Mia Malan Profile picture
10 Feb, 8 tweets, 3 min read
[Thread] 1. SA will be getting Pfizer jabs to use in #VaccineRolloutSA. Those jabs need to be stored in special freezers at -70 degrees Celsius. We don't have many of those freezers. So how will SA cope?
2. #Mkhize: Pfizer is sending its #CovidVaccines to SA in packaging that allows for the jabs to remain stable for a certain period until they get to a freezer. We've also had companies offering us access to the special freezers required so we can store the jabs safely.
3. Here's more background on the challenges with maintaining the cold chain with Pfizer jabs (some of these challenges have now been addressed with packaging that keeps the jabs at the right temp and more freezers that have become available). bit.ly/3q8UFHs
4. So how exactly is Pfizer helping countries to store their jabs correctly? First of all, they have a "just-in-time" system: They ship frozen vials to countries as close as possible to the date of use. bit.ly/2LEDL4E
5. The Pfizer jabs arrive in specially designed, temperature-controlled thermal shippers that use dry ice to maintain the recommended storage temperature of -70°C for up to 10 days while they're unopened (so there's time to get them to vaccination sites). bit.ly/2LEDL4E
6. When a country receives Pfizer jabs, they have a few options for storage. The first option is ultra-low-temperature freezers, which are commercially available and can extend shelf life for up to 6 months (but most countries don't have enough of these). bit.ly/2LEDL4E
7. Pfizer also uses thermal shippers, in which doses will arrive. The shippers can be used as temporary storage units by refilling them with dry ice every 5 days for up to 30 days of storage. bit.ly/2LEDL4E
8. After storage for up to 30 days in a Pfizer thermal shipper, vaccination centres can transfer the vials to normal frigdes (2-8°C ) for a total of up to 35 days. Once thawed and stored under 2-8°C conditions, the vials cannot be re-frozen or stored under frozen conditions.

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More from @miamalan

12 Feb
[Thread] 1. Would criminals steal and falsify #CovidVaccines in #Africa? It has started. On 19 November, South Africa received its first freight of falsified #Covid19 “vaccines”. bit.ly/3qcHXYm Image
2. The falsified #CovidVaccines were found in a warehouse in Germiston. Police tracked the freight from OR Tambo and found prefilled syringes in boxes with Chinese labels. There were strong signs they were going to be sold as genuine #CovidVaccines. bit.ly/3qcHXYm
3. Interpol says the falsified "jabs" had been advertised for sale on a Chinese social media app, WeChat. They had been imported from Singapore as “cosmetic injections”. Two people have been arrested. Police are trying to trace if any were released in SA. bit.ly/3qcHXYm
Read 15 tweets
10 Feb
#Mkhize: The process of Aspen (in SA) filling and packing Johnson&Johnson #CovidVaccines is going well. We anticipate they will have their first batch ready in March. They need to hold manufactured stock for a month (safety procedure) before it can be released.
#Mkhize: Aspen says they want to serve SA and make Johnson&Johnson vaccines available to the country. But it's J&J who decides if, and how many, of the vaccines packaged by Aspen in SA our country can get.
#Mkhize: J&J has told me they're committed to making their #CovidVaccines available to SA. (On Sunday, principal investigator Glenda Gray said J&J will make an announcement about this later this week).
Read 4 tweets
10 Feb
#Mkhize: [Thread] We want to use the best #CovidVaccine for SA. The #501YV2 variant has impacted on the efficacy of jabs. The results showing the impact on the #astrazenecavaccine only became available on Fri. We now know it doesn't prevent mild/moderate #COVID19 disease in SA.
#Mkhize: Government's process of procuring the #AstraZenecaVaccine started before the new results on lack of efficacy in South Africa became available.
#Mkhize: The public has concerns about the expiry date of the #AstraZenecaVaccine. The vaccine has not expired yet. The doses would have been used up by the April expiry date with our original #VaccineforSouthAfrica roll-out strategy.
Read 7 tweets
7 Feb
Madhi: When researchers looked at protection that the #AstraZeneca jab provided against mild to moderate #Covid19 disease, there was considerable protection against the original form of the virus. But the antibodies induced by the jab didn't work nearly as well for #501YV2.
There was very little difference between the protection the vaccine provided for people infected with #501YV2 and the placebo group (the group that was infected with a saline solution instead of the #AstraZeneca vaccine).
Madhi's team found that the #AstraZeneca vaccine provided almost no protection against the #501YV2 variant, also known as the #B1351 variant. There is hope: the Johnson&Johnson (Jansen) jab provides 89% protection against severe #Covid19 caused by #501YV2.
Read 6 tweets
7 Feb
.@ShabirMadh, principal investigator of the SA arm of the #astrazenecavaccine: This slide explains who participated in the SA arm of the study: Adults between 18 and 65, everyone got 2 doses, 2000 participants. To show protection we need 60% protection, Madhi says.
The Oxford/AstraZeneca study wasn't designed to determine whether the vaccine protects against severe #COVID19 disease or not. Rather, it looked at mild to moderate disease.
Those who develop severe disease are the ones who will end up in hospital or die - it's important that vaccines protect against severe disease. But our study only looked at if the vaccine protects against mild and moderate #COVID19 disease.
Read 7 tweets
7 Feb
[Thread] 1. NEW Early data (not yet peer reviewed) shows the #AstraZeneca #CovidVaccine, that SA will start to administer this month, doesn't appear to offer protection against mild/moderate disease caused by the #501YV2 variant identified in the country. bit.ly/3pZ30xx
2. Mild disease #COVID19 disease was defined as at least one symptom of COVID-19. Protection against moderate-severe COVID19, hospitalisation or death was not assessed in this study as the target population were at low risk (they were young and healthy - on average 31 years old).
3. The study results, which will be submitted as a preprint in the coming days, show two doses of the #AstraZeneca jab did have high efficacy against the original coronavirus non-#501YV2 variants in South Africa. bit.ly/3pZ30xx
Read 6 tweets

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