#Covid19 is an uneven pandemic”, says @DrTedros at @WHO press conference on #sarscov2. “70% of cases and deaths are in just four countries.”
(Number seems wrong to me, though general point is true of course. Will check.)
@DrTedros @WHO So, according to @WHO’s own numbers US, India, Brazil and Russia account for about 30 million cases, pretty exactly half the global total of now more than 60 million cases.
On deaths: about 660,000 are US, Brazil, India and Mexico, less than half the 1,4 million global deaths.
@DrTedros @WHO Many countries have shown #covid19 can be controlled with existing tools, says @DrTedros. "One of the things all these countries have in common is an emphasis on testing."
@DrTedros @WHO “At the start of the pandemic, just two African countries had laboratory testing capacity for #covid19”, says @drtedros. "By the end of February, 32 countries in Africa had testing capacity, and now all countries can test for #COVID19"
@DrTedros @WHO Testing will remain important as vaccines start to be rolled out, says @drtedros. At first older people and health workers will be immunised. "That will still leave the #COVID19 virus with a lot of room to move, and testing will remain a vital tool for controlling the pandemic"
@DrTedros @WHO "If you don’t know where the virus is, you can’t stop it. If you don’t know who has the virus, you can’t isolate them, care for them or trace their contacts.”, says @drtedros. "Everyone who needs a test should get a test."
@DrTedros @WHO Q about Brazil.
“Most of Central and South America went through a very tough time in terms of cases and deaths”, says @DrMikeRyan. “The numbers have progressively fallen in most countries over a couple of months, but now we see the prospect of numbers increasing again."
@DrTedros @WHO @DrMikeRyan Message from second peak in Europe is that “where countries have taken decisive action to try and reduce community transmission, they've managed to turn that curve around”, says @DrMikeRyan.
@DrTedros @WHO @DrMikeRyan Death rates have dropped, says @DrMikeRyan: “That's been very much down to doctors and nurses, having more time with patients, having more time to give clinical care. If we get back to a situation where intensive care units are overwhelmed, we will see the death rates rise again"
@DrTedros @WHO @DrMikeRyan "All countries need to remain vigilant”, says @mvankerkhove. "It is good to see the measures taking effect and transmission going down. But it is not time to let up. It's time to even scale up."
@DrTedros @WHO @DrMikeRyan @mvankerkhove “There is no reason to have another wave or another surge”, says @mvankerkhove. "It is within our power to be able to keep transmission low. And we've seen dozens of countries show us that it can be brought under control, and it can stay under control."
Correction here by the way from @WHO re the first tweet:
@WHO Q about origins.
“The international team has started to work with the counterparts in China”, says @Peterfoodsafety. “We are starting now to discuss the famous phase 1 studies the studies that need to be conducted in and around Wuhan to look back at what happened in late 2019."
@WHO @Peterfoodsafety WHO has reached out to researchers in Italy claiming serological evidence of infections last year, says @mvankerkhove. “They have generously offered to work with us and to collaborate with us on some further studies looking at those samples."
@WHO @Peterfoodsafety @mvankerkhove Q about results from AstraZeneca vaccine.
“It's too early for us to say anything about what we make of the data and what is needed next”, says @Kate_L_OBrien. "What we really need to see is more than a press release and to really see the data."
@WHO @Peterfoodsafety @mvankerkhove @Kate_L_OBrien “It appears that less than 3000 people were given the schedule with the half dose followed by the full dose of the vaccine and we also understand that those people were all under 55”, says @doctorsoumya. “The numbers are still small to really come to any definitive conclusions."
@WHO @Peterfoodsafety @mvankerkhove @Kate_L_OBrien @doctorsoumya "I must say that it's been very encouraging to see that many of the manufacturers and developers have actually published their protocols”, says @doctorsoumya. “I think that transparency and sharing is extremely important."
@WHO @Peterfoodsafety @mvankerkhove @Kate_L_OBrien @doctorsoumya On global access to vaccines, @DrMikeRyan says: “In situations like this we tend to be unfair first, inequitous. And then eventually the glaring gap is so big and with activists from community level and others, the world has to turn around and find a way to be fair."
@WHO @Peterfoodsafety @mvankerkhove @Kate_L_OBrien @doctorsoumya @DrMikeRyan “In my professional eperience, this is the first time, fairness and equity were built into this project from day one”, says @DrMikeRyan. Thanks @DrTedros for this and calls it “one of the most effective public private partnerships in the history of science."
@WHO @Peterfoodsafety @mvankerkhove @Kate_L_OBrien @doctorsoumya @DrMikeRyan @DrTedros Earlier, @HelenBranswell asked whether it is clear how many people need to be vaccinated to reach herd immunity.
Some modelling studies concluded that around 60 to 70%, of the population would need to be immune, says @Kate_L_OBrien. But really depends on vaccine characteristics.
@WHO @Peterfoodsafety @mvankerkhove @Kate_L_OBrien @doctorsoumya @DrMikeRyan @DrTedros @HelenBranswell Not just whether vaccines prevent infections, she says.
"Do vaccines change the amount of time that you're actually infected? Does it change the density of the infection, does it change the transmissibility to another person? Those are all really important characteristics."
@WHO @Peterfoodsafety @mvankerkhove @Kate_L_OBrien @doctorsoumya @DrMikeRyan @DrTedros @HelenBranswell "This virus is very opportunistic", @DrMikeRyan adds, so herd immunity threshold is not just an absolute number. “It may be that it will take some very clever vaccination strategies to highly target people in our society who are more likely to carry, transmit and superspread"
@WHO @Peterfoodsafety @mvankerkhove @Kate_L_OBrien @doctorsoumya @DrMikeRyan @DrTedros @HelenBranswell “I think we will need some numbers to guide us in terms of policy, but I think we will need to be much more surgical and precise in exactly who we target for vaccination”, says @DrMikeRyan. "It may be much more important to target certain sections of the community."
@WHO @Peterfoodsafety @mvankerkhove @Kate_L_OBrien @doctorsoumya @DrMikeRyan @DrTedros @HelenBranswell “We will need to be very very careful to make sure we send the right messages to people”, says @DrMikeRyan. Says high hopes that vaccines will impact mortality and transmission “But I don't think anyone can promise eradication of this virus, until we understand much more."

