Today we broke the US pandemic thresholds for both hospitalizations, over 100,000 and deaths, over 2,700 deaths.
@COVID19Tracking
It's horrifying and we should be pulling out all the stops to prevent further M & M. We can do this if there is the will.
The deaths lag the hospitalizations, the spurious dip related to the holiday data issue. Their close tracking is unequivocal in this 3rd surge.
The hospital and healthcare workforce capacity has been exceeded in many parts to the country, requiring urgent intervention
To do this we need to stop the spread of ~200,000 new confirmed cases again today. Universal mask mandates, enforced, distribute surgical mask supply and rapid home tests out to all households now, shut down hot spots, cluster bust, etc, whatever it takes
The US paralysis in response is noteworthy and represents a distinct outlier from all the countries around the world that have been through (or are going through) their 2nd wave.

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Eric Topol

Eric Topol Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @EricTopol

30 Nov
Superhuman #SARSCoV2 immunity
Just published @NatureMedicine
nature.com/articles/s4159…
Our essay on vaccines that give humans immune responses superior to those generated in response to infection, now including #SARSCoV2
@scrippsresearch @ScrippsRTI w/ Dennis Burton Image
To elaborate on the concept of superhuman vaccine immunity:
Each of the 3 examples in our piece are for different reasons.
1. HPV—best, since the human response is weak
2. Tetanus—small amounts of toxin don't elicit strong response)
3. H Flu—the bacterium is sugar coated
2/
This is different from vaccine efficacy.
Take measles. The natural human response to infection provides durable efficacy but the vaccine requires multiple shots and is without lifelong protection. 3/ Image
Read 10 tweets
28 Nov
This will go down in history as one of science and medical research's greatest achievements. Perhaps the most impressive.
I put together a preliminary timeline of some key milestones to show how several years of work were compressed into months.
There are several points noteworthy related to this timeline:
1. Moderna had a head-start, so why didn't their Phase 3 trial finish first?
Part of #OperationWarpSpeed (OWS), they were requested to slow down enrollment to get better minority representation
nytimes.com/2020/11/21/us/…
2. 3 scientists led the way
Katalin Karikó, worked on a mRNA vaccine for ~30 years, was demoted from @PennMedicine d/t losing her grants, went to @moderna_tx
statnews.com/2020/11/10/the…
and the husband and wife team @BioNTech_Group
nytimes.com/2020/11/10/bus…
Read 5 tweets
24 Nov
Randomized, placebo-controlled trial of convalescent plasma(CP) for severe #COVID19: "no significant differences...in clinical status or overall mortality" @NEJM
"We believe the use of CP as a standard of care....should be reevaluated." nejm.org/doi/full/10.10…
And also today yet another negative trial for hydroxychloroquine as a prophylactic intervention.
The most over-studied, under-performing, repurposed drug in modern times.
nejm.org/doi/full/10.10…
Incredible. A faculty doctor @UCLAHealth @dgsomucla
says we are too cautious by demanding evidence for #COVID19 medications. And that hydroxychloroquine has strong data to support its use. That we're killing patients.
wsj.com/articles/too-m…
Read 4 tweets
24 Nov
A new, in-depth review of masks, the different types (cloth, surgical, N95) droplets, and aerosols for #SARSCoV2 context
aip.scitation.org/doi/pdf/10.106… @AIP_Publishing 😷😷
Their conclusion on highly efficacious facemarks eradicating the pandemic, simulation of the surgical mask efficacy with 3-layer cotton mask, and the importance of how long a mask is worn w/r to protection impact
Read 5 tweets
22 Nov
The good news is that many of the worst-hit states for the US pandemic have started their descent.
Nebraska, New Mexico still on a sharp ascent
South Dakota peaked with the highest death rate per capita for any place in the global pandemic
Nice that the @CDCgov is discouraging travel at Thanksgiving. Where were they when 450,000 people were assembling for the #SturgisRally?
Read 4 tweets
20 Nov
Today the @WHO rejects Remdesivir for #COVID19.
The same drug the @US_FDA gave a full approval.
Because the @WHO reviewed all the data and made the right call.
bmj.com/content/bmj/37…
@bmj_latest
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!