KIDS EPIDEMIC in Italy 🇮🇹—#B117 variant among Italy's infected schoolchildren and is helping to fuel a “robust” uptick in the curve of #COVID19–with higher transmission rates "among the youngest age group” of the population.
finance.yahoo.com/news/virus-var…
2) In recent weeks, Italy’s incidence of new cases among young people has now eclipsed incidence among the older population, a reversal of how COVID-19 afflicted residents in the first months of the pandemic.
3) Speranza announced stricter directives, contained in the first anti-pandemic decree of new Italian Premier Mario Draghi, aimed at trying to “govern this curve of contagion,” especially among school-age children.
4) There are “rather robust signs of an uptick in the curve of contagion and terrible variants,” particularly the one discovered in Britain, the minister said.
5) The president of the government Superior Institute of Health, Silvio Brusaferro, said that as of analyses of cases on Feb. 18, 54% of confirmed COVID-19 cases in Italy involved that variant. But, said Brusaferro, “if measured today surely the percentage would be higher.”
6) It all started last month with a huge outbreak of #B117 in one Italian village where 10% of all people were infected. 60% kids.
7) Denmark had a similar #B117 driven outbreak in young kids.
8) As well as a British Columbia 🇨🇦 7 school outbreak led by a few #B117 initial cases.
9) In UK where #B117 is nearly completely dominant, kids positivity has been diverging from adults.
10) It is believe there U.K. kids higher rates are due to schools reopening without enough safety precautions.
11) Israel is seeing a sharp rise in the number of children and teens getting #COVID19, where #B117 rising.

>50,000 children have been diagnosed with #COVID19 since start of Jan, many more than Israel saw in any month during the first or second waves.
m.jpost.com/health-science…
12) Instead of around 29% of new cases coming from children and teens, as in the second wave, now they are around 40% of cases, Public Health Services head Sharon Alroy-Preis said in the Knesset on Monday. The greatest spike was in children between ages of **6 - 9** (matches 🇬🇧)
13) “according to Cyrille Cohen, head of Bar-Ilan University’s immunotherapy laboratory, the numbers seem to be rising. one hypothesis is that it is tied to the British mutation #B117, which has spread rapidly across Israel.”
14) I’ve alluded to this trend in kids 0-9 before over a month ago in the #B117 data... while kids overall lower risk than adults, #B117 has yielded relatively greater increase in attack rate in kids 0-9 than increase in older age groups compared to the older common strain.
15) This 🧵 makes the clear case that school transmission of #COVID19 does occur, & increases when cases levels rise—which then further drives school transmission. It’s a deep analytical but that’s the Bottomline. Schools are not impervious to risk, especially #b117.
16) Besides #B117 being 40-60% more contagious, recently, UK says #B117 variant can be 30-70% more severe than old common strains.
17) to be clear, I’m **not** anti school reopening per se. I’m just pro **safe** school reopenings only. And the key to safe schools is improved ventilation and air disinfection — with sufficient air 5 air exchanges per hour. Here is my 🧵 on CDC’s new guidance on school air—
18) Let’s learn from Quebec 🇨🇦 that had unmasked reopening among elementary schools. Teachers and kids got infected more than general population. School cases dropped during winter break, and rose again after break was over. Let’s learn from them. Mask and ventilate schools 🙏
19) Another key detail: “The variant found in South Africa is involved in 0.4% of COVID-19 infections in Italy 🇮🇹 and mainly confined to the Italian Alpine area near the border with Austria 🇦🇹 (the part that borders Tyrol—the epicenter of #B1351 SA variant)

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More from @DrEricDing

4 Mar
📍MORE KIDS PER HOUSEHOLD ➡️ MORE RISK OF #COVID19: Danish study of 3 million adults—Increasing number of children, means much higher risk of #SARSCoV2 in adults household members. By high much?

