IDSARacialEquityChallenge

Today, facing the institutional racism in academia, with these words from the Dr. Bumpus, Chair of Pharmacology and Molecular Sciences at Johns Hopkins:

D12 #IDSARacialEquityChallenge

Proud to share this statement from @AmerAcadPeds apologizing for the “shameful gauntlet to membership” for its first Black members:

D13 #IDSARacialEquityChallenge

Honoring John Lewis today - sharing his final must-read call to action again:

D13, part 2
And more on his life story from this NYT podcast:

nytimes.com/2020/07/20/pod…?
D14 #IDSARacialEquityChallenge

5. You’re not willing to sacrifice anything

forbes.com/sites/danabrow…
D15 #IDSARacialEquityChallenge

Really thinking today about what it means that Black women in Philly are so much more likely to get infected with SARS-CoV2 -

D16 #IDSARacialEquityChallenge

Today, sharing this meaty article (recommended by IDSA) on
structural racism and health inequities:

ncbi.nlm.nih.gov/pmc/articles/P…
D17 #IDSARacialEquityChallenge

Registering today for this incredible webinar (Oct. 1) on slavery and its legacy in NC, featuring a number of institutions near my home town (h/t @rejoicePhD):

D18 #IDSARacialEquityChallenge

Sharing yet more evidence - this time in pediatrics - of the racial and ethnic disparities in #SARSCoV2 infection:

D19 #IDSARacialEquityChallenge

Terrific @IDSA @IDSAMedEdCOP thread that includes many actions programs are taking to improve diversity and inclusion in ID:

D20 #IDSARacialEquityChallenge

Today I'd like to recommend this terrific but super-quick (2 min!) video from the BBC explaining the concept of white privilege (h/t @500womensci):

Also I could listen to this accent all day...

bbc.co.uk/bitesize/artic…
D21&22 #IDSARacialEquityChallenge

2 updates to finish the weekend:

1) Racial bias...in pulse oximetry:
bostonreview.net/science-nature…

2) “I didn’t tell you” – a poem written and spoken by Norma Johnson (h/t: @taliaswarz):
D24 #IDSARacialEquityChallenge

D24, part 2 #IDSARacialEquityChallenge

And a special call to pediatricians, because the excess mortality in minority communities is not limited to adults. Here's St. Louis data from 2012:

@PIDSociety #tweetiatrician
source: bit.ly/3ixqCoQ Image
D25 #IDSARacialEquityChallenge

More devastating data on racial disparities in mortality -

D26 #IDSARacialEquityChallenge

Words of wisdom:

D27 #IDSARacialEquityChallenge

Advice for those working on being an ally:

via @Forbes

forbes.com/sites/amberjoh…
D28 #IDSARacialEquityChallenge

Today, sharing this important commentary on eliminating structural racism in medicine via @JAMA_current

The @IDSAInfo @pids challenge is over but the work goes on ...

ja.ma/3iRSR1L
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More from @odomjohnlab

Audrey Odom John MD PhD Profile picture
Aug 2, 2020
Oh, look at these VERY GOOD DOGS! 🐶

Covid-sniffing puppers from PennVet @pennvet @PennVetWDC, happily working hard on our pediatric SARS-CoV2-infected samples! @CHOP_ID @CHOP_Research

nbcnews.com/nightly-news/v… Image
The whole video is just adorable - look at their tails go! (And the data is looking good, too)

nbcnews.com/nightly-news/v…
More on our study:
Read 5 tweets
Audrey Odom John MD PhD Profile picture
Jun 11, 2020
So excited to share some new work @PLOSPathogens from our group – on zoonotic staphylococci!

So, how’d we get from #malaria parasites to pathogens of puppies 🐶?

