“I know that this is not a politically easy thing to do. So I very much appreciate the leadership of the United States", says @DrTedros at @WHO presser on #covid19 about US support for #TRIPSwaiver “We urge other countries to follow their example.”
@DrTedros @WHO "We are in an unprecedented crisis that requires unprecedented action”, says @drtedros.
“The World Trade Organization provisions for IP waivers were designed precisely for a situation like this.
If we don't use them now, then when?"
@DrTedros @WHO This is important news:
"This afternoon, WHO gave emergency use listing to Sinopharm Beijing's #COVID19 vaccine, making it the sixth vaccine to receive WHO validation for safety, efficacy and quality."
@DrTedros @WHO (Sinopharm’s vaccine is an inactivated virus vaccine. @nytimes has a nice explainer here:
nytimes.com/interactive/20…)
@DrTedros @WHO @nytimes “Fundamentally what we want to do is reverse the usual logic” says @MazzucatoM, chair of @WHO Council on the Economics of Health for All.
Not “invest in health, because it's good for the economy”, but focus on health for all, then “understand how to restructure economy"
@DrTedros @WHO @nytimes @MazzucatoM Q: is there any safe way for Olympics to happen?
"we will leave it to the authorities in Japan who are highly competent to decide what level of attendance could occur in the Olympics”, says @DrMikeRyan. Travel to Olympics from abroad is not on the table, he says.
@DrTedros @WHO @nytimes @MazzucatoM @DrMikeRyan “The issue will be the extent to which social mixing and socializing is allowed around the Olympic venues themselves”, says @DrMikeRyan. “Decisions around that level of mixing will be made by the Japanese authorities in due course”, based on epidemiological situation.
@DrTedros @WHO @nytimes @MazzucatoM @DrMikeRyan “The information we have for people over 60 is still very scarce”, says SAGE chair, Alejandro Cravioto on efficacy of Sinopharm vaccine. Still recommended for all people aged 18+. "There is no reason to think that the vaccine would behave differently in this older age group."
@DrTedros @WHO @nytimes @MazzucatoM @DrMikeRyan Q about vaccinating children.
Cravioto: “For the time being, we don't think that there is the vaccine or the actual need to start thinking of this age group as a priority group within the framework that SAGE has designed to see who should be vaccinated and in which sequence."
@DrTedros @WHO @nytimes @MazzucatoM @DrMikeRyan “We are aware that Canada did authorize the use of the Pfizer vaccine for 12-15 year olds on Wednesday, the first country to provide such an authorization, and we do expect additional authorizations to come through for younger age groups, below the age of 16”, says @Kate_L_OBrien
@DrTedros @WHO @nytimes @MazzucatoM @DrMikeRyan @Kate_L_OBrien “We would really like to re-emphasize that the priority really needs to be getting vaccine to all countries in the world for the highest priority groups before we start advancing to groups that have much lower risk of disease”, says @Kate_L_OBrien
@DrTedros @WHO @nytimes @MazzucatoM @DrMikeRyan @Kate_L_OBrien Q about B.1.617 (variant identified in India)
This variant "is one that we are looking at very, very carefully looking at data that is coming directly from our colleagues in India who are studying this virus variant, as well as studies" in other countries”, says @mvankerkhove
@DrTedros @WHO @nytimes @MazzucatoM @DrMikeRyan @Kate_L_OBrien @mvankerkhove "My concern right now is that this virus has huge kinetic energy”, says @DrMikeRyan, driven by human behaviour, variants and other factors.
“We're pushing three different accelerators at the same time, and we expect the virus to slow down.”
@DrTedros @WHO @nytimes @MazzucatoM @DrMikeRyan @Kate_L_OBrien @mvankerkhove “Some countries are at such a rate of infection that their health systems are back under severe pressure”, says @DrMikeRyan. “We've seen the tragedy in India. We need to avoid that same tragedy occurring in other countries and some other countries are heading in that direction."
@DrTedros @WHO @nytimes @MazzucatoM @DrMikeRyan @Kate_L_OBrien @mvankerkhove "I have exactly the same hope that we will eventually get to vaccination coverage rates that will protect everybody, but we're not there yet”, says @DrMikeRyan. "We are simply not there yet."
@DrTedros @WHO @nytimes @MazzucatoM @DrMikeRyan @Kate_L_OBrien @mvankerkhove Variants may be contributing to spike in infections, says @DrMikeRyan, but it is driven by crowding and mixing of people, poor ventilation, no masks. etc.
"I know how hard that is in the context of some countries, but that is the brutal reality."
@DrTedros @WHO @nytimes @MazzucatoM @DrMikeRyan @Kate_L_OBrien @mvankerkhove “Some countries really need to take a look in the mirror in terms of what they are doing to drive down infection rates”, says @DrMikeRyan. "Otherwise health care systems in many countries will face real issues in the coming weeks and months."
@DrTedros @WHO @nytimes @MazzucatoM @DrMikeRyan @Kate_L_OBrien @mvankerkhove "I think at this point, many of us may have expected we'd be coming out of this pandemic and we'd be thinking about the future.
We're not.
We're still in the heart of this thing”, says @DrMikeRyan.

