My wife is currently getting her COVID vaccine @OUHospitals.

Feeling far more emotional about this than I had expected. #Science #VaccinesWork
And on the day that BioNTech/Pfizer publish their safety and efficacy data in @NEJM.

There's not much in medicine that can give results this stark.

nejm.org/doi/full/10.10…
Oh, and apparently the vaccine comes with a whole world of chocolate bourbon biscuits while you wait.
Not like you needed any more encouragement
I mean, it's hard to overstate how incredible the whole thing is.

SARS-CoV-2 was first described less than 12 months ago and now we have a national vaccination programme. I am in total awe of everyone involved from the scientists to the logistics and operations. Thank you.🤯🙏

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More from @ADMBriggs

10 Dec
Wk 27 Test and Trace - 26/11/20 to 02/12/20

Performance continues to get better as we come out of lockdown, but case numbers already starting to rise again across some parts of the country.

gov.uk/government/pub…
The number of people being tested has dropped a little, but the number of positive cases has fallen by 13%.
But we know from both PHE surveillance and gov.uk daily data, that T&T case numbers are going to plateau and start rising again next week.
Read 17 tweets
10 Dec
This week's @PHE_uk Flu and COVID surveillance report came out earlier. Covering 30/11 - 06/12

Tl,dr: In the week we came out of lockdown, case rates and hospital admissions are already plateauing nationally and rising in some regions. 😔

gov.uk/government/sta…
As we know, the fall in cases has plateaued and may now be rising.

Lockdown only ended on 2nd December. This is really concerning. ImageImage
The plateauing is in all ages (although perhaps worth keeping an eye on 5-9y/o) Image
Read 15 tweets
5 Dec
Our new short analysis in @TheLancet with @cfraserepi.

Is Test and Trace exacerbating inequalities?

Tl,dr: the more deprived somewhere is, the less likely cases and contacts are reached by Test and Trace

thelancet.com/journals/lance…
The disproportionate effects of COVID on more deprived populations are well known.

People in more deprived areas are more likely to get infected and to die.

See @PHE_uk/@ProfKevinFenton's excellent review

gov.uk/government/pub…
And the detrimental impact of social restrictions/lockdown is also greater among more vulnerable populations

See this @bmj_latest piece from @sandrogalea and colleagues:
bmj.com/content/371/bm…
Read 17 tweets
3 Dec
It's that time of the week.

Test and Trace performance figures for 19-25th Nov. Wk 26.

Tl,dr: some changes to how cases are managed, and overall as cases fall, the systems showing signs of improvement.

Summary in pic, detail in thread.

gov.uk/government/pub…
A 5% drop in the number of people getting tested this week (to 1.66m), but a 28% drop in cases.
Drawing conclusions about falling positivity rates over time is getting increasingly tricky as testing among asymptomatic people is rolled out. As have said previously, reporting symptomatic separately to asymptomatic would hugely help with understanding the data.
Read 21 tweets
3 Dec
Latest PHE flu and surveillance report now out.

Looks at 23/11 to 28/11

Case rates falling, flu remains low, and as ever, big regional/age/ethnicity/deprivation variation.

gov.uk/government/sta…
We we know, cases and case rates are falling fairly fast. 83,764 cases in the week covered, 45% from the peak of 150,943 two weeks previously.
Case rates falling across all ages - including those over 60 yrs (more likely to be hospitalised).

Although rates of decline are slowest in <9 yrs and >70yrs.
Read 18 tweets
26 Nov
Wk 25 T&T report thread. 12 - 18 Nov.

tl,dr: cases down, contacts up, improvements stalled, and £37bn is a lot of money.

Summary in pic, details in thread.
gov.uk/government/pub…
Interesting that number of individuals tested down by 1% this week (although that's still 1.74m people).
This includes the lateral flow devices being used in Liverpool and some other settings (reported in pillar 2).
Cases fell for the first time since mid-August. Down 9% to 152,660, and positivity also down. This is consistent with PHE data today, as well as ONS survey.
Read 21 tweets

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