Let this sink in—over **half of all intubated young adults** on ventilators now dies from #COVID19 in Brazil 🇧🇷. What’s odds last spring 2020? 1 in 3.

That is likely an effect of #P1 variant—not just ICU capacity because March 2021 wasn’t included yet. 🧵

(HT @terrence_mccoy)
2) What about overall chance of dying if intubated in Brazil 🇧🇷 hospital recently? 72.8%. Last spring—60%.
3) Brazil’s crisis is almost unimaginable. Brazil’s 4000+ deaths a day is significant - even though Us is 50% larger in population, Brazil 🇧🇷 is much much younger in age distribution compared to a much more elderly US pop. Thus it’s not just equal to 6k US—Brazil likely worse.
4) Lots of Brazilian doctors also confirm hospital cases are getting younger and younger.
5) Doctors are also saying that new #COVID19 patients are now having symptoms progressing faster and more aggressively.
6) Here is the 5 minute video in which the doctor’s interview is from. It’s a sobering video. But please watch if you can. channel4.com/news/brazils-c…
7) “Brazil is like a Fukushima, it can put the whole world at risk” — both me and @MiguelNicolelis equated Brazil to a chain reaction disaster already underway. theintercept.com/2021/04/05/ent…
8) I’ve been trying to warn for many many weeks since mid March. We needed to pay attention and send aid to Brazil. But Bolsonaro resisting. Brazil’s health ministry was also less than full speed after waiting for Bolsonaro’s 4th health minister in a year to be installed.
9) My sources in Brazil also say that Bolsonaro’s 4th health minister was installed with **explicit orders** that lockdown and major mitigation measures are prohibited. And that the minister must allow off-label use of unproven / debunked chloroquine, & ivermectin. SMH 🤦🏻‍♂️
10) A major #P1 modeling study says it is up to 2.5x faster than old strain(s). This would make it much faster than #B117 from UK.

This was done by @obscovid19br research group in Brazil.
11) Another scientific group from UK’s MRC Imperial College estimates #P1 at ~2x faster transmission anr with high reinfection potential.
12) And there is data that young adult Brazilians are dying more than before— which corroborates the ICU mortality data above from @terrence_mccoy of higher mortality among young adults on ventilators.
13) Any more data on increasing young adult mortality in Brazil?

Yes, in Parana 🇧🇷 that wasn’t hit by #P1 in January... the cafe fatality ratio (CFR) spiked in Feb once #P1 arrived by 3x in those age 20-29, and 2x in age 30-59.

This again supports ventilator mortality earlier.
14) and I agree— The catastrophic Brazilian response to covid-19 may amount to a crime against humanity

blogs.bmj.com/bmj/2021/04/05…

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More from @DrEricDing

9 Apr
“yippee!!!” ~the disgusting email Trump advisor wrote to Trump’s Asst Health Secretary after pressuring and forcing CDC leaders to muzzle the opening sentence of a report about spread of #COVID19 among younger people & blunt data unfavorable to Trump. 🧵 washingtonpost.com/health/2021/04… Image
2) “Trump appointees in the Department of Health and Human Services last year privately touted their efforts to block or alter scientists’ reports on the coronavirus to more closely align with then-President Donald Trump’s more optimistic messages about the outbreak”
3) “Even as career government scientists worked to combat the virus, a cadre of Trump appointees was attempting to blunt the scientists’ messages, edit their findings and equip the president with an alternate set of talking points.
Read 6 tweets
9 Apr
💡GOOD NEWS: Pfizer has filed with the FDA to seek emergency use authorization for adolescents ages 12-15 for its #COVID19 vaccine! Trial so far shows ~100% efficacy (18 cases in placebo, 0 in vaccine group). Pfizer applying for worldwide approvals too. 🧵
cdn.pfizer.com/pfizercom/2021… Image
2) The plans is: “Pending regulatory decision, our hope is to make this vaccine available to the 12-15-year-old age group **before the start of the 2021 school year**.”
3) “BNT162b2 was well tolerated with side effects generally consistent with those observed in participants 16 to 25 years of age. All participants in the trial will continue to be monitored for long-term protection
and safety for an additional two years after their second dose.”
Read 4 tweets
9 Apr
Being vaccinated does NOT mean that you can have a relationship w/ an underage girl & pay her to “travel” w/ you as a Congressman—then show off nude photos to colleagues while sitting on the floor of the US House of Representatives.

(Billboard @maddogpac)
2) Catch up with the drama. google.com/amp/s/www.nyti…
Read 5 tweets
9 Apr
Sharing again because important—vaccines in pregnant women are safe & maybe protect the baby. Also, antibody levels in response to vaccine>>infection. Thus, “even if you've had #COVID19, getting the vaccine will lead to a more robust antibody response”. 🙏 npr.org/sections/healt…
2) The 131 participants had been vaccinated with either the Pfizer or Moderna vaccine; 84 were pregnant, 31 were lactating, and 16 were nonpregnant 18- to 45-year-old women. The study involved patients and
3) Blood samples were collected at the time of the first and second dose of vaccine, and again after six weeks.
"The levels of antibodies, which is what we're looking for in response to vaccination, were similar between the groups," Gray says.
Read 6 tweets
8 Apr
⚠️Over 1 in 7, or 1.1 million people now suffer #LongCovid in the U.K. 🇬🇧

📌~14% who got #COVID19 in UK study suffer persistent symptoms at 12 weeks.

📌29% of all #LongCovid are under age <35

📌Top 2 occupations: healthcare workers & teachers.🧵

statista.com/chart/amp/2456… ImageImage
2) Frontline healthcare workers are among the largest group affected. Teachers are the next largest group.
3) To be clear, although 4.3 mil UK residents have confirmed #COVID19, & 1.1 mil have #LongCovid symptoms, it’s not 25% because the 1.1 mil were picked up via a survey captureing asymptomatic cases, hence 14%. That said, #LongCovid in symptomatic cases is likely higher than 14%. Image
Read 10 tweets
8 Apr
New 50% efficacy study of Brazil-predominant vaccine CoronaVac (by Sinovac) in Manaus 🇧🇷 among healthcare workers when #P1 ~75% dominant. Not a trial, but the study found a 1st dose >=14-days efficacy of 50% on symptomatic #COVID19, ~32% if +asymptomatic. medrxiv.org/content/10.110…
2) Sorry I meant ~35% if asymptomatic included with the symptomatics. But it’s not significant. Wide CIs.
3) Sinovac’s CoronaVac efficacy is all over the board. It was 50% for 2 dose efficacy in a Brazil trial, but it had 91% efficacy in early Turkey trial, and 65% in an Indonesia trial.

nature.com/articles/d4158…
Read 8 tweets

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