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Subhasree Ray

20 Oct, 13 tweets, 7 min read

Role of Zinc (Zn) during #COVID19: Probably The 2nd most important nutrient after #VitaminD. Zn is a must with antivirals in standard COVID care.

1. A study from Spain with 249 pts reported a zinc deficiency increased the risk of death by 2.3 times.
medicalxpress.com/news/2020-09-z…

2. A study from Japan reported Zn deficiency in 14% pts who remained mild to moderate & 84% among them later progressed into severe COVID 19.
ijidonline.com/article/S1201-…

3. A study from India with 47 COVID 19 pts & 45 healthy controls revealed that the COVID 19 pts had significantly lower Zn level & developed more complications (70.4% Vs. 30.0%, p=0.009). Zn def. pts also had a prolonged hospital stay. (7.9 d Vs 5.7 d).
ijidonline.com/article/S1201-…

4. A study involving 962 pts reported a 44% reduction in death among 441 patients who received #hydroxycholoroquine, Azithromycin & Zn than 521 pts who received just HCQ and Az.
microbiologyresearch.org/content/journa…

5. Zn as a Virus blocker: Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture.
journals.plos.org/plospathogens/…

6. The most common symptoms of COVID-19 are impaired smell & taste, fever, cough, sore throat, general weakness, pain as aching limbs, runny nose, and in some cases diarrhea. All these symptoms are associated with altered zinc homeostasis.
ncbi.nlm.nih.gov/pmc/articles/P…

7. An ex-vivo model of chronic obstructive pulmonary disease (COPD) showed that decreasing zinc levels raised the leakage of the epithelium of the respiratory tract.
pubmed.ncbi.nlm.nih.gov/29255357/

8. A review article titles "Zinc as a Gatekeeper of Immune Function" discusses underlying mechanisms responsible for the regulation of cellular signaling by alterations in zinc homeostasis.
ncbi.nlm.nih.gov/pmc/articles/P…

9. Zinc deficiency in an experimental human model caused an imbalance between Th1 and Th2 functions.
academic.oup.com/jid/article/18…

10. The World Health Organization (WHO) in 2002 assumes that at least one-third of the world population is affected by zinc deficiency. The fact that zinc deficiency is responsible for 16% of all deep respiratory infections worldwide.
pubmed.ncbi.nlm.nih.gov/12691085/

11. A recent review ranked zinc as the top three most vital nutrients for immunological health, alongside vitamins C and D.
ncbi.nlm.nih.gov/pmc/articles/P…

12. Broad Functions of Zinc:

- Immune cells’ activities
- Production of antibodies
- Recruitment of immune cells to the infection site
- Reduction of inflammation and oxidative stress
- Maintenance of the integrity of the organs

Key: Zn + Antiviral + Vitamin C + Vitamin D

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More from @DrSubhasree

Subhasree Ray

@DrSubhasree

19 Oct

@Bharat_J25

TRENDSETTER: In a scientific move, Vemulapalem Anganwadi, Gudur Mandal, #Nellore, Andhra Pradesh is providing 'Nandini Suraksha' milk & eggs to the kids. This milk is homogenized & fortified with Vitamin A & Vitamin D. Thanks @Bharat_J25 for sharing these. @ysjagan

@xpressandhra

Kudos to the Anganwadi workers for understanding the importance of Vitamin A and D in a child's growth and development. Requesting relevant media houses to report this intelligent work. @xpressandhra @ThePrintIndia

@CollectorGuntr

Just came to know another Anganwadi in the Guntur district providing the same milk. @CollectorGuntr

https://twitter.com/Abhiramchiru/status/1318170138802225153?s=19

Read 4 tweets

Subhasree Ray

@DrSubhasree

18 Oct

What do we know about Vitamin C and #COVID19 so far?

The role of #VitaminC goes beyond immunity-boosting & the micronutrient at high dose is crucial to prevent severity.

Making a case with 14 studies, postulating Vitamin C to be an integral part of COVID treatment.

