I have had so many calls and messages about the fall in #AVCT @avacta's share price over recent weeks.

Let me be very clear: I am entirely unconcerned by this fall.

As the below Tweet shows, I had a long-term target of ~£20 BEFORE Avacta announced its #COVID19 workstreams. 1/n
The issue is - as is becoming more and more often the case in the world of micro-caps - people are buying companies like #AVCT without having first decided if it is a trade or an investment position.

I cover the importance of this distinction in my profile picture. 2/n
I myself am a trader, professionally, and actually hold very few long term investments. The volatility and lack of quality, accessible research renders AIM an excellent trading ground.

But @avacta #AVCT is an investment. In the next few weeks, it'll be submitting... 3/n
...its CTA for the pro-dox trial, and top line data for that should come in July/August next year.

If anyone can tell me more important clinical data for the welfare of mankind - to have ever been received by an AIM listed company - I am all ears.

Even though it's just... 4/n
...Phase I, it is easy to appreciate how positive data would demand a valuation of multiples of #AVCT @avacta's current mkt cap. Especially if it is listed on NASDAQ by then - which seems a reasonable assumption, given the recent US broker appointment.

Over the next 7-8...5/n
...months, until that top line data arrives, #AVCT will be selling #COVID19 diagnostics products in massive quantities, in my view.

The market seems to have forgotten that Adeptrix is already selling the #COVID19 BAMS test, as RUO, in conjunction with MS specialist Bruker. 6/n
Would these two really be marketing the BAMS test to customers, were it not already proven to be highly accurate?

These sales are generating revs for #AVCT right now.

Re: the critical product, the LFT: the delay, and thus the missed rev, has been the chief cause of dismay...7/n
...for private investors. I am as frustrated as anyone that it has taken this long for @avacta and @bbi_solutions to complete the TT. Yet we continue to see other rapid antigen tests being ripped into by the science community for their poor quality. So it seems #AVCT is... 8/n
...perhaps doing the right thing, by aiming for perfection, prior to launching its LFT.

The argument that angry PIs are proffering is: by striving for perfection, #AVCT has already missed out on hundreds of millions of pounds in revenue this year.

That is true. But the... 9/n
...other side to the argument is that the market for #COVID19 rapid tests will be around for years, regardless of successful vaccines coming online.

Heathrow's CEO seems to agree with this view of #AVCT's Alastair Smith, and not with angry PIs: 10/n

bloomberg.com/news/videos/20…
Accordingly, by taking the time to develop a first-in-class rapid antigen LFT - that can be bought by individuals for their medicine cabinets, and be the go-to diagnostic for doctors in hospitals and GPs - @avacta #AVCT is essentially sacrificing several hundred millions...11/n
...in revenue this year, for perhaps billions in revenue over the next three years.

#AVCT has very recently stated that it'll be commencing clinical validation for its LFT shortly. 12/n

This impending revenue from its various #COVID19 diagnostic products will fund the development of #ACT's Therapeutics div - which itself has the potential to reshape the landscape of oncology. No more equity dilution, and financing multiple clinical studies simultaneously. 13/n
Retail investors simply need to exercise patience.

Personally, I think that right now, at 102p / £260m mkt cap, #AVCT is the cheapest it's ever, ever been. As such, I have been more shares today in family accounts to hold for the longer term. 14/n

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More from @MylesMcNulty

9 Nov
An extraordinary day. Firstly, fabulous initial data from Pfizer's vaccine, demonstrating it's 90% effective. An immense scientific breakthrough and a boon for humanity.

From an investment perspective (the raison d'être of this account!): a day of joy and misery, equally! 1/16
Global indices absolutely rocketed - 27/100 FTSE100 Cos ended the session at 10%+. Most sectors were up, whilst precious metals miners and #COVID19-centric stocks got obliterated. The latter group included treatment and testing stocks, and at home/online entertainment/living 2/16
Personally, my PF took an almighty spanking, owing to #AVCT being my largest position by a distance, and also having recently opened a position in #SNG.

