Thread by @omlakhani

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Karyotype must be offered to all women presenting with Premature ovarian insufficiency (POI)

There is no age cut-off per se for ordering a karyotype in women with POI. In a study, more than 30% of women with abnormal karyotype were more than 30 years of age!

Additionally, when you order a karyotype in women, it is also imperative to order FISH to look for Cryptic Y chromosome material

Women with POI with Y chromosome material are at a higher risk of gonadal neoplasia and must be offered gonadectomy to reduce such a risk

To read more on this refer to the @ESHRE guidelines on Premature ovarian insufficiency

eshre.eu/Guidelines-and…