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Julien Potet Profile picture
Julien Potet
@julienpotet
#NTDs advisor @msf_access. #snakebite, #Ebola, #malaria, #VaccinesWork. Also in a quest for an affordable & effective treatment for #Covid_19.
May 20, 2022 • 10 tweets • 3 min read
Bon... alors que je suis actuellement en 🇨🇫, l'un des pays endémiques pour le #monkeypox, voilà qu'une épidémie internationale inédite prend une ampleur très inquiétante...
Quelques considérations sous forme de 🧵... L'Institut Pasteur en 🇨🇫 @I_P_Bangui est l'une des institutions qui a le plus d'expérience dans la surveillance & la prise en charge du monkeypox.
L'antiviral recommandé pour monkeypox, le tecovirimat, y fait l'objet d'un programme d'accès compassionnel pasteur-bangui.org/6-decembre-202…
Aug 12, 2021 • 13 tweets • 7 min read
🚨Interim results of @TogetherTrial of ivermectin and fluvoxamine for early treatment of #COVID_19 🚨
#ivermectin : no significant effect
#fluvoxamine: ↘️ risk of hospitalization by 31%
These important results deserve a🧵 1/n rethinkingclinicaltrials.org/news/august-6-… Trial took place in 10 sites in Minas Gerais, 🇧🇷. 2/n
May 6, 2021 • 9 tweets • 4 min read
While the decision of the 🇺🇸 governement to support an IP #waiver on #COVID_19 vaccines is a step in the right direction, many other things now need to happen. 🧵1/9 For the waiver to effectively accelerate vaccine availability, significant 💰 investments are needed, as well as "tech transfers". 2/9
Mar 11, 2021 • 8 tweets • 5 min read
1/
 🔥EXCELLENT results for Phase III multicentric double-blind RCT of #proxalutamide for hospitalized #COVID_19 patients🔥
n=588
Study led by @FlavioCadegiani in 🇧🇷
92% reduction in mortality ! prnewswire.com/news-releases/… 2/
Keep in mind that this is a press release, not a scientific publication.
A point is particularly unclear in the press release, i.e. authors claim 588 patients were enrolled, but then later write they were 294 in proxalutamide group & 296 in control group.
294+296=590≠588.
Mar 10, 2021 • 6 tweets • 3 min read
1/
 Excellent results for phase 3 placebo-controlled RCT in 🇺🇸 among mild-to-moderate #COVID_19 patients at high risk of clinical deterioration.
Cocktail of 700mg of #bamlanivimab & 1,400mg of #etesevimab reduced risk of hospitalizations & death by 87%. 2/
 This press release needs to be taken with grain of salt. Among other limitations, it says nothing about different variants of concern.
Feb 12, 2021 • 6 tweets • 3 min read
1/
 Large RCT (n=930) in Barcelona, 🇪🇸: #calcifediol vs control among hospitalized #COVID_19 patients.
Strong clinical benefit: ↘️ICU admission & ↘️mortality.
Unclear to me why this preprint got unnoticed (published three weeks ago) !
#VitaminD
papers.ssrn.com/sol3/papers.cf… 2/
These new results confirm similar positive results for calcifediol generated in Cordoba in a smaller pilot RCT
Feb 11, 2021 • 18 tweets • 11 min read
Live-tweeting about the 1st online conference on noma disease. Stay tune !
#ZeroNoma #NTDs Opening message by @PeterHotez. Peter is among other things editor of @PLOSNTDs. The journal recently agreed to include noma in the list of eligible diseases for publication. #NTDs
Feb 6, 2021 • 11 tweets • 6 min read
Quelques éléments de contexte pour expliquer le communiqué de presse de @Merck qui conclut à l'absence quasi totale de preuves en faveur de l'#ivermectine (IVM) pour #COVID_19 🧵merck.com/news/merck-sta… Petit disclaimer pour commencer : je ne suis ni "pro-IVM", ni "anti-IVM". Ces catégories n'existent que dans les esprits des gens qui politisent tout et n'importe quoi.
Jan 11, 2021 • 5 tweets • 3 min read
Bangladesh: large RCT (n=606) of #mouthwash, gargling, nasal spraying & eye drops w/ 1% povidone-iodine (PVP-I, aka #Betadine) for #COVID_19. Every 4 hours for 4 weeks.
Impressive results.
bioresearchcommunications.com/index.php/brc/…
h/t @Covid19Crusher Mouthwash solutions of PVP-I can be easily purchased OTC in many countries. Nasal sprays and eye drops are less easily accessible (i.e. not available OTC in France).
Dec 7, 2020 • 20 tweets • 11 min read
1/
 There have been several small RCTs over the last weeks suggesting a clinical benefit for #ivermectin for #COVID_19.

It’s time for a MEGA THREAD on ivermectin, aka the “wonder drug”!

Let's start the show !🔥🔥🔥 2/
Ivermectin belongs to the family of avermectins, which are natural fermentation products of soil bacteria. A Nobel Prize of Medicine was awarded for their discovery. Image
Apr 19, 2020 • 22 tweets • 10 min read
1/
In this thread, I’ll speak about #tocilizumab and challenges to access it. Tocilizumab is an anti-IL-6-receptor monoclonal antibody. It is a promising investigational drug to treat the cytokine storm associated with severe #COVID19. 2/
The cytokine storm (aka cytokine release syndrome) occurs when a high number of white blood cells are activated and release inflammatory cytokines, such as IL-6, which in turn activate more white blood cells.
Mar 12, 2020 • 12 tweets • 7 min read
In this thread, I’ll share what is known about access to #remdesivir, one of the leading therapeutic candidates against #COVID19. Originator company @GileadSciences ($GILD). As an introduction, I suggest you should read this very detailed article. biopharmadive.com/news/coronavir… 1/n Remdesivir (aka GS-5734) inhibits RNA-dependent RNA polymerase. Broad-spectrum antiviral. Injectable (IV). Wasn’t found as clinically effective for #Ebola as monoclonal antibodies. Here is the formula. The synthesis of GS-5734 is described here. pubs.acs.org/doi/full/10.10… 2/n