Airborne aerosols in a Liverpool 🇬🇧 nightclub— I’m sure if the smoke cannon was an actual virus plume, nobody would get infected right?

Crowded indoor nightclubs anyone if you’re not vaccinated? #COVID19
2) Yes, I’m aware the UK is conducting a research study in Liverpool. My concern is that we know the #sarscov2 Coronavirus has a tendency to either superspread or not due to the K dispersion factor — the transmission R is highly variable. One study enough?
bbc.com/news/newsbeat-…
3) “in real life, some people infect many others and others don’t spread the disease at all. In fact, the latter is the norm. “The consistent pattern is that the most common number is zero. Most people do not transmit.”
sciencemag.org/news/2020/05/w…
4) “That’s why in addition to R, scientists use a value called the dispersion factor (k), which describes how much a disease clusters. The lower k is, the more transmission comes from a small number of people.”
5) One study estimated that k for COVID-19 is as low as 0.1. “Probably about 10% of cases lead to 80% of the spread,” Kucharski says.

wellcomeopenresearch.org/articles/5-67
6) “That could explain some puzzling aspects of this pandemic, including why virus did not take off sooner after it emerged in China, and why some very early cases elsewhere—such as one in France in late Dec 2019, reported on 3 May—apparently failed to ignite a wider outbreak.
7) “If k is really 0.1, then most chains of infection die out by themselves and SARS-CoV-2 needs to be introduced undetected into a new country at least four times to have an even chance of establishing itself”
8) “Timing—Emerging evidence suggests COVID-19 patients are most infectious for a short period of time. Entering high-risk setting in that period may touch off a superspreading event. “2 days later, that person could behave in the same way and you wouldn’t see the same outcome.”
9) Sidenote—there is also evidence that the #B117 variant might be infectious for a longer period of time. “B.1.1.7 may even remain in human hosts nearly 2x as long as non-B.1.1.7 SARS-CoV-2, extending potential contagious period from ~ 8 days to 13 days.”
google.com/amp/s/www.forb…

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More from @DrEricDing

6 May
⚠️Don’t ignore—

"Ignoring variants today, suggesting they aren't important, leads us to ignore variants tomorrow.

Ignoring the variants of tomorrow is potentially a f***ing big mistake!"

…says Dr. @michaelmina_lab,
Harvard immunologist & epidemiologist
#COVID19 #vaccinate #P1 ImageImage
2) “variants are extremely concerning. Most data at this point shows anywhere from a 10-fold to a 30-fold reduction in nAb against the variants”
3) “When we mix these variants with elderly immune systems that will wane - we will see new cases emerge amongst fully vaccinated vulnerable in our communities this year. it will be bad in this fall and it will lead to outbreaks and deaths again.” 🔥
Read 5 tweets
6 May
Insulin was invented ~100 years ago, and its patent sold for $1.

“Do you know the reason why [insulin is] $1,000 with insurance?” ~@AOC

There is no reason for insulin to cost $21 in Canada for a 10 ml bottle, while it costs a mortgage payment in the US.
2) atrocious amount of big pharma price gouging on insulin. Absolutely atrocious. Heartbreaking atrocious. Shamefully atrocious.
3) Let this sink in:

In 2018:
J&J CEO made $30M
Pfizer CEO made $28M
Merck CEO made $18M
Eli Lilly CEO made $16M
Gilead CEO made $16M

While:

📌Americans spent $535B on Rx drugs

📌1/4 of diabetics rationed insulin to survive

📌500K Americans went bankrupt from medical bills.
Read 6 tweets
6 May
📍GET BOTH DOSES! Great variants & #COVID19 vaccine news—Pfizer/BioNTech vaccine had great efficacy of 89.5% vs #B117 🇬🇧 variant & 75% vs #B1351 🇿🇦 variant for infection—but only with 2 doses. The 1 dose efficacy was just ~29% vs #B117 & ~17% vs #B1351. 🧵
nejm.org/doi/full/10.10… Image
2) “Viral genome sequencing conducted from February 23 through March 18 indicated that 50.0% of cases of Covid-19 in Qatar were caused by B.1.351 and 44.5% were caused by B.1.1.7. Nearly all cases in which virus was sequenced after March 7 were caused by either #B1351 or #B117.”
3) To be clear—this was not a trial, but an observational case-control study. “Vaccine effectiveness was estimated with a test-negative case–control study design, a preferred design for assessing vaccine effectiveness against influenza (see the Supplementary Appendix).”
Read 7 tweets
5 May
Joe Biden waived the vaccine patents in the 4th month of his presidency. Donald Trump would not have waived the patents if he was President for another 4 years, 4 decades, or 4 centuries. Elections matter.
2) Biden’s trade ambassador has begun the process of waiving the patents. It will take time, but it’s coming.
3) Let this sink in—Trump WH actually moved to block efforts to waive the vaccine patents in October 2020!!! So damn straight Trump would have kept blocking it. washingtonpost.com/health/2021/05…
Read 4 tweets
5 May
📍VARIANT TAILORED VACCINE—Moderna announced that a variant-tailored 3rd dose of the NIH-Moderna vaccine greatly boosted antibody levels in volunteers in a new study. The updated vaccine, tailored against the #B1351 variant from 🇿🇦, worked best.🧵 #COVID19 businessinsider.com/modernas-boost… Image
2) Earlier research, done in petri dishes, suggested the B.1.351 variant was able to partially reduce the effectiveness of leading vaccines, including from Pfizer and Moderna. businessinsider.com/coronavirus-va…
3) How much did the #B1351 variant decrease neutralization from Pfizer and Moderna vaccines? A lot. 20-30x fold drop for Moderna. And 30-40x fold drop for Pfizer - akin to a completely unrelated distant bat coronavirus. While not equal to efficacy, this is a big drop. See 🧵
Read 9 tweets
5 May
Biden waives the vaccine patents. Saving humanity is more important than protecting corporate IP, which taxpayers paid for with our research dollars anyway.

In America, right matters. Saving the world matters. #COVID19 #CovidVaccine
2) Previously, the Trump WH had *blocked* patent waivers where it was first proposed in October 2020!! Let that sink in how much elections matter! washingtonpost.com/health/2021/05…
3) Been yelling about this for weeks. 50 companies stand ready to produce the vaccines. But to fully produce it, the pharma companies need to assist in technical sharing too. We can’t let pharma off the hook.
Read 4 tweets

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