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#Cryptococcal Infection in #Hematologic #Malignancies and Hematopoietic Stem Cell Transplantation
Here we review crypto with attention to its background, epi, risk factors, presentations, diagnosis, treatment, & prevention in hematologic malignancies
pubmed.ncbi.nlm.nih.gov/32740974/
#Cryptococcal Infection in #Hematologic #Malignancies and Hematopoietic Stem Cell Transplantation
Here we review crypto with attention to its background, epi, risk factors, presentations, diagnosis, treatment, & prevention in hematologic malignancies
pubmed.ncbi.nlm.nih.gov/32740974/
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At baseline, even prior to the start of immunosuppression, newly diagnosed patients with heme malignancies have cellular & humoral immune deficits with functional and absolute defects in granulocyte and lymphocyte function
that place patients at increased risk for infections
At baseline, even prior to the start of immunosuppression, newly diagnosed patients with heme malignancies have cellular & humoral immune deficits with functional and absolute defects in granulocyte and lymphocyte function
that place patients at increased risk for infections
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Below is how crypto comes in from the environment. Note the very cool "Trojan horse" mechanism to get into the CNS!
Below is how crypto comes in from the environment. Note the very cool "Trojan horse" mechanism to get into the CNS!
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Below is a table of Risk Factors for crypto, both heme and non-heme factors
Below is a table of Risk Factors for crypto, both heme and non-heme factors
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India ink is traditionally used for CSF (A)
Sputum & BAL are best assessed with calcofluor white staining (B)
Mucicarmin (C) and alcian blue stain will highlight the polysaccharide capsule
Fontana-masson stain can highlight its melanin (D)
India ink is traditionally used for CSF (A)
Sputum & BAL are best assessed with calcofluor white staining (B)
Mucicarmin (C) and alcian blue stain will highlight the polysaccharide capsule
Fontana-masson stain can highlight its melanin (D)
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Here is a table discussing antifungal therapy for crypto
For some patients with baseline cytopenias, it may be difficult to give flucytosine, in which case you may need to extend the ambisome duration to 4-6 weeks
Here is a table discussing antifungal therapy for crypto
For some patients with baseline cytopenias, it may be difficult to give flucytosine, in which case you may need to extend the ambisome duration to 4-6 weeks
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The review has other details with respect to epidemiology, clinical presentation, other treatment modalities, and prevention. Thank you for taking a look!
The review has other details with respect to epidemiology, clinical presentation, other treatment modalities, and prevention. Thank you for taking a look!
