Facial motor nucleus is in the pontine tegmentum; axons loop dorsally around the abducens nucleus, then course anterolaterally, exiting the brainstem at the CPA.
2/11
The nervus intermedius (NI) is composed of preganglionic parasympathetic fibers w/cell bodies in the sup salivatory nucleus, taste fibers w/cell bodies in the nucleus solitarius, and somatic sensory input from EAC/external ear, w/cell bodies in the spinal nucleus of CNV.
3/11
Although NI and the motor components of CN7 are anatomically separate, they are generally not distinguished on imaging of the IAC.
4/11
Facial nerve is separated into 4 intratemporal segments (intracanalicular, labyrinthine, tympanic, mastoid). Cisternal is from the CPA to the internal auditory meatus. Intracanalicular within the IAC. Labarynthine is from the fundus of the IAC to the geniculate ganglion.
5/11
The greater superficial petrosal nerve (GSPN) arises from geniculate ganglion w/preganglionic parasymp fibers (and some taste/sensation) along floor of middle cranial fossa, through pterygoid canal, to pterygopalatine fossa➡️lacrimal gland(TOTD #1) (
The tympanic segment starts at the sharp turn of the geniculate ganglion and runs horizontally/posterolaterally along the medial margin of the middle ear. (There are no branches of the tympanic segment).
7/11
At the post middle ear, the mastoid segment begins➡️turns inferiorly through the facial canal in the mastoid, giving off 3 branches: nerve of stapedius, chorda tympani, and sensory auricular branch.
8/11
The chorda tympani includes taste fibers to the ant 2/3 of the tongue, as well as preganglionic parasympathetic fibers which extend to the submandibular ganglion. The ch tymp traverses the middle ear and eventually joins with the lingual nerve (CNV) on its way to the tongue
9/11
CN7 exits bony facial canal through stylomastoid foramen➡️gives off 3 motor branches: post auricular, digastric, stylohyoid. Traverses parotid gland, divides into 5 branches: temporal, zygomatic, buccal, marginal mandibular, cervical (mnemonic: To Zanzibar By Motor Car).
10/11
Relevant path: Bell’s palsy (may be HSV reactiv in geniculate ganglion); variable effects on CN7: facial palsy, hyperacusis (stapedius), pain at jaw/ear (sensory auricular), loss of taste (ch tymp), changes in tear (GSPN) and saliva production (ch tymp) #radiopaedia case
11/11
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2/5...The STN is functionally a node within the basal ganglia (BG) INDIRECT LOOP. STN contains excitatory glutaminergic neurons➞output to the GABA neurons of GPi, which in turn have inhibitory effect on thalamic outputs to the motor cortex.
3/5...Loss of nigrostriatal input in Parkinsons Dz➞increased inhibitory output from GPi➞decreased thalamic stimulation of the motor cortex (through both direct and indirect loop circuits). Makes sense that DBS treatments were initially directed at disrupting activity in GPi.
2/6...Meckel’s cave (MC) is open to the subarachnoid space at its posterior margin (and is therefore filled with CSF). The trigeminal (Gasserion) ganglion lives in MC. Superiomedial to MC (and sharing a dural border), is the cavernous sinus. #radres#neurorad
3/6...Coursing anteriorly, the V1 and V2 branches of CNV exit MC to travel within the lateral wall of the cavernous sinus. V3 courses inferiorly to exit the middle cranial fossa through foramen ovale, without involving the cavernous sinus.
2/8..The HC: complex structure of limbic system; encodes memories from short->long term (also involved in pattern recognition,memory encoding & association, working memory,spatial nav, emotional behavior,awareness of conscious knowledge). Am I missing anything neuroscientists?
3/8...Anatomically: the HC is made of the cornu ammonis (CA) and dentate gyrus (DG); hippocampal formation also includes the subiculum and entorhinal cortex (EC). Can also be divided into head/body/tail. Supplied primarily by the PCA, and variably by anterior choroidal artery.
2/7...CN 3,6,V1 travel between two dural layers in the lateral wall of the CS. V2 often travels in the the inferolateral wall of the CS (sometimes inferior to the CS). Cranial nerve 6 floats freely in the CS (why CS pathology often selectively affects CN6).
3/7...Note that: postganglionic sympathetic inputs to the orbit (originating from the sup cervical ganglion) ascend with the ICA, branch off the ICA in the CS, and then join branches of CN3 (to sup tarsal muscle) and V1 (pupillary dilation).
ICA segments: C1 (cervical) becomes C2 (petrous) in the carotid canal of the petrous bone. Becomes C3 (lacerum) as it exits the carotid canal above the foramen lacerum. Becomes C4 (cavernous segment above the petrolingual ligament through the cavernous sinus.
...C5 (clinoid) above proximal to the distal dural ring. C6 (ophthalmic) is truly intracranial. C7 (communicating) distal to the Pcomm. Alternative segmentation schemes include C1-C4 (cervical, petrous, cavernous, supraclinoid/terminal)
The AC runs across the midline in front of the anterior columns of the fornix, behind the basal forebrain and beneath the anterior limb internal capsule and basal ganglia, surrounded by the bed nucleus of the stria terminalis.
The AC connects areas of the bilateral temporal poles and orbitofrontal cortex. Function is not entirely understood but it is thought to be important in the olfactory pathway and pain sensation, among other things.