Antimicrobials in COVID-19 Patients in ICU is one of our sessions at the #C19marathon this Saturday - let's have a look at some of the current literature ahead of the session.
Due to the high amounts of multi-drug resistant organisms, superimposed infections are problematic in C19 patients - via immune dysregulation and mechanical ventilation. karger.com/Article/FullTe…
There are many studies that have referenced multiple organisms with varying mortalities and abx-use profiles: karger.com/Article/FullTe…
NICE (May, 2020) treatment guidance for severe hospital-acquired pneumonia in COVID-19 patients includes broad-spectrum antibiotics such as piperacillin-tazobactam, ceftazidime and levofloxacin. Vancomycin, teicoplanin and linezolid if MRSA is suspected. karger.com/Article/FullTe…
Usual difficulties with CRP/PCT as biomarkers in infection - but meta-analysis suggests risk of severe COVID-19 infx to be 5x more in patients with raised PCT - these patients with raised PCT on admission had a greater risk of secondary bacterial infection karger.com/Article/FullTe…
And indeed, we have seen unrestricted broad-spectrum abx use across the board. jidc.org/index.php/jour…
In 197 C19 patients in ICU, 44.7% = at least 1 bacterial infx (pneumonia (39.1%) and bloodstream infx (15,7%).) Unusual findings include frequent suspicion of bacterial translocations originating from GI tract as well as bacterial persistence in the lungs. journals.plos.org/plosone/articl…
Unsurprisingly, there is a loud call for detailed antimicrobial stewardship and clinical algorithms to rationalise prescribing: link.springer.com/article/10.100…
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Today, we'll be using the hashtag: #livesc19 for all content.
#livesc19 We'll kick off by looking at what went well and what we can do better together, accompanied by a global update on #COVID19. A focus on the science used to fight the pandemic and the successes/difficulties we had throughout the world. @DrMCecconi@msh_manu@strachanjamie
@FT graph showcasing the cumulative confirmed cases in various countries/areas. Raw numbers log, then per million linear. The steepness of the increase in NI is obviously a worrying trend.
Thank you @NSWOC who have produced a great powerpoint, summarised below, on Prevention and Management of Skin Damage Related to Personal Protective Equipment (PPE) 👇👇nswoc.ca/ppe/#FOAMed#FOAMcc#COVID19#PPE
The data does not include Scottish ICUs - but does for Eng, Wales and NI. To date (yday) there have been 6664 ICU admissions due to COVID19. The largest cohort being in London. There is also cumulative data of numbers by date. #covid19#covid19foam#foamed#FOAMcc