THREAD

1/ Read this. This is "global health"? This is our "solidarity"? This is extractive.

Vaccines produced in South Africa & tested on South Africans are then deemed safe, & first given to Americans, British, & others in wealthy countries.
nytimes.com/2020/12/28/wor…
2/ "Poor & middle-income nations, largely unable to compete in the open market, rely on a complex vaccine sharing scheme called Covax."

But as the article mentions, this 'aid' is conditional; some countries are not "poor enough" to qualify, but also can't afford enough vaccines
3/
Within South Africa (& many countries), the wealthy will buy vaccines to protect themselves.

The poor are in a gamble w/ their lives.

**“We’ll all be dead then,” said Prudence Nonzamedyantyi, 46, a housekeeper from the same township.** (quote from the article)
4/ "South African medical advisers say the Covax system is vital but also deeply frustrating. Governments must pay up front without knowing what vaccine they will receive or getting any guarantees on when the doses will arrive."
5/ "Covax estimates the price per dose but offers little recourse if the cost is ultimately much higher. Countries must assume all of the risk if the vaccine fails or if anything goes wrong."

This sounds problematic. Again, this is "global health"? This is solidarity? No.
6/ None of us are safe until we are all safe, ESP those most vulnerable among us; those working on the frontline w/ highest exposure risk; those living in crowded housing w/ highest transmission risk.

This epidemic is one of inequities before viruses.
7/ End of last yr, I wrote about how epidemics showed us that global solidarity was largely a myth; what was more clear was global health *security*-- rich countries making sure they protected themselves against epidemics originating in poor countries. journalofethics.ama-assn.org/article/how-sh… Image
8/ We see the same playing out now.

I had seen a tweet recently showing a global map of current vaccine distribution which was eerily demonstrative of what I'm talking about (share it if someone else has seen it, can't find it now)
9/ With rapidly rising case count in South Africa + news of variant w/ more effective transmission characteristics, one could easily argue focusing vaccination efforts right here; but, as the original article makes clear, global politics and $ dominate.

reuters.com/article/us-hea…

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More from @AbraarKaran

31 Dec
1/
mRNA1273 (Moderna) vaccine- Phase 3 trial

2 doses, 28 days apart (black arrows)

28,207 in per-protocol analysis

Primary end-point: preventing symptomatic infections w/ onset at least 14 days after 2nd dose

Overall: 94.1% vaccine efficacy

nejm.org/doi/full/10.10… Image
2/ Key secondary end-point: preventing severe #Covid19 disease

Vaccine group- 0 severe cases

Placebo group- 30 severe cases

Vaccine efficacy of 100% in preventing severe disease
3/ "In addition, although our trial showed that mRNA-1273 reduces the incidence of symptomatic SARS-CoV-2 infection, the data were not sufficient to assess asymptomatic infection" (cont)

#covid19
Read 6 tweets
29 Dec
First reported case of #COVID19 #B117 variant in the United States in a Colorado man with no relevant travel history to UK. What this suggests is community transmission of new variant.

latimes.com/world-nation/s… Image
2/ New variant is thought to be more transmissible but not more severe in terms of the disease it causes. BUT- more transmissible can very much be more problematic than more fatal (see thread/tweets below)

3/ Longer thread here linking to a number of articles as well as different responses by various countries in terms of travel restrictions (which ultimately make less sense/are less efficient for control when you already have community transmission) re #b117 #covid19 variant
Read 6 tweets
29 Dec
Check out this new piece from Ed Yong in @TheAtlantic on pandemic year two

Thanks to Ed for having me share some of my thoughts here alongside a number of colleagues

We have an immense year ahead of us

#covid19
2/ “There will be a whole lot of pain in the first quarter” of 2021 --Anthony Fauci told Ed in this piece.

I agree. I am hopeful that summer 2021 will be our first major exhale in a while.
3/ One of the most consequential parts of reaching a better summer 2021 is going to be our vaccination strategy, which we aren't doing well right now. Read this thread below

Read 7 tweets
26 Dec
New #covid19 variant #B117 has led to vastly different responses around the globe.

Japan, for instance, has stopped all foreigners from entering until the end of January— they had detected cases of B117 as of Friday. washingtonpost.com/world/2020/12/…
2/ Canada as of now has restricted all incoming flights from the UK until January 6th #covid19

gov.uk/foreign-travel…
3/ France eased restrictions for certain categories of people as below #covid19

gov.uk/foreign-travel…
Read 12 tweets
26 Dec
Some thoughts on new UK variant #b117 (not a virologist- purely from a public health response view)

1/ Seems this was inevitable & we will see more variants of concern over time. We will constantly have to re-evaluate response measures #covid19
2/
if vaccines turn out to be less effective against new variants (big “if” here), this will be another reminder that fundamentals of public health + multilayered strategy always name of the game— a vaccine is one part of that- not the whole strategy. No short cuts #covid19
3/
Better masks & personal protective equipment for the general public is well overdue; we know masks work; we know aerosols contribute to spread; we know not all masks have effective aerosol protection- better masks are a win-win, & aren’t affected by new variants
#covid19
Read 9 tweets
24 Dec
1/
Currently reading a book about the history of epidemics and society.

“What made the bubonic plague especially fearful was that it presented communities with the antithesis of the “art of dying”...death from plague was sudden; people died alone.”
2/
Ask any doctor- especially those working ICUs— about the pandemic deaths that separated families from loved ones. Patients died with nurses and doctors by their side; but many without their families.
3/ I remember one especially terrible case I had cared for in an emergency department back in April. The whole family had been infected as they lived in a multigenerational home; a son was sick in the ED; his father died alone in an ICU at the same time.
Read 4 tweets

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