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Vinod Scaria

6 Jun, 9 tweets, 4 min read

Interesting preprint on the antibody response after ChAdOx1-nCOV (Covishield) and BBV-152 (Covaxin) among Health Care Workers. (N=552 Covishield =456; Covaxin=96)
Both vaccines elicited👍immune response after 2nd dose. Seropositivity Covishield >Covaxin
medrxiv.org/content/10.110…

A number of factors include Age, Sex. Comorbidity including T2DM and Hypertension influence the antibody titres (Day 21-36 after 2nd dose)

More reasons why we should be eagerly looking forward to the Phase 3 data for Covaxin

Another preprint now online on Immunogenicity of the ChAdOx1 nCoV-19 and the BBV152 Vaccines in Patients with Autoimmune Rheumatic Diseases.
papers.ssrn.com/sol3/papers.cf…

The data also has healthy controls in comparison where the Ab titres have been examined. While small numbers cannot really ascertain the differences, the Median & IQR values show the same trend in Covaxin vs Covishield

And many other issues with the preprint has been summarised journosdiary.com/2021/06/06/cov…

Meanwhile in a parallel universe

@shananalla

A new preprint comparing the neutralization against B.1.351 and B.1.617.2 compared to B.1 with sera of COVID-19 recovered cases and vaccinees of BBV152
biorxiv.org/content/10.110…

Thanks @shananalla for pointing this out.

One cannot but agree to the very fact as stated on conflicts of interest section.

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More from @vinodscaria

Vinod Scaria

@vinodscaria

20 Apr

B.1.618 - a new lineage of SARS-CoV-2 predominnatly found in India and characterized by a distinct set of genetic variants including E484K , a major immune escape variant.

Initial sequences in the B.1.618 lineage were found in West Bengal, India.

Members of this lineage is also found in other parts of the world, cov-lineages.org/lineages/linea… but do not have the full complement of variants as found in India

This lineage is characterized by a 6 nt deletion (H146del &Y145del) , apart from E484K and D614G in spike protein
Other variants are in the ORF1ab, ORF3a, ORF7a, ORF7b and N genes

Read 9 tweets

Vinod Scaria

@vinodscaria

10 Apr

B.1.617 is the name
Find more information on the lineage at cov-lineages.org/lineages/linea…

This lineage is defined by 15 genetic variants including 6 Spike protein variants.
Two variants of these 6 (E484Q and L452R) are involved in immune escape as well as increased infectivity. More about these variants and immune escape can be found at ESC clingen.igib.res.in/esc

This lineage is also now found in a number of countries including UK, USA, Australia, Singapore and Germany

Read 9 tweets

Vinod Scaria

@vinodscaria

23 Sep 20

First report of #COVID19 #reinfection from #India - two #asymptomatic health workers identified on routine #surveillance
academic.oup.com/cid/advance-ar…

#CSIRfightsCOVID19

#Genome sequencing of the #SARSCoV2 isolates from both the episodes suggest distinctly different virus , confirming reinfection.

Since the individuals were #asymptomatic during both episodes, and identified on regular #surveillance suggest asymptomatic #reinfections could be an under-reported entity. 2/2

Read 5 tweets

Vinod Scaria

@vinodscaria

24 Aug 20

Facebook live in #Malayalam at facebook.com/INDIA.CSIR on 28th August 2020 from 3.00PM to 4.00PM

Facebook live in #Malayalam at facebook.com/INDIA.CSIR on 28th August 2020 from 5.00PM to 6.30PM (please note the change in time)

Read 4 tweets

Vinod Scaria

@vinodscaria

12 Aug 20

@IGIBSocial

High throughput approach to detection and genetic epidemiology of SARS-CoV-2 using Next Generation Sequencing #CSIRfightsCOVID19 @IGIBSocial @CSIR_IND

thehindu.com/sci-tech/healt…

High throughput approaches for detection and genetic epidemiology of SARS-CoV-2 holds key as we open up economic hubs & cities. #COVIDseq provides the way forward.

@IGIBSocial

@IGIBSocial in #India is one of the initial centres to evaluate this approach globally and suggesting high sensitivity for detection, along with the opportunity to do genetic epidemiology to understand dynamics.

Read 5 tweets

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