Direct Association:

1. August 2020 case study in a 74 years old COVID 19 patient with acute respiratory distress syndrome treated with oral vitamin C 1 g twice a day along with antivirals was able to be taken off mechanical ventilation within 5 days.
ncbi.nlm.nih.gov/pmc/articles/P…

2. A single-center observational study identified a total of 17 patients who received IV vitamin C for COVID-19 & noted a significant decrease in inflammatory markers, including ferritin and D-dimer, and a trend to decreasing FiO2 requirements.
covid19.elsevierpure.com/en/publication…

Read 17 tweets

Subhasree Ray

@DrSubhasree

16 Oct

@MamataOfficial

On #WorldFoodDay2020, #WestBengal's Three Distinct Schemes:

1. 'Didir Rannaghar (Mamata's Kitchen):

a. In a kind gesture, WB CM @MamataOfficial is offering meals at just Rs. 5 to all migrant workers from 11 am to 3 pm with a new menu every day. (1/4)
sarkariyojana.com/mamata-kitchen…

b. What else is included in 'Didir Rannaghar'?

- New clothes are also donated to the poor keeping the auspicious occasion of Durga Puja in mind.

- As per the guideline, hygiene and Social distancing are maintained with special attention. (2/4)

2. Khadya Sathi scheme:

Incepted on January 27, 2016, this scheme aimed to provide 90% of the state population with rice & wheat at Rs. 2/kg. According to the latest report, the state has ensured food security of 90% of people across the state. (3/4)
deccanherald.com/national/east-…

Read 4 tweets

Subhasree Ray

@DrSubhasree

13 Oct

Vitamin K & #COVID19:

Thrombosis is a major manifestation of COVID-19 that contributes to poor outcomes. Vitamin K plays a crucial role in the activation of both pro & anti-clotting factors in the liver, prevent elastic fiber degradation, possibly prevent comorbidities. THREAD

1. Matrix Gla protein (MGP) is a vitamin K-dependent inhibitor of soft tissue calcification & elastic fiber degradation. Severe extrahepatic vitamin K insufficiency is recently demonstrated in COVID-19 pts, w/high inactive MGP levels correlating w/elastic fiber degradation rates.

MGP Protects against elastic fiber degradation that provides deformability to the lungs & arteries, which facilitates respiration & circulation. The balance between elastic fiber degradation & repair is of vital importance in cardiac & pulmonary health.
nature.com/articles/38607…

Read 13 tweets

Subhasree Ray

@DrSubhasree

11 Oct

@ArvindKejriwal

Unique Initiative: As #COVID19 spreads to rural pockets of Delhi, Govt. to create task force called 'Nigrani Samiti' for effective containment of the virus and enforce COVID appropriate behaviour among the residents. (1/4) @ArvindKejriwal
google.com/amp/s/indianex…

Delhi Disaster Management Authority stated every task force will be made up of a patwari, a local civil defence warden and two members of the village committee to assess the ground situation and submit its report regularly to the SDM/tehsildar concerned. (2/4)

The teams will create awareness through posters, wall paintings and distribution of pamphlets. They will have to ensure regular spraying of disinfectants like sodium hypochlorite solution in public places like chaupals and akhadas. (3/4)

Read 4 tweets

Subhasree Ray

@DrSubhasree

8 Oct

Thread: Antioxidant & Anti-inflammatory phytonutrients could target the pathogenesis of #COVID19.

Do phytonutrients have the capacity to enhance immunity? Existing literature and evidence to support the hypotheses for 4 phytonutrients & 2 micronutrients.
frontiersin.org/articles/10.33…

1. Curcumin:

a. Inhibits the production of pro-inflammatory cytokines (IL-6 and TNF- α) in lipopolysaccharide (LPS)-stimulated BV2 microglial cells and IL- 1β and IL-6 in TNF-α treated HaCaT cells via inhibiting the NF-κB and MAPK signaling pathways.
pubmed.ncbi.nlm.nih.gov/17883952/

b. Curcumin exerts an antiviral effect on a broad range of viruses including influenza virus, adenovirus, hepatitis, human papillomavirus (HPV), human immunodeficiency virus (HIV), herpes simplex virus−2 (HSV-2), and Zika viruses.
ncbi.nlm.nih.gov/pmc/articles/P…