The most comprehensive review of how the world responded to #covid19 and how to prevent the next pandemic was published today.
It will likely be the basis of discussions in coming months and years and so I read it for you.

Story here, thread to come:
sciencemag.org/news/2021/05/t…
Who wrote the report?
This is the Independent Panel for Pandemic Preparedness and Response (IPPPR), established last year in response to a resolution of the World Health Assembly.
It consists of 13 members led by @HelenClarkNZ and @MaEllenSirleaf.
@HelenClarkNZ @MaEllenSirleaf (To be completely transparent:
I was actually interviewed by this panel in February but only about the communication aspects of the pandemic. I have no other involvement with this report or the panel.)
@HelenClarkNZ @MaEllenSirleaf There are a ton of important points and quotes in the report, but this may be the key one:

“Pandemics pose potential existential threats to humanity and must be elevated to the highest level.”
@HelenClarkNZ @MaEllenSirleaf Let’s look at the panel's analysis of what went wrong first:
@HelenClarkNZ @MaEllenSirleaf 1. We were warned. Again and again and again. We didn’t listen.
“Despite the consistent messages that significant change was needed to ensure global protection against pandemic threats, the majority of recommendations were never implemented."
@HelenClarkNZ @MaEllenSirleaf 2. Countries did not give this the needed money and attention.
“Too many national governments lacked solid preparedness plans, core public health capacities and organised multi sectoral coordination with clear commitment from the highest national leadership."
@HelenClarkNZ @MaEllenSirleaf 3. WHO was late in declaring the outbreak a PHEIC.
"The Panel’s view is that the outbreak in Wuhan is likely to have met the criteria to be declared a PHEIC by the time of the first meeting of the Emergency Committee on 22 January 2020."
@HelenClarkNZ @MaEllenSirleaf 4. WHO could have warned of h2h transmission earlier.
"While WHO advised
of the possibility of human-to-human transmission ... Panel’s view is that it could also have told countries that they should take the precaution of assuming that human-to-human transmission was occurring."
@HelenClarkNZ @MaEllenSirleaf 5. The International Health Regulations (IHR) which govern what WHO can do slowed down the response.
"the legally binding IHR (2005) are a conservative instrument as currently constructed and serve to constrain rather than facilitate rapid action"
@HelenClarkNZ @MaEllenSirleaf 6. Even when PHEIC was declared, countries did not respond.
“in the absence of certainty about how serious the consequences of this new pathogen would be, “wait and see” seemed a less costly and less consequential choice than concerted public health action”.
@HelenClarkNZ @MaEllenSirleaf I felt this one in my bones:
“It is glaringly obvious to the Panel that February 2020 was a lost month, when steps could and should have been taken to curtail the epidemic and forestall the pandemic."
@HelenClarkNZ @MaEllenSirleaf 7. When countries responded some did not do it based on evidence.
"Countries that devalued science failed to build trust in their response and pursued inconsistent strategies that left them lagging behind the epidemic and with high infection and death rates."
@HelenClarkNZ @MaEllenSirleaf 8. Health systems were underfunded and ill-prepared.
"Health systems and health workers were not prepared for a prolonged crisis. ...The health systems which had been under-resourced and fragmented over a long period prior to the pandemic were the least resilient."
@HelenClarkNZ @MaEllenSirleaf 9. Existing inequities made things much worse.
“The Panel notes that COVID-19 has been a pandemic of inequalities and inequities … Inequality has been the determining factor explaining why the COVID-19 pandemic has had such differential impacts on peoples’ lives and livelihoods"
@HelenClarkNZ @MaEllenSirleaf The upshot of all this?

"For the Panel it is clear that the combination of poor strategic choices, unwillingness to tackle inequalities, and an uncoordinated system created a toxic cocktail which allowed the pandemic to turn into a catastrophic human crisis."
@HelenClarkNZ @MaEllenSirleaf Before I tackle the panel’s recommendations (maybe in a separate thread), let me add some thoughts from myself and some experts I spoke to about these points that the panel identified as contributing to the pandemic:
@HelenClarkNZ @MaEllenSirleaf Most people I spoke to agree that a PHEIC should have been issued a week earlier (several told me so at the time).
But they also agree it’s beside the point. As @angie_rasmussen told me: “In my opinion that wouldn't have changed anything about the pandemic.”
@HelenClarkNZ @MaEllenSirleaf @angie_rasmussen What this does highlight is the structural problem of how WHO has to operate under the International Health Regulations.
As the panel notes, the IHR place “greater emphasis on action that should not bet taken, rather than on action that should"
@HelenClarkNZ @MaEllenSirleaf @angie_rasmussen The panel fails to call out bad actors, like China for its early handling of the outbreak, @LawrenceGostin told me:
“The independent panel had the opportunity to give WHO political cover to name names, to identify fault, honestly, where it occurs. And they didn't do that.”
@HelenClarkNZ @MaEllenSirleaf @angie_rasmussen @LawrenceGostin And while you can talk a lot about international organizations, as @JeremyFarrar told me, the decisions ultimately rest with national governments: “Look at Europe: the tightest region of countries linked together in the world and they effectively all acted individually."
@HelenClarkNZ @MaEllenSirleaf @angie_rasmussen @LawrenceGostin @JeremyFarrar I’ll stop here and write about the core of the report, its recommendations in a separate thread later.
Or you just read my story: sciencemag.org/news/2021/05/t…

