Pregnant and unsure about the #COVID19 vaccine? You’re not alone. Got vaccinated today at 31 weeks and feel very fortunate. But it’s complicated. Here’s why I decided to go for it. 1/
Context: I'm a high-risk pregnancy specialist & scientist so I've thought a lot about the vaccine and have discussed pros/cons at length w colleagues. Decision making in pregnancy is a complex process in general and highly personal. COVID vaccination is no exception. 2/
Questions from well meaning people, lack of data, conflicting guidelines (US vs UK), judgy looks, all contribute to hesitancy and anxiety. 3/
My reasons:
*I am routinely exposed to #COVID19 at work. Anxiety about getting infected has ⬆️ sig during pregnancy. The thought of bringing COVID home to my family, transmitting to pts or coworkers is exhausting. For me, vaccine = relief. Plus passive immunity for baby. 4/
*Data are impressive and the science is solid. Tough to find any other medical intervention that works THIS well. 5/ nejm.org/doi/full/10.10…
*Why not wait for more data? Seriously considered this. But the data will simply not be here soon enough.
Asked myself, if I don't get the vaccine now and then get COVID, will I regret my decision to pass on a highly effective vaccine? YES.
6/
Ultimately, I know the risks of COVID in preg and have seen too many pregnant pts with severe dz. It's important to acknowledge the unknowns and respect ppl w questions & those who choose to wait based on their personal situation, anxieties, etc. 7/
STOX1 is a TF and predicted #preeclampsia risk gene IDed through family-based genetic linkage studies (van Dijk, @NatureGenet 2005). A variant in the DNA-binding domain was proposed to alter protein function ➡️ preE susceptibility. But LOF model had not been studied. 🐁 2/
*We found that loss of Stox1 ➡️ gHTN assd w placental hypoxia + abnormal ECM deposition.
*We observed activation of the uteroplacental renin-angiotensin system in Stox1 KO mice.
*Treatment w an ARB, losartan, rescued the gHTN phenotype, validating the mechanism. 3/