🧵

journals.plos.org/plospathogens/…
We’ve been collaborating w/Cindy Dowd at GWU (@GWtweets) making new antimalarials called MEPicides = cool prodrugs that target the DXR enzyme of the MEP pathway -- an essential biosynthetic pathway that humans and other mammals just don’t have/2

see:
nature.com/articles/s4159…
Turns out, malaria parasites aren’t the only bugs with the MEP pathway. We were totally inspired by Dan Beiting @hostmicrobe @pennvet – they found that staphylococci have either the mevalonate pathway (like people) or the MEP pathway (like parasites)/3

msphere.asm.org/content/1/5/e0…
Read 8 tweets
Audrey Odom John MD PhD Profile picture
Nov 27, 2019
#IDTwitter, a clinical pearl from d2 @CHOP_ID

Retropharyngeal abscess (RPA) is increasing in incidence (data from 2000 - 2012).

How likely is MRSA? Do you need to empirically cover? /1

academic.oup.com/jpids/article/…
@CHOP_ID To guide us, fortunately we have really nice data - from our own institution (from otolaryngologist Lisa Elden @CHOP_Research)!

A consecutive case series review of 178 kids with deep space neck infections:

…s-sagepub-com.proxy.library.upenn.edu/doi/full/10.11…

/2
@CHOP_ID @CHOP_Research We consider most infections polymicrobial, even though only 6.7% actually grew >1 organism. Common bugs in kids with surgical cultures?

☑️S. aureus (MSSA and MRSA)
☑️Group A strep
☑️other resp/oral colonizers (Hflu/S. milleri)

/3
Read 5 tweets
Audrey Odom John MD PhD Profile picture
Nov 26, 2019
THREAD

A little parasitology #MedEd inspired by d1 @CHOP_ID:

Diarrhea after contact with baby cows? Think #cryptosporidiosis! 💩+ 🐄 = #crypto

The other big exposure risk? Recreational water, especially pools and lakes 🏊‍♂️

cdc.gov/mmwr/volumes/6…

/1 Image
@CHOP_ID Calf exposure is such a big risk b/c calves are very likely to have #crypto. My favorite outbreak is this 2013 overturned cattle truck carrying 100s of calves. RR for diarrhea 3.0 in first responders who "carried calves":

cdc.gov/mmwr/preview/m…

/2
@CHOP_ID T-cell immunity is important to #crypto control - think uncontrolled HIV and cyclosporin inhibitors (tacro, CsA).

First key to management - restore immune function.

Antiparasitic treatment with nitazoxanide also helpful - but often not enough if IC

cdc.gov/parasites/cryp…
Read 7 tweets
Audrey Odom John MD PhD Profile picture
Nov 15, 2019
Let me tell you about our newest preprint – a story of heat shock and prenylation in Plasmodium falciparum!
biorxiv.org/content/10.110…

[Thread]
Most people with malaria get fever - how do malaria parasites survive that stress? /1
First of all, P. falciparum has a ton of heat shock proteins. In particular the DnaJ/Hsp40 family is very expanded – there are 49 Hsp40 family members in P. falciparum!! /2

Reviewed here: mdpi.com/2218-273X/9/7/…
We have previously found that one of these Hsp40s in Plasmodium is farnesylated – that is, modified by a 15-carbon isoprenyl group. We call it HSP40 and it is the canonical Hsp40 in malaria parasites. /3

more on the "prenylome" of malaria parasites: nature.com/articles/srep3…
Read 5 tweets
Audrey Odom John MD PhD Profile picture
Jul 18, 2018
New article on the "leaky pipeline" of #WomeninSTEM. Once female faculty get their first big grant, they tend to stay in science - yay! But...[thread]
pnas.org/content/early/…
Senior author Greenberg is quoted in @nature: "[Women] should realize that, sure, it is not easy in academia, but they are not going to have any more difficulty than men once they get their first grant.”
nature.com/articles/d4158…
Given the percentages of women in leadership positions, in named professorships, and even full professors at many institutions, this seems a surprising conclusion. Our own institution has had equal # of women medical trainees for >15 yrs - not reflected in our leaders.
Read 4 tweets

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