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More from @kakape

10 May
"Globally, we are now seeing a plateauing in the number of #COVID19 cases and deaths, with declines in most regions”, says @DrTedros at @WHO presser. "But it’s an unacceptably high plateau, with more than 5.4 million reported #covid19 cases and almost 90.000 deaths last week."
@DrTedros @WHO “We've been here before”, says @drtedros. “Over the past year, many countries have experienced a declining trend in cases and deaths, relaxing public health and social measures too quickly, and individuals have laid down their guard, only for those hard won gains to be lost."
@DrTedros @WHO "We are still in a perilous situation”, says @DrTedros.
"The spread of variants, increased social mixing, the relaxation of public health and social measures and inequitable vaccination, are all driving transmission."
Read 5 tweets
10 May
Norway’s expert committee „does not recommend the inclusion of vaccines based on adenoviral vectors in the national vaccination program“

Should not come as a surprise to those who have followed @GretchenVogel1 and my reporting

H/t @Sciencenorwayno
regjeringen.no/contentassets/…
@GretchenVogel1 @Sciencenorwayno I have made the point again and again that his is about context.
In this case on top of low infection rates (see page 9):
- mRNA vaccines are becoming available faster in Norway
- 2nd dose of mRNA now to be given after 12 weeks, so more people will get first dose faster.
@GretchenVogel1 @Sciencenorwayno If the context changes, decision may too:
Recommendation is "based on the level of knowledge we have at present… Changes in infection rates, new virus mutants, unforeseen problems with vaccine deliveries and new information about side effects could lead to other conclusions"
Read 4 tweets
7 May
“I know that this is not a politically easy thing to do. So I very much appreciate the leadership of the United States", says @DrTedros at @WHO presser on #covid19 about US support for #TRIPSwaiver “We urge other countries to follow their example.”
@DrTedros @WHO "We are in an unprecedented crisis that requires unprecedented action”, says @drtedros.
“The World Trade Organization provisions for IP waivers were designed precisely for a situation like this.
If we don't use them now, then when?"
@DrTedros @WHO This is important news:
"This afternoon, WHO gave emergency use listing to Sinopharm Beijing's #COVID19 vaccine, making it the sixth vaccine to receive WHO validation for safety, efficacy and quality."
Read 18 tweets
7 May
UK’s Joint Committee on Vaccination and Immunisation is now advising healthy adults younger than 40 “to receive an alternative to the Oxford/AstraZeneca vaccine – where available and only if this does not cause substantial delays in being vaccinated”.

gov.uk/government/new…
This is based on the fact that “the chances of a younger person becoming seriously ill with #COVID19 get smaller as infection rates increasingly come under control in the UK”.
@GretchenVogel1 and explored these trade-offs in risk and benefit here:

sciencemag.org/news/2021/05/w…
@GretchenVogel1 UK's regulator, the MHRA:
"The balance of benefits and risks is very favourable for older people but is more finely balanced for younger people and we advise that this evolving evidence should be taken into account when considering the use of the vaccine”
gov.uk/government/new…
Read 4 tweets
4 May
So where are we on the rare clotting disorder linked to AZ and J&J shots? What do we know? How do risks and benefits compare? What does it mean long-term and around the world?
@GretchenVogel1 and I tried to answer some questions, thread to come in a bit.

sciencemag.org/news/2021/05/w…
First off:
This is complex and I‘m tired of people pretending it‘s all obvious.

So a few general points about the decisions that have to be made here:
They are
- local, but with global implications
- based on imperfect data in an evolving pandemic
- about individual decisions as well as population-level effects (and these two things can point in opposite directions)
Read 20 tweets
23 Apr
In the US the Advisory Committee on Immunization Practices (ACIP) is meeting at the moment to discuss data on the rare clotting disorders seen after immunization with J&J’s #covid19 vaccine and to make recommendations on future use of the vaccine.
I’ll tweet along a bit.
Outcomes from the rare clotting disorders are likely to improve from "recognition among physicians also recognition in the public that if you develop a severe headache, severe abdominal pain that you really need to see your doctor", says @mstreif1.
@mstreif1 As of 21 April, 15 confirmed cases of the rare clotting disorder (here called TTS, Thrombosis with Thrombocytopenia Syndrome) after about 8 million vaccinations with J&J’s #covid19 vaccine, says @CDCgov's Tom Shimabukuro
Read 50 tweets

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