Latest REACT-1 study results are really important.

The headline result of prevalence now at around 0.5% masks big differences by region, employment type, HH size, and keyworker status.

(and note - in the summer, prevalence was more like 0.05-0.1%)

1/5

spiral.imperial.ac.uk/bitstream/1004…
Relative drop in prevalence between round 8 (6th-22nd Jan) and 9a (4th-13th Feb) is far greater in the S than the N and may be plateauing at around 1% in the NE.

It's helpful to know that trends in REACT generally follow trends in national PCR positivity data (in red). 2/5
Differences by deprivation group exposed yet again, plus if living in large households. Less stark differences by ethnicity (although v wide confidence intervals).

And this is AFTER adjustment for things like age, region, key work status, HH size, deprivation, ethnicity. 3/5
Health care workers still have statistically significantly higher odds of testing positive, with key workers also having higher odds (non-significant - all after adjustment). 4/5
And falls across all ages with higher rates among young adults & 5-12 y/o. Plus, as authors mention, no major signs yet of a vaccine effect on transmission.

Finally, please note - 0.5% is relatively high & the number in hospital is still about the *same* as April peak. 5/5

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More from @ADMBriggs

18 Feb
This week's PHE COVID surveillance report now out.

Most recent week covers 8th-14th Feb.

tl,dr: Things continue to improve but NHS bed/ICU situation has only *just* dipped below April peak. And some potentially worrying regional variation.

gov.uk/government/sta…
Case rates and positivity falling relatively fast. And across all ages.
Percentage of tests positive also falling, but this pillar 2 (community testing) graph has also been causing people some concern re young school children and returning to school - despite reported case rates being the lowest of all age gps.
Read 23 tweets
18 Feb
Most recent T&T data now out, covers 4th - 10th Feb

LFD use continues to rise but more slowly than last week and T&T performance remains consistent.

And as ever we don't know about who isn't tested and who struggles to isolate.

🧵

gov.uk/government/pub…
The number of people being tested each week remains high at around 3m, but this is due to increasing use of rapid lateral flow devices as PCR test use falls.
The number of LFDs used has increased five-fold since the start of Jan, and 35% in the past two weeks (although noticeable slowdown this most recent week).

By contrast, PCR test use for people with symptoms fallen week on week for the past month (PHE positivity data due later).
Read 17 tweets
14 Feb
Latest Test and Trace data now out. Covers to 3rd Feb.

Some useful separation of LFD and PCR tests, and new data on end-to-end contact tracing.

Summary in figure,🧵for the detail.

gov.uk/government/pub…
As case rates fall across the country, the number of people being tested is up 7% of last week to over 3m for the first time.

Over 5% of the population.
And as you can see from PHE data to 7th Feb - the increase is from the use of lateral flow devices (LFDs) to find cases among people without symptoms.

The number of people tested using PCR tests each week (and the proportion coming back positive - positivity) is still falling.
Read 24 tweets
11 Feb
This week's @PHE_uk COVID surveillance report is now out. Covers 1-7 Feb.

It's going in the right direction but still pockets of high case rates & hospitals are still far from getting back to anything like 'normal'.

Pls keep going, it's getting better.🧵
gov.uk/government/sta…
Case rates and positivity rates (percentage of tests coming back positive) continue to decline in all ages and everywhere.

The steep decline in 20-49yr olds is really striking.
The figures of age by region show how in some regions, the decline by age isn't so prominent.

For example, 80+ in NE and West Mids.
Read 19 tweets
4 Feb
Latest PHE weekly COVID surveillance report, covers 25th to 31st January.

Cases, admissions, deaths all falling; vaccination numbers rising.

Signs are good but ICU admission rates are still double that seen in the first wave. We're not there yet. 🧵

gov.uk/government/sta…
Case rates are falling in all ages and all regions.

The percentage of PCR tests coming back positive (positivity) is also now clearly falling in in pillar 1 (NHS/PHE labs for health care workers and those in clinical need), as well as pillar 2 (community testing).
And for those who like to squint, I really like the chart from PHE showing case rates by age and region.

For example, it shows that 0-9 yr olds track along the bottom and 20-29 yr olds along the top throughout this wave.
Read 15 tweets
28 Jan
Latest Test & Trace data - 14-20th Jan.

-Cases and tests down (except rapid lateral flow device use increasing).
-T&T turnaround times & contact tracing either similar or improving.

TL,DR: probably not great for RTs, but good for tackling COVID.

🧵

gov.uk/government/pub…
As case rates fall, so are the numbers of people getting tested - down 5% on last week.
In pillar 2 - community testing - the number of rapid LFD tests being used continues to rise, 1.3m tests used and 12.8k people tested positive (972k tests last week with 14.3k positive).

Whereas the number of P2 PCR tests was down 17%.
Read 15 tweets

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