Thread by @DrEricDing

💡EARLY CONVALESCENT PLASMA WORKS—2 large studies shows early use of high antibody concentration CP therapy prevents severe #COVID19.

📌Study 1: Trial of high titer CP vs placebo—cuts severe COVID risk by 1/2!

📌Study 2: High titer CP cuts death risk by 1/3 vs low titer CP🧵

2) Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults.

➡️Conclusion: Early administration of high-titer convalescent plasma against SARS-CoV-2 to mildly ill infected older adults reduced the progression of #COVID19 by 48%.

nejm.org/doi/full/10.10…

3) Among patients hospitalized with Covid who were not receiving mechanical ventilation, transfusion of plasma with higher anti–#SARSCoV2 IgG antibody levels was associated with a lower risk of death than transfusion of plasma with lower antibody levels.
nejm.org/doi/full/10.10…

4) Speaking of antibodies in blood... also amazing study of mother to child transfer across the placenta of anti #SARSCoV2 antibodies!! And good findings and relevance for vaccines... see 🧵 below.

https://twitter.com/drericding/status/1356063288006684672

5) that said, we do know that in some cases there might be more mutations observed, as a reader points out. But this was in an immunosuppressed person. medrxiv.org/content/10.110…

6) The beauty of CP is that its antibodies are effectively diverse, unlike monoclonal antibody drugs that are one trick ponies that can easily be evaded by a virus over time.