📌2 young kids—13% ⬆️ risk

📌3+ young kids—42% ⬆️ risk
medrxiv.org/content/10.110… Image
2) What about families with young kids but not older kids (age >6)? 31% ⬆️ increased risk

What about families with older kids but no young kids? Again, 31% ⬆️ increased risk. Image
3) Okay, what if we just look at households with young kids and no older kids? How does 2 or 3+ young kids compare versus 1 young kid?

📌Adults in households with 2 young kids: 22% ⬆️ risk of #COVID19

📌Adults in households with 3+ young kids: 54% ⬆️ risk of #COVID19 Image
Read 7 tweets
4 Mar
NARROW WIN— VP Kamala Harris breaks a 50-50 tie in the Senate to proceed with the #COVID19 relief bill... 51-50. This is how narrow the fate of America’s future to stop the coronavirus pandemic comes down to.

➡️ Elections matter damnit.
2) We are here because Biden and Harris listen to scientists! Our video last fall...
3) And because the other guy dismissed science and recklessly endangered millions of lives.
Read 4 tweets
4 Mar
UNDER-DIAGNOSIS IN KIDS—New CDC-study in Mississippi found actual number of kids infected with #COVID19 was much higher than testing reported.

How much?

📌68x in May 2020

📌12x in September

The old “almost no kids risk” studies outdated. Kids transmit.
cdc.gov/mmwr/volumes/7… Image
2) “Serologic testing of residual blood specimens collected during May–September 2020, from 1,603 persons aged <18 years suggested that approximately 113,842 (16.3%) of 698,420 young persons in Mississippi might have been infected with SARS-CoV-2 by mid-September 2020.”
3) Contrast... only 8,993 confirmed and probable COVID-19 cases among young persons had been reported to the Mississippi State Department of Health by August 31.

8993 reported vs 113,842 likely pediatric cases.
Read 4 tweets
4 Mar
📍~64% MORE SEVERE—The already more contagious #B117 variant from 🇬🇧 is now found to increase risk of #COVID19 hospitalization by 64% versus other strains, says Denmark’s 🇩🇰 CDC. Denmark sequences every cases—their data is the best, & now most worrisome.🧵 papers.ssrn.com/sol3/papers.cf… Image
2) Notably, “The adjusted odds ratio was increased in all strata of age and calendar time.” (Regardless of time period & regardless of age group).
3) Conclusion: “Infection with B.1.1.7 was associated with an increased risk of hospitalisation compared with other lineages.”

➡️ “This finding may have serious public health impact in countries with spread of B.1.1.7”
Read 4 tweets
4 Mar
New—Germany's vaccine commission has approved the use of the Oxford-AstraZeneca jab for age>65. Recent studies now enough data to approve it for all ages. "new data also shows that the vaccine is even more effective when [doses 12 weeks apart]. 🧵 #COVID19
bbc.com/news/world-eur… Image
2) And indeed, the Oxford-AstraZeneca vaccine seems on par with Pfizer in mass vaccination studies. Not too shabby. economist.com/graphic-detail…
3) Here I walk people they the data on the 12 weeks being the best time gap between 1st and 2nd shot of the Oxford vaccine. That said 12 weeks has not been tested for Pfizer or Moderna ones.
Read 4 tweets
4 Mar
⚠️KIDS ages 5-12 now the *highest positive prevalence age group* for #COVID19 in England🏴󠁧󠁢󠁥󠁮󠁧󠁿 in February (not previously in Jan), despite lockdown.

➡️ Higher odds of COVID for workers in: healthcare, transport, & education, school, nursery or childcare. 🧵
spiral.imperial.ac.uk/handle/10044/1… Image
2) there is definitely something going on with the #B117 variant (where it is fully dominant in 🇬🇧) and kids. This new weird pediatric trend has been now seen in Italy 🇮🇹 Israel 🇮🇱 Denmark 🇩🇰 and many other places. Italy’s leadership sounded the alarms recently about B117 & kids.
3) We should have seen this Italian village where 60% of the cases being in primary school kids as a canary in the coal mine signal. I was very worried at the time...
Read 11 tweets

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