My first #LongCOVID symptom was that I couldn't read a text message.

Most of the time when I tell people this, it's met with shock or surprise, but it's not really uncommon. Here's a piece on "Long COVID's dementia symptoms" in younger people. 1/

thetimes.co.uk/article/i-left…
"Dozens of younger adults recovering from the long-term effects of coronavirus have unexpectedly displayed dementia-like symptoms, including short-term memory loss and an inability to read or form sentences." 2/
A doctor leading a study into “long Covid” said that virtually all her patients aged between 18 and 40 had neurological problems, ranging from impaired balance and motor control to physical numbness and difficulty with language. 3/
"A cancer radiologist was forced to give up his three practices because he was unable to identify tumours in scans. A 40-year-old dialysis nurse found that she could no longer read and flooded her flat after forgetting that she had left her kitchen tap running." 4/
We at @patientled found no age difference in the cognitive dysfunction, memory loss, or impact on daily life between age groups. 5/

We also found that sensorimotor symptoms like those listed above (dizziness/vertigo, physical numbness, paresthesias) happened in 91% of #LongCovid patients.

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More from @ahandvanish

9 Feb
Tweeting the WHO's conference on #LongCOVID (called "Post COVID-19 Condition" here) as possible.

It starts off with the amazing @LongCovidSOS video from earlier this year: 1/
Dr. Pardo-Villamizar giving us a history of the (mostly neurological) symptoms from pandemics in the past. 2/
Dr. Dale Needham on post-ICU syndrome. Symptoms are similar to non-hospitalized #LongCOVID. Mentions the 6 minute walk test - would be helpful to do on non-hospitalized patients too.

Cognitive test scores look like TBIs or mild alzheimer's, no difference in severity. 3/
Read 39 tweets
6 Feb
This is an interesting #LongCOVID theory - that there is persistent brainstem dysfunction (likely in tangent with other immune issues like immune dysregulation, reactivation of other viruses, onset of autoimmune conditions).

A thread including some new & important papers: 1/
"Persistent Brainstem Dysfunction in #LongCOVID: A Hypothesis." Would be very curious to hear researchers' thoughts on this one! 2/

pubs.acs.org/doi/10.1021/ac…
Hypometabolism found in brain PET scans in #LongCOVID patients! link.springer.com/article/10.100…

Results: a decrease in brain activity in:
-olfactory bulb
-limbic regions: memory/emotion regulation
-brainstem: autonomic functions (breathing/sleeping)
-cerebellum: motor skills/balance 3/
Read 7 tweets
14 Jan
#LongCOVID fam: it took me many conversations with patient #pwme to understand that ME is a full-body systemic illness.

"Chronic fatigue syndrome" was named by a dude who later apologized for the name's triviality. ME/CFS is as severe as LC & needs to be thought of as such. 1/
His apology:

2/
Check out these symptom lists for ME from 1990 and 2001 - they look familiar...

3/
Read 5 tweets
12 Jan
This is an *excellent* piece by @math_rachel talking about the overlap of machine learning & medicine, & where it goes wrong, capturing such a wide range of issues.

This is required reading for ML folks, #MedTwitter, #LongCOVID, #NEISvoid, & everyone.

bostonreview.net/science-nature…
1/
It looks at flaws/biases in medical data (pulse oximeters are less accurate on POC, diagnoses of #EDS take 4 years for men but 16 YEARS for women), ML amplifies biases rather than counteracting them, algorithms that incorrectly cut health care with no method for recourse...

2/
...ways that this has affected #LongCOVID patients (I'd add that the focus on hospitalized patients only, or respiratory symptoms only, will be a huge problem if anyone uses ML for #LongCOVID at this stage).

3/
Read 9 tweets
4 Jan
Everyone and especially #LongCOVID folks - this is an exceptional article by @jameshamblin about the link between COVID & sleep. I didn't start getting better at all until I was able to sleep again, ~4 months in. I strongly suggest prioritizing it. 1/

theatlantic.com/health/archive…
It's not mentioned in here, but the glymphatic system of the brain is what clears waste and toxins from the central nervous system, and happens primarily during sleep. A faulty drainage system seems to be one theory behind post-viral illnesses. 2/
ncbi.nlm.nih.gov/pmc/articles/P…
Impaired glymphatic function has also been linked to Alzheimer's. Here's a paper that gives more detail on "cleaning the sleeping brain" 3/

sciencedirect.com/science/articl…
Read 4 tweets
27 Dec 20
Yay our #LongCovid paper is online!!!

medrxiv.org/content/10.110…

While we had a few thousand more fill in the survey, this paper focuses on 3,762 #longhaulers (sick >28 days) who got sick between Dec-May (to look at an average of ~6 months of data).

Some key findings:

1/
We looked at 205 symptoms over 10 organs systems (Neuropsychiatric, Pulmonary, Head Ears Eyes Nose Throat (HEENT), Gastrointestinal, Cardiovascular, Musculoskeletal, Immunologic, Dermatologic, Reproductive/Genitourinary/Endocrine).

On average, 9 in 10 of these were affected!
2/ Image
Of the 205 symptoms, we looked at 74 over time, looking at Weeks 1-4 and Months 2-7.

These graphs show the % of respondents who have reached each month who have these symptoms. Some of them go down (fever*, dry cough) while others don't. (*tho some have fever for months!) 3/ Image
Read 30 tweets

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