Share this page!

Julien Potet Profile picture
Twitter logo
11 Jan, 5 tweets, 3 min read
Bangladesh: large RCT (n=606) of #mouthwash, gargling, nasal spraying & eye drops w/ 1% povidone-iodine (PVP-I, aka #Betadine) for #COVID_19. Every 4 hours for 4 weeks.
Impressive results.
bioresearchcommunications.com/index.php/brc/…
h/t @Covid19Crusher
Mouthwash solutions of PVP-I can be easily purchased OTC in many countries. Nasal sprays and eye drops are less easily accessible (i.e. not available OTC in France).
There have been other in vivo and in vitro studies over the last months. A tiny RCT from Singapore had previously found encouraging results.
There are a few other RCTs of PVP-I mouthwashing / gargling / spraying that are currently recruting. covid.inato.com/search?query=p…
Finally, I need to confess that I have used mouthwashes of PVP-I as a prophylactic measure on multiple occasions over the last months... I think I'll continue to do it...

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Julien Potet

Julien Potet Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @julienpotet

Julien Potet Profile picture
7 Dec 20
1/
 There have been several small RCTs over the last weeks suggesting a clinical benefit for #ivermectin for #COVID_19.

It’s time for a MEGA THREAD on ivermectin, aka the “wonder drug”!

Let's start the show !🔥🔥🔥
2/
Ivermectin belongs to the family of avermectins, which are natural fermentation products of soil bacteria. A Nobel Prize of Medicine was awarded for their discovery. Image
3/
Ivermectin is indicated for several parasitic infections: onchocerciasis, lymphatic filariasis, strongyloidiasis, scabies. It works on head lice too. #NTDs

But ivermectin may have a broader therapeutic benefit. Hence its nickname, the “wonder drug”.
pubmed.ncbi.nlm.nih.gov/28196978/
Read 20 tweets
Julien Potet Profile picture
19 Apr 20
1/
In this thread, I’ll speak about #tocilizumab and challenges to access it. Tocilizumab is an anti-IL-6-receptor monoclonal antibody. It is a promising investigational drug to treat the cytokine storm associated with severe #COVID19.
2/
The cytokine storm (aka cytokine release syndrome) occurs when a high number of white blood cells are activated and release inflammatory cytokines, such as IL-6, which in turn activate more white blood cells.
3/
Tocilizumab is not an antiviral agent. Like other host focused therapies for COVID19, tocilizumab can be used in association with an effective antiviral and their combined actions may be complementary.
Read 22 tweets
Julien Potet Profile picture
12 Mar 20
In this thread, I’ll share what is known about access to #remdesivir, one of the leading therapeutic candidates against #COVID19. Originator company @GileadSciences ($GILD). As an introduction, I suggest you should read this very detailed article. biopharmadive.com/news/coronavir… 1/n
Remdesivir (aka GS-5734) inhibits RNA-dependent RNA polymerase. Broad-spectrum antiviral. Injectable (IV). Wasn’t found as clinically effective for #Ebola as monoclonal antibodies. Here is the formula. The synthesis of GS-5734 is described here. pubs.acs.org/doi/full/10.10… 2/n
How much of remdesivir is available now ? Unclear. In Feb 2019, when drug was still a promising candidate for #Ebola, Gilead planned to have 25kg + 4x40g of (unfinished) drug substance by 2020, equivalent to 148,000 treatment courses. Unknown if it materialized. 3/n
Read 12 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!

Like this author's thread?

Get emails when @julienpotet has new unrolls!

Check out other threads from @julienpotet!

Read all threads by @julienpotet