PFIZER VACCINE & VARIANTS—Pretty good results for virus neutralization. Testing fully Pfizer-vaccinated people’s blood against spike proteins belonging to pseudo virus of variants—solid neutralization results, albeit slightly lower for #B1351 from South Africa 🇿🇦. 🧵#COVID19 
2) “All the serum samples efficiently neutralized USA-WA1/2020 and all the viruses with variant spikes. Almost all of them did so at titers higher than 1:40....” nejm.org/doi/full/10.10…
3) “Thus, as compared with neutralization of USA-WA1/2020, neutralization of B.1.1.7-spike and P.1-spike viruses was roughly equivalent, and neutralization of B.1.351-spike virus was robust but lower.”
4) that said, “Neutralizing activity against B.1.351 lineage virus was robust at a geometric mean titer that was **much higher than that obtained after one dose of [Pfizer vaccine]**”.
💡Reassuring! Even if #B1351 neutralization is lower, it’s still good—higher than 1 dose!
💡Reassuring! Even if #B1351 neutralization is lower, it’s still good—higher than 1 dose!
5) Other reassuring thing is that despite the #P1 variant having the E484K mutation as #B1351, the vaccine worked pretty solidly for P1 no problem. I’m hopeful similarly results for NIH-Moderna and J&J.
6) Side note—please remind people that none of the #COVID19 vaccines can give you Covid! A lot of people still think so—it’s incorrect!
https://twitter.com/DrEricDing/status/1369152041814212608
7) I want to point out that the J&J vaccine also performed pretty well against the #B1351 South Africa 🇿🇦 variant. All of them so far are great.
https://twitter.com/DrEricDing/status/1366619383997607941
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