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More from @kakape

29 Nov
Interesting piece by @mattapuzzo and others at @nytimes looking at the list of seven demands Trump conveyed to @WHO before he announced withdrawal. No clear strategy apparent. “It was all about my country, my politics, my election”, says @LawrenceGostin. nytimes.com/2020/11/27/wor…
“The third item asked Dr. Tedros to say that countries were right to consider travel restrictions during the pandemic ... Dr. Tedros was wary of being drawn into the American presidential campaign, where travel restrictions were a rallying cry for the Trump campaign.”
“The American requests also called for the W.H.O. to pre-qualify coronavirus drugs and vaccines for use around the world once they were authorized by major regulators in the United States, Canada, Europe or Japan.”
Read 4 tweets
27 Nov
This (German) article by @hfeldwisch raises important questions about the Gangelt publication by @hendrikstreeck et al, that I've been wondering about. It argues that the study underestimates how deadly #sarscov2 is because not all the deaths were counted. medwatch.de/2020/11/26/die…
@hfeldwisch @hendrikstreeck I had wondered about this before because

1. We know that deaths lag cases and studies like this Princess Diamond one (eurosurveillance.org/content/10.280…) take that into account when calculating IFR
2. @hfeldwisch and others had warned before that the Gangelt study was not doing that
@hfeldwisch @hendrikstreeck The study was published in @NatureComms last week. Headline finding was an estimate for the infection fatality rate of #SARSCoV2 of 0,36%.
That was based on 7 deaths in the community of Gangelt compared to 1956 (estimated) infections.
nature.com/articles/s4146…
Read 12 tweets
25 Nov
This new paper on #sarscov2 transmission delves into the data from Hunan province and it is really interesting and the kind of data I would love to see more of. So a short thread science.sciencemag.org/content/early/…
The authors used a dataset of 1,178 infected individuals and their 15,648 close contacts identified in Hunan province between January 16 and April 3 and reconstructed most likely transmission chains.
Superspreading:
The paper confirms previous work showing high overdispersion (so small minority of people leading to most onward transmission): “We find that 80% of secondary infections can be traced back to 15% of #SARSCoV2 infected individuals”.
Estimate k at 0.3
Read 8 tweets
24 Nov
Another week, another sad record.

Last week @WHO recorded the highest weekly numbers yet in this pandemic:
More than 4 million new cases
More than 67,000 new deaths
@WHO The good news is that the rapid increase in global case numbers has slowed down.

The deaths are still catching up, however. In the last four weeks reported deaths were:
45,051
54,835
59,699
67,221
@WHO The countries reporting the most cases last week:
US: >1.1 million cases (+14%)
India: >280,000 (-8%)
Italy: >230,000 (-3%)
Brazil: >200,000 (+17%)
France: >170,000 (-16%)

That mirrors the global situation with cases decreasing in Europe and increasing in the Americas.
Read 9 tweets
24 Nov
Some new data came out today on the “other” #covid19 vaccine, Russia’s Sputnik V:
Press release claims efficacy of
91,4% - 28 days after 1st shot
95% - 42 days after 1st shot

Apart from usual caveats it is important to note that this comes from analysis of just 39 infections:
My colleague @sciencecohen wrote about the first batch of results earlier this month and why they didn’t pass the “smell test" sciencemag.org/news/2020/11/r…
@sciencecohen In press conference Kirill Dimitriev, CEO of Russian Direct Investment Fund, says vaccine will be produced in lyophilized form to be stored at 2-8 degrees C.
Vaccine to be delivered internationally from January 2021 for up to 500 million people that year. Less than $10 per shot.
Read 4 tweets
23 Nov
“The light at the end of this long, dark tunnel is growing brighter”, says @DrTedros at @who #covid19 presser. "There is now real hope that vaccines – in combination with other tried and tested public health measures – will help to end the #COVID19 pandemic.”
@DrTedros @WHO No vaccines have ever been developed this fast and the ”scientific community has set a new standard for vaccine development”, says @drtedros. "Now the international community must set a new standard for access."
@DrTedros @WHO "The urgency with which #covid19 vaccines have been developed must be matched by the same urgency to distribute them fairly”, says @drtedros. “There is now a real risk that the poorest and most vulnerable will be trampled in the stampede for vaccines."
Read 15 tweets

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