A high quality vaccine was always the key risk to #COVID19 plays, but for me, that has always been a medium term risk. 3/16
Read 16 tweets
9 Nov
Exciting development for #N4P today - Launch of Nuvec Oncology Treatment Programme.

This potentially opens up a third colossal market, after vaccine delivery x2 (injection and oral).

The really exciting thing about this Co is that its asset, Nuvec, is already developed and..1/4
...largely refined. It now need only prove consistent in-vivo success for its three target applications (oncology injection; vaccine injection; vaccine oral), and it can start out-licensing Nuvec.

And that's the core of the investment proposition: Nuvec is a platform tech. 2/4
It can be licensed out to multiple parties for multiple targets/applications. #N4P will receive upfront and milestone payments as the licensee takes the drug / vaccine (using Nuvec as the delivery platform) through the clinic.

N4P's cost base is exceptionally low; yet... 3/4
Read 4 tweets
8 Nov
At home antigen testing for #COVID19.

Detection of pre-symptomatic / asymptomatic cases - to a high degree of accuracy - is key.

99% specificity is a must, and ideally sensitivity of 92-93%+.

There should also be a method of logging the result in an objective manner...1/n
...elsewise individuals with positive results could disregard government instructions and go out for work / socialising regardless.

@avacta #AVCT's Affimers are an antibody mimetic - designed to overcome the limitations of monoclonal antibodies.

The evidence indicates... 2n
...that Affimer-based lateral flow tests will likely have a higher specificity than mAb-based LFTs, and possibly higher sensitivity too. Moreover, they are rapid to develop, cheaper to manufacture, and are robust (a benefit both for supply chain issues and for shelf-life).

3/n
Read 5 tweets
27 Sep
#AVCT interims tomorrow.

Comprehensive updates on all work streams of the Therapeutics and Diagnostics divisions will be provided.

Naturally, the content will likely be dominated by the various #COVID19 products under development - and of those, many market participants... 1/n
...(esp. new holders) will only have eyes for the LFT.

I think it’s important to appreciate the number of short term traders - and nervous retail investors - there are in #AVCT at present.

In my view, the near-term SP movement (which I think will be strong, either way)... 2/n
...will be driven by one very simple - but critical - matter: whether #AVCT has been permitted to disclose in its interims the UK Gov’s involvement in the rollout of the LFT.

I think the majority will agree that that involvement is beyond question.

Project #Moonshot... 3/n
Read 9 tweets
24 Sep
New nano-cap position taken via placing: #BIOM @BiomePlastics.

A brief intro, with in depth notes to follow in due course:

BIOM has two operating divisions: Bioplastics (biodegradable / compostable plastics) and Stanelco RF Technologies (advanced radio frequency systems).

1/11
Interims out today, along with a placing at 120p for £1.1m gross. Assuming a successful GM, mkt cap at the current SP of 165p will be £6.1m.

Net cash post GM will be ~£1.8m, so enterprise value at 165p will be ~£4.3m.

My investment is solely based on the Bioplastics div..

2/11
..which is a rapidly growing biz operating in a rapidly expanding market that I believe will become an increasingly hot topic going forward.

I'll be posting more about the products and target markets in due course, but here's a good place to start:

3/11

biomebioplastics.com
Read 11 tweets
24 Sep
We now know that #AVCT's Affimers are being used in at least 5 diagnostics products for #COVID19:

- LFT (with Cytiva)
- BAMS (with Adeptrix)
- ELISA (in-house)
- Microtox BT (with #SKIN)
- Microtox PD (with SKIN)

Working prototypes for all.

And people still doubt Affimers? 1/9
For BAMS and Microtox BT and PD, #AVCT's work is largely complete. It will simply be providing a regular supply of Affimers to Adeptrix and #SKIN, and enjoy steady royalties (which, as many of us are beginning to realise, could be for much longer than initially anticipated).

2/9
This frees up mgmt's time to focus on the proprietary tests, the (all-important!) LFT and the ELISA (which I believe most are under-estimating the earnings potential of).

Whilst some might point out that none of the 5 products have yet been commercialised, I would argue... 3/9
Read 9 tweets

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