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More from @kakape

7 May
UK’s Joint Committee on Vaccination and Immunisation is now advising healthy adults younger than 40 “to receive an alternative to the Oxford/AstraZeneca vaccine – where available and only if this does not cause substantial delays in being vaccinated”.

gov.uk/government/new…
This is based on the fact that “the chances of a younger person becoming seriously ill with #COVID19 get smaller as infection rates increasingly come under control in the UK”.
@GretchenVogel1 and explored these trade-offs in risk and benefit here:

sciencemag.org/news/2021/05/w…
@GretchenVogel1 UK's regulator, the MHRA:
"The balance of benefits and risks is very favourable for older people but is more finely balanced for younger people and we advise that this evolving evidence should be taken into account when considering the use of the vaccine”
gov.uk/government/new…
Read 4 tweets
4 May
So where are we on the rare clotting disorder linked to AZ and J&J shots? What do we know? How do risks and benefits compare? What does it mean long-term and around the world?
@GretchenVogel1 and I tried to answer some questions, thread to come in a bit.

sciencemag.org/news/2021/05/w…
First off:
This is complex and I‘m tired of people pretending it‘s all obvious.

So a few general points about the decisions that have to be made here:
They are
- local, but with global implications
- based on imperfect data in an evolving pandemic
- about individual decisions as well as population-level effects (and these two things can point in opposite directions)
Read 20 tweets
23 Apr
In the US the Advisory Committee on Immunization Practices (ACIP) is meeting at the moment to discuss data on the rare clotting disorders seen after immunization with J&J’s #covid19 vaccine and to make recommendations on future use of the vaccine.
I’ll tweet along a bit.
Outcomes from the rare clotting disorders are likely to improve from "recognition among physicians also recognition in the public that if you develop a severe headache, severe abdominal pain that you really need to see your doctor", says @mstreif1.
@mstreif1 As of 21 April, 15 confirmed cases of the rare clotting disorder (here called TTS, Thrombosis with Thrombocytopenia Syndrome) after about 8 million vaccinations with J&J’s #covid19 vaccine, says @CDCgov's Tom Shimabukuro
Read 50 tweets
23 Apr
So @EMA_News is finally doing some decent communication/visualization of risks/benefits of vaccination with AstraZeneca’s #covid19 shot.

Quick thread with their graphs:
@EMA_News They looked at hospitalisations, ICU admissions and deaths from #covid19 separately.

Also 3 scenarios for monthly infection rates:
low (55 per 100,000 people)
medium (401 per 100,000 people) high (886 per 100,000 people)

Here are the graphs for hospitalisations:
@EMA_News Here are the three graphs for ICU admissions:
Read 8 tweets
20 Apr
“We have now heard of 8 cases of these very rare side effects as part of the rollout in the US, where the vaccine has been given to over 7 million vaccinees”, says EMA head Emer Cooke at press briefing on the safety review of J&J's #covid19 vaccine.
“This is a very rare effect but it also makes it very important for doctors and patients to be aware of the signs so that they can spot any concerns and seek specialist help as soon as possible”, says Cooke. "Early intervention by specialists can change the outcome."
"The scientific assessment that PRAC has concluded on today will allow vaccination programs in member states to take decisions on how to roll out this vaccine based on their national situation” (infections, hospitalizations, ICU admissions, vaccine availability), says Cooke.
Read 18 tweets
16 Apr
Getting a bit annoyed at everyone using numbers from yesterday’s Oxford pre-print to compare how often CVST occurs after mRNA vaccines and AstraZeneca vaccine.
We cannot directly compare these numbers because they came about in completely different ways.
The authors say so themselves IN the preprint:
"we cannot directly compare the risks of CVT associated with ChAdOx1 nCoV-19 with any of the other vaccines, or with COVID-19, since we are using data collected by the EMA monitoring system, not from the electronic health records..."
And yes, @UniofOxford press release does exactly that anyway:
"Compared to the AZ-Oxford vaccine, the risk of a CVT from COVID-19 is about 8 times greater."

This is one reason (of many) why we need science journalists and not just press releases.

ox.ac.uk/news/2021-04-1…
Read 5 tweets

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