INCREASE QUARANTINES? A study suggests that #B117 UK variant may remain in human hosts nearly 2x as long as non-B.1.1.7 #SARSCoV2, extending the potential contagious period from about 8 days to 13 days. This also helps explain great transmission of B117.🧵…
2) “The study was conducted in conjunction with the NBA. In Summer 2020, the NBA restarted their season after it was paused by the start of the Covid-19 pandemic. The players involved were isolated at Disneyworld resort and were administered daily Covid-19 testing.
3) “That practice expanded to the recently begun 2020-2021 season, and Harvard University took the opportunity to genome sequence the basketball players’ samples for research purposes.
5) “The Harvard researchers identified seven samples infected with B.1.1.7 among a cohort of 65 individuals infected with SARS-CoV-2.
6) ““For individuals infected with B.1.1.7, the mean duration of the proliferation phase was 5.3 days, the mean duration of the clearance phase was 8.0 days, and the mean overall duration of infection was 13.3 days.
7) These compare to a mean proliferation phase of 2.0 days, a mean clearance phase of 6.2 days, and a mean duration of infection of 8.2 days for non-B.1.1.7 virus.”
8) “Additionally, peak viral concentrations for B.1.1.7 were slightly higher than non-B.1.1.7 patients. In other words, the B.1.1.7 patients experienced extended infections with more viral particles
9) “The overall viral burden for those with B.1.1.7 was higher than their non-B.1.1.7 counterparts on average for a greater period of time.
The extended duration of B.1.1.7 is likely associated with its increased transmissibility.
10) The CDC state that B.1.1.7 transmits at 50% the rate that non-B.1.1.7 SARS-CoV-2 is capable. The virus is adjusting to our immune responses, and now, we see the B.1.1.7 capable of withstanding the human immune response over 60% longer than previous viruses.
11) Respiratory viruses typically have shorter lifespans and must jump from host to host quickly to survive and spread, but this virus sticks around for a while. Longer infections mean the virus has the opportunity to spread to more people, and positive feedback loop continues.
13) “CDC recommends that infected people remain in quarantine for 14 days but only require seven or ten days of quarantine based on the patient’s individual circumstances.”
14) “If the B.1.1.7 variant infects someone and they only quarantine for seven to ten days, they may go on to infect others thinking they are free of the virus.
15) In response to the growing concerns of variants, the Chinese government increased their required isolation period to three weeks in the past few months. This more than encompasses the 13.3-day duration the researchers observed from the B.1.1.7 variant.…
16) “If we are to control these variants before they become out of hand, we need to adjust public health policy accordingly. As the Chinese have done, we should extend quarantine requirements to three weeks. Of course, people cannot be out of work for three weeks without pay…”
17) “As @WmHaseltine has been championing for months upon months, the federal government must assist those in isolation, financially, as well as with medical supplies and shelter if necessary”

Great piece.…

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More from @DrEricDing

6 May
⚠️Don’t ignore—

"Ignoring variants today, suggesting they aren't important, leads us to ignore variants tomorrow.

Ignoring the variants of tomorrow is potentially a f***ing big mistake!"

…says Dr. @michaelmina_lab,
Harvard immunologist & epidemiologist
#COVID19 #vaccinate #P1 ImageImage
2) “variants are extremely concerning. Most data at this point shows anywhere from a 10-fold to a 30-fold reduction in nAb against the variants”
3) “When we mix these variants with elderly immune systems that will wane - we will see new cases emerge amongst fully vaccinated vulnerable in our communities this year. it will be bad in this fall and it will lead to outbreaks and deaths again.” 🔥
Read 5 tweets
6 May
Insulin was invented ~100 years ago, and its patent sold for $1.

“Do you know the reason why [insulin is] $1,000 with insurance?” ~@AOC

There is no reason for insulin to cost $21 in Canada for a 10 ml bottle, while it costs a mortgage payment in the US.
2) atrocious amount of big pharma price gouging on insulin. Absolutely atrocious. Heartbreaking atrocious. Shamefully atrocious.
3) Let this sink in:

In 2018:
J&J CEO made $30M
Pfizer CEO made $28M
Merck CEO made $18M
Eli Lilly CEO made $16M
Gilead CEO made $16M


📌Americans spent $535B on Rx drugs

📌1/4 of diabetics rationed insulin to survive

📌500K Americans went bankrupt from medical bills.
Read 6 tweets
6 May
📍GET BOTH DOSES! Great variants & #COVID19 vaccine news—Pfizer/BioNTech vaccine had great efficacy of 89.5% vs #B117 🇬🇧 variant & 75% vs #B1351 🇿🇦 variant for infection—but only with 2 doses. The 1 dose efficacy was just ~29% vs #B117 & ~17% vs #B1351. 🧵… Image
2) “Viral genome sequencing conducted from February 23 through March 18 indicated that 50.0% of cases of Covid-19 in Qatar were caused by B.1.351 and 44.5% were caused by B.1.1.7. Nearly all cases in which virus was sequenced after March 7 were caused by either #B1351 or #B117.”
3) To be clear—this was not a trial, but an observational case-control study. “Vaccine effectiveness was estimated with a test-negative case–control study design, a preferred design for assessing vaccine effectiveness against influenza (see the Supplementary Appendix).”
Read 7 tweets
5 May
Joe Biden waived the vaccine patents in the 4th month of his presidency. Donald Trump would not have waived the patents if he was President for another 4 years, 4 decades, or 4 centuries. Elections matter.
2) Biden’s trade ambassador has begun the process of waiving the patents. It will take time, but it’s coming.
3) Let this sink in—Trump WH actually moved to block efforts to waive the vaccine patents in October 2020!!! So damn straight Trump would have kept blocking it.…
Read 4 tweets
5 May
📍VARIANT TAILORED VACCINE—Moderna announced that a variant-tailored 3rd dose of the NIH-Moderna vaccine greatly boosted antibody levels in volunteers in a new study. The updated vaccine, tailored against the #B1351 variant from 🇿🇦, worked best.🧵 #COVID19… Image
2) Earlier research, done in petri dishes, suggested the B.1.351 variant was able to partially reduce the effectiveness of leading vaccines, including from Pfizer and Moderna.…
3) How much did the #B1351 variant decrease neutralization from Pfizer and Moderna vaccines? A lot. 20-30x fold drop for Moderna. And 30-40x fold drop for Pfizer - akin to a completely unrelated distant bat coronavirus. While not equal to efficacy, this is a big drop. See 🧵
Read 9 tweets
5 May
Biden waives the vaccine patents. Saving humanity is more important than protecting corporate IP, which taxpayers paid for with our research dollars anyway.

In America, right matters. Saving the world matters. #COVID19 #CovidVaccine
2) Previously, the Trump WH had *blocked* patent waivers where it was first proposed in October 2020!! Let that sink in how much elections matter!…
3) Been yelling about this for weeks. 50 companies stand ready to produce the vaccines. But to fully produce it, the pharma companies need to assist in technical sharing too. We can’t let pharma off the hook.
Read 4 tweets

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