1/4: An honor to be vaccinated against #COVID19 tonight ⁦@TexasChildrens⁩ ⁦@bcmhouston⁩, dose 1/2 of the Pfizer BioNTech #vaccine
2/4: Also with mixed emotions X3.
1. Sadness & Grief: Reflecting on the 300,000 Americans who lost their lives from #COVID19. Those who never had this opportunity, because our nation could never organize a national plan roadmap. How I tried to push WH to implement an Oct 1 Plan
3/4: Gratitude: Thankful to @pfizer @BioNTech_Group and to the leadership of OpWarpSpeed, including our @HHSGov agencies: @US_FDA @CDCgov and to the @NIH supporting more than a decade of R&D on coronavirus vaccines including ours now being produced and tested in India 🇮🇳
4/4: Apprehension: Hoping things go well with the US vaccination program this month and that @moderna_tx @AstraZeneca @JNJNews @Novavax vaccines get up, we’ll need them. Also our @TexasChildrens @BCM_TropMed vaccine with @biological_e deeply worried about the LMICs

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More from @PeterHotez

14 Dec
Many thanks ⁦@AymanM⁩ hosting me ⁦@MSNBC⁩ on this first full day of #covid19 vaccination in America. I explained why the Pfizer-BioNTech vaccine is both effect and safe and = the culmination of 17 years of R&D from a community of CoV virologists including our group
The vaccine then went through a rigorous phase 1 and 2 trials, showing that we need to 2 doses to get the virus 🦠 neutralizing antibodies up, and then a large 44,000 person phase 3 trial equivalent in size to any typical vaccine trial in the US
After that it will go through rigorous post EUA monitoring through VAERS VSD and additional FDA and CDC monitoring.
Read 5 tweets
10 Dec
1/3: Always an honor to be on ⁦@CNNTonight⁩ with ⁦@donlemon⁩ the night before possible first release of #covid19 vaccines to the American people. Recent polls show high rates of vaccine hesitancy and refusal, here are the + and - forces...
2/3: On the + side I think as people see their family, friends, colleagues get vaccinated, things will pick up. Also the high level of reported protective immunity will be a driver...
3/3: On the - side there is no real communication strategy from OWS even though it is a strong program scientifically. The void is filled with pharma CEOs who are mostly poor and tone deaf communicators + powerful antivaccine groups dominating internet + Russian disinformation
Read 4 tweets
7 Dec
1/4: My comments this AM with ⁦@apoorva_nyc⁩ in ⁦@nytimes⁩, I stated how the “stars would need to align” in order to meet OpWarpSpeed projections of vaccinating US population and ultimately interrupting virus transmission nytimes.com/2020/12/06/us/…
2/4: We have two performance hopes or expectations for #COVID19 vaccines: 1) To keep you or your family out of the hospital or ICU and save your life (so far that seems to be happening), but also 2) if enough people are vaccinated then virus 🦠 transmission stops
3/4: Second bar is a high one requiring following stars to align: 1) the vaccine can also halt virus shedding, asymptomatic transmission and we haven’t established that yet, studies planned, 2) we estimated with modelers @CUNYSPH @bruce_y_lee that 60-80% US population vaccinated
Read 4 tweets
7 Dec
You are not wrong. But it never was that way before? @NASA was launched in by Eisenhower, @PEPFAR #NTDs by W, I know because I worked with Dr Fauci to make it happen. Ok maybe Reagan wasn’t great, but not like this. Our nation was built on science. What the heck happened?
And how do we fix this? When i was chair 🪑 of microbiology at @GWSMHS for 11 years (loved it) I learned that you can get anything done you want as long as you don’t need to take the credit for it and are willing to reach across the aisle
Back then I would think nothing of going to Sen. Sam Brownback’s (R-KS) prayer 🙏 breakfast and walking down the hall to meet with Sen Patrick Leahy (D-VT). Two total ideological opposites, but work together on #NTDs? Not a problem
Read 4 tweets
5 Dec
1/3: Many thanks ⁦@AnaCabrera⁩ for hosting me @CNN re: widespread #covidvaccine hesitancy due to an absent communication plan from OpWarpSpeed, bungled messaging and press releases from pharma CEOs, and antivaccine dominance on internet, social media and ecommerce sites
2/3: Antivaccine messages coming from several sources: 1) US “health freedom” and specific antivaccine organizations that monetize internet, sell fake books and wellness products, as well as PACs linked to political extremism, 2) Russian weaponized health communication
3/3: These antivaccine organizations now targeting specific groups with misinformation and inflammatory language, for example Orthodox Jewish population comparing vaccines to the Holocaust and African American community comparing vaccines to Tuskegee, staging rallies in Harlem NY
Read 5 tweets
5 Dec
1/3: Many thanks ⁦@MartinSavidge⁩ for hosting me @CNN discussing two necessary performance features of OpWarpSpeed #COVID19 vaccines: 1) reducing severe infection and keeping you out of hospital and the ICU, and 2) interrupting virus transmission through herd immunity
2/3: I think we checked the box on the first one, which is great, but herd immunity is a high bar. We know this through our studies with @bruce_y_lee @CUNYSPH finding we’ll need 70-80% coverage with a vaccine that also stops virus 🦠 shedding - those shedding studies in progress
3/3: And to achieve 70-80% coverage in US we’ll need: 1) multiple different types of vaccines, mRNA vaccines alone probably won’t get us there, 2) to also vaccinate adolescents children, studies underway, 3) launch a communication strategy, 4) halt antivaccine disinformation
Read 